[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589378":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":69,"collaborators":26,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":73,"sex":79,"minAge":80,"maxAge":26,"enrollmentInfo":81,"targetDuration":26,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":95,"whyStopped":26,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"University of Tennessee Graduate School of Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","PLACEBO_COMPARATOR","The control (placebo comparator) group will undergo the same QL block procedure as the intervention arm, except saline (placebo) will be injected.",[13],"Procedure: Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"Quadratus Lumborum Block","EXPERIMENTAL","The Quadratus Lumborum block will be randomly administered to half of the study patients.",[19],"Procedure: Quadratus Lumborum (QL) Block",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Quadratus Lumborum (QL) Block","The intervention arm will receive bilateral quadratus lumborum blocks in the preoperative holding area prior to surgery. The syringe will contain a total of 60 mL of 0.25% Ropivacaine with 4 mg of Decadron. The anesthesiology pain team provider will administer 30 mL on the left side and 30 mL on the right side of the abdominal wall. The patient will receive one injection site per flank. During the procedure, the patient is placed in the left and then right lateral decubitus position and the ultrasound probe is placed above the iliac crest at the mid axillary line. The pain team provider will move the probe posteriorly to identify the \"shamrock sign.\" Under ultrasound guidance, a needle is inserted in an in- plane approach through the quadratus lumborum (QL) muscle until reaching the middle of the thoracolumbar fascia layer between QL and psoas muscle. After negative aspiration for blood, injection will allow the spread of local anesthetic between the QL and psoas muscle on each side.",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","The placebo control group will receive the same quadratus lumborum (QL) block procedure as the intervention group, with the only difference being the injection of 60 mL of saline instead of local anesthetic. The anesthesiology team will administer 30 mL on each side of the abdominal wall, with one injection site per flank. The patient will be positioned in the left and right lateral decubitus positions, and the ultrasound probe will be placed above the iliac crest at the mid-axillary line to identify the \"shamrock sign.\" The needle will be inserted through the QL muscle to the thoracolumbar fascia layer, between the QL and psoas muscle. After negative aspiration for blood, saline will be injected, allowing spread between the QL and psoas muscle on each side.",[9],[32],{"name":33,"affiliation":34,"role":35},"Kaela E Blake, MD","The University of Tennessee Graduate School of Medicine","PRINCIPAL_INVESTIGATOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","865-305-9620","kblake@utmck.edu",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Trey A Henderson, MSc","865-305-7540","thenderson@utmck.edu",[46],{"facility":47,"status":26,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"The University of Tennessee Medical Center","Knoxville","Tennessee","37920","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-83.92074,35.96064,{"lat":57,"lon":56},[60,62,66],{"name":61,"role":38,"phone":43,"phoneExt":26,"email":44},"Trey A Henderson, MD",{"name":63,"role":38,"phone":64,"phoneExt":26,"email":65},"Elizabeth A LaFontaine, BS, MBSCR, CNC","865-305-9662","ealafontaine@utmck.edu",{"name":67,"role":68,"phone":26,"phoneExt":26,"email":26},"Jason M Buehler, MD","SUB_INVESTIGATOR",{"type":70,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100589378","quadratus-lumborum-versus-placebo-in-open-ventral-hernia-repair-100589378",false,"NCT06953635","Quadratus Lumborum Versus Placebo in Open Ventral Hernia Repair","Quadratus Lumborum Blocks for Pain Control Following Open Ventral Hernia Repair: A Double Blinded Randomized Control Trial","VHR","Inclusion Criteria:\n\n1. \\>18 years of age\n2. Able to read and understand study procedures\n3. Willing to participate and sign an informed consent form\n4. Open approaches to ventral hernia repair\n5. Clean (CDC Class I), clean-contaminated (CDC Class II)\n6. Elective surgery\n7. Mesh placed in the retromuscular position\n\nExclusion Criteria:\n\n1. Dirty-Infected cases (CDC Class IV): Old traumatic wounds with retained devitalized tissue and those that involve existing clinical infection or perforated viscera\n2. Patient has a contraindication to receiving the drug and\u002For procedure: allergy\u002Fsensitivity to the drug, coagulopathy, abdominal wall infection at the drug administration site, systemic infection, anatomical distortion, neuropathy\n3. Emergent procedure\n4. Mesh not placed","ALL","18 Years",{"count":82,"type":83},70,"ESTIMATED","INTERVENTIONAL",[86],"NA","The purpose of this study is to determine whether using a QL block is better than placebo (a look-alike substance that contains no drug) in lowering the amount of opioids you need for pain relief in the first 24 hours and if it improves your recovery following a ventral hernia repair.\n\nParticipants will be asked to complete a questionnaire before surgery and again at their 30-day follow up. You will also be asked to complete a pain diary 24 hours after surgery and attend a follow-up visit approximately 30 days after surgery.\n\nThe following information will be collected from you or your medical record:\n\n1. Pain medications given to you during surgery.\n2. Pain medications prescribed to you after surgery, including medication name, dose, units, and frequency.\n3. Pain levels during the first 24 hours after surgery.\n4. Your total hospital length of stay after surgery.\n5. Any complications that you may have experienced after surgery.\n6. Demographic information, medical history as well as details about your hernia repair surgery.",[89,90],"Hernia, Ventral","Pain Management",[92,93,94],"Regional Anesthesia","Postoperative Pain","Ventral Hernia Repair","NOT_YET_RECRUITING","2025-04-29",{"date":98,"type":99},"2025-05-01","ACTUAL",{"date":101,"type":83},"2025-06-01",{"date":103,"type":83},"2026-02-28",{"name":5,"class":6},1]