[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624762":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":22,"responsibleParty":35,"collaborators":10,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":40,"sex":46,"minAge":47,"maxAge":10,"enrollmentInfo":48,"targetDuration":51,"studyType":52,"phases":10,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Ankara University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Procedural Sedation with CONOX Monitoring",null,"Adult patients undergoing elective urological procedures under monitored anesthesia care with continuous CONOX monitoring. All patients receive standard procedural sedation with propofol target-controlled infusion (Eleveld model) and fentanyl (1 mcg\u002Fkg), maintaining spontaneous ventilation without neuromuscular blockade. The CONOX monitor continuously records qCON, qNOX, and EMG indices throughout the procedure.",[13],{"name":14,"affiliation":5,"role":15},"Çiğdem YILDIRIM GÜÇLÜ, MD","PRINCIPAL_INVESTIGATOR",[17],{"name":18,"role":19,"phone":20,"phoneExt":10,"email":21},"Cahit Sefer Uçar, MD","CONTACT","+905532774107","cs.ucar@hotmail.com",[23],{"facility":5,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":10,"cosmosGeoPoint":29,"geoPoint":34,"contacts":10},"RECRUITING","Ankara","Altındağ","06230","Turkey (Türkiye)",{"type":30,"coordinates":31},"Point",[32,33],32.85427,39.91987,{"lat":33,"lon":32},{"type":15,"investigatorFullName":36,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"CIGDEM YILDIRIM GUCLU","Professor of Anesthesiology and Reanimation","100624762","qnox-response-to-nociceptive-motor-events-during-procedural-sedation-100624762",false,"NCT07413848","qNOX Response to Nociceptive Motor Events During Procedural Sedation","Performance of the CONOX Monitor Without Neuromuscular Blockade: qCON and qNOX Responses to Nociceptive Motor Events During Procedural Sedation","MO-NOX","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective diagnostic or therapeutic urological procedures (cystoscopy, ureteroscopy, prostate biopsy, intradetrusor botulinum toxin injection) under monitored anesthesia care\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Known central neurological disease (epilepsy, Alzheimer's disease, Parkinson's disease, stroke) or history of brain surgery\n* Body Mass Index (BMI) ≥35 kg\u002Fm²\n* Known allergy to anesthetic agents used in the study (propofol, fentanyl, lidocaine)","ALL","18 Years",{"count":49,"type":50},120,"ESTIMATED","1 Day","OBSERVATIONAL","The goal of this observational study is to evaluate whether the CONOX monitor can detect pain during sedation in patients undergoing urological procedures. The main questions it aims to answer are:\n\nDoes the qNOX index respond to pain-related motor responses during urological procedural sedation? Does the qNOX index show greater responsiveness to painful episodes compared to blood pressure and heart rate? Participants undergoing urological procedures (such as cystoscopy) under sedation as part of their regular medical care will have continuous brain activity monitoring with the CONOX device. All monitoring displays (CONOX monitor, vital signs monitor, and target-controlled infusion pump) will be video-recorded throughout the procedure to capture synchronized data including qCON, qNOX, EMG, heart rate, blood pressure, oxygen saturation, and drug concentrations. Researchers will analyze the relationship between these indices and spontaneous movements triggered by painful stimulation to evaluate the monitor's performance compared to traditional vital signs.",[55,56,57],"Monitoring Noxious Events Using EEG-Derived Pain Indices","Procedural Sedation and Analgesia","Monitored Anesthesia Care",[59,60,61,62,63,64,65],"EEG Monitoring","CONOX Monitor","qNOX Index","qCON Index","Target Controlled Infusion","Procedural Sedation","Propofol","2026-02-15",{"date":68,"type":69},"2026-02-18","ACTUAL",{"date":71,"type":69},"2026-01-14",{"date":73,"type":50},"2026-05-30",{"name":5,"class":6},1]