[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642807":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":53,"collaborators":25,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":59,"sex":65,"minAge":66,"maxAge":25,"enrollmentInfo":67,"targetDuration":25,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":85,"whyStopped":25,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"China National Center for Cardiovascular Diseases","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Virtual Stenting-Guided PCI Optimization","EXPERIMENTAL","Participants randomized to the experimental group will undergo coronary imaging-physiology fusion-based virtual stenting analysis before PCI. Predicted post-PCI physiological outcomes will be used to optimize interventional strategies, including lesion coverage, stent length, stent position, and procedural planning before stent implantation.",[13],"Procedure: Virtual Stenting-Guided PCI Optimization",{"label":15,"type":16,"description":17,"interventionNames":18},"Angiography-Guided PCI","ACTIVE_COMPARATOR","Participants randomized to the control group will undergo PCI according to standard angiographic guidance and operator judgment without virtual stenting-guided physiological optimization.",[19],"Procedure: Standard Angiography-Guided PCI",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Preprocedural physiological optimization of PCI using coronary imaging-physiology fusion-based virtual stenting technology based on angiography-derived Quantitative Flow Ratio (QFR) assessment to guide stent implantation strategy.",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Standard Angiography-Guided PCI","Conventional percutaneous coronary intervention performed according to angiographic findings and routine clinical practice without use of virtual stenting-guided physiological optimization.",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Ying Song, MD","CONTACT","+86-10-68314466","songying@fuwai.com",[37],{"facility":38,"status":25,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Fuwai Hospital, CAMS & PUMC","Beijing","Beijing Municipality","100037","China","CN",{"type":45,"coordinates":46},"Point",[47,48],116.39723,39.9075,{"lat":48,"lon":47},[51],{"name":32,"role":33,"phone":52,"phoneExt":25,"email":35},"8688396666",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Ying Song","Principal Investigator","100642807","qfr-guided-virtual-stenting-for-preprocedural-physiological-optimization-of-percutaneous-coronary-intervention-a-randomized-controlled-trial-100642807",false,"NCT07635407","QFR-Guided Virtual Stenting for Preprocedural Physiological Optimization of Percutaneous Coronary Intervention: A Randomized Controlled Trial","A Multicenter, Prospective, Randomized Controlled Trial of Preprocedural Physiological Optimization of Percutaneous Coronary Intervention Using Coronary Imaging-Physiology Fusion-Based Virtual Stenting Technology","FAVOR-Virtual","Inclusion Criteria:\n\n* Age ≥18 years.\n* Diagnosis of coronary artery disease requiring percutaneous coronary intervention (PCI) according to current clinical practice.\n* Presence of at least one target coronary lesion considered suitable for PCI and evaluable by angiography-derived Quantitative Flow Ratio (QFR).\n* Ability to undergo coronary angiography and PCI. Provision of written informed consent before study participation.\n\nExclusion Criteria:\n\n* Contraindications to PCI or inability to undergo coronary intervention. Severe renal dysfunction or other conditions making angiographic procedures unsuitable.\n* High bleeding risk judged by investigators.\n* Inability to complete follow-up or comply with study procedures.\n* Life expectancy less than 1 year due to non-cardiovascular comorbidities.\n* Participation in another interventional clinical trial that may interfere with study outcomes.\n* Coronary anatomy unsuitable for QFR-based virtual stenting analysis.\n* Any condition judged by investigators to make study participation inappropriate.","ALL","18 Years",{"count":68,"type":69},1472,"ESTIMATED","INTERVENTIONAL",[72],"NA","Coronary angiography-guided percutaneous coronary intervention (PCI) remains the standard treatment strategy for patients with coronary artery disease; however, suboptimal post-PCI physiological outcomes remain common and are associated with adverse cardiovascular prognosis. Quantitative Flow Ratio (QFR)-based virtual stenting technology enables simulation of post-intervention coronary physiology before PCI and may facilitate individualized optimization of stent implantation strategies.\n\nThis multicenter, prospective, randomized controlled trial aims to evaluate whether preprocedural physiological optimization of PCI using coronary imaging-physiology fusion-based virtual stenting technology improves clinical outcomes compared with conventional angiography-guided PCI. Eligible patients undergoing PCI for coronary artery disease will be randomized in a 1:1 ratio to either virtual stenting-guided PCI optimization or standard angiography-guided PCI.\n\nThe primary endpoint is major adverse cardiovascular events (MACE), defined as a composite of all-cause death, nonfatal myocardial infarction, and ischemia-driven repeat revascularization within 1 year after PCI. Secondary endpoints include post-PCI physiological optimization, cardiovascular death or nonfatal myocardial infarction, repeat revascularization, quality of life, procedural safety, and health economic outcomes.",[75,76,77],"Coronary Artery Disease","Coronary Stenosis","Ischemic Heart Disease",[79,80,81,82,75,83,84],"Percutaneous Coronary Intervention","Quantitative Flow Ratio","Virtual Stenting","Coronary Physiology","Physiological Optimization","Functional Revascularization","NOT_YET_RECRUITING","2026-06-07",{"date":88,"type":89},"2026-06-09","ACTUAL",{"date":91,"type":69},"2026-07-01",{"date":93,"type":69},"2028-12-31",{"name":5,"class":6},1]