[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610503":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":25,"centralContacts":29,"locations":38,"responsibleParty":53,"collaborators":55,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":10,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":10,"enrollmentInfo":68,"targetDuration":10,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":10,"overallStatus":41,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Yale University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Systemic sclerosis participants with calcinosis",null,"SSc participants with calcinosis treated with sodium thiosulfate STS per SOC over 6 months.",[13,14],"Drug: Sodium Thiosulfate (STS)","Drug: Sodium Thiosulfate Injection",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"DRUG","Sodium Thiosulfate (STS)","Calcinosis cutis treatment, 25% STS topical cream, Twice daily for 6 months",[9],{"type":17,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Sodium Thiosulfate Injection","calcinosis cutis treatment, 25% STS intradermal injection, once monthly for 6 months",[9],[26],{"name":27,"affiliation":5,"role":28},"Monique Hinchcliff, MD, MS","PRINCIPAL_INVESTIGATOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Crystal Cheung","CONTACT","203-737-5571","crystal.cheung@yale.edu",{"name":36,"role":32,"phone":10,"phoneExt":10,"email":37},"Diane Documet","diane.documet@yale.edu",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":10},"Yale Scleroderma Program","RECRUITING","New Haven","Connecticut","06520","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-72.92816,41.30815,{"lat":51,"lon":50},{"type":54,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[56],{"name":57,"class":58},"National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)","NIH","100610503","quantification-of-calcinosis-cutis-disease-burden-using-computed-tomography-images-100610503",false,"NCT07228429","Quantification of Calcinosis Cutis Disease Burden Using Computed Tomography Images","Quantification of Calcinosis Cutis Disease Burden in Patients With Systemic Sclerosis Using Computed Tomography Images","Inclusion Criteria:\n\n* Scleroderma\u002Fsystemic sclerosis patient with diagnosed calcinosis cutis who will be clinically treated with STS as they would in clinical SOC care\n* Must be ≥ 18 years old and meet the 2013 American College of Rheumatology criteria for the diagnosis of systemic sclerosis (diffuse or limited)\n* Receiving clinical care at Yale clinics\n\nExclusion Criteria:\n\n* Unable to provide informed consent\n* Currently pregnant or nursing\n* Patients with a calcinosis ROI \\>6cm","ALL","18 Years",{"count":69,"type":70},56,"ESTIMATED","OBSERVATIONAL","The main purpose of this study is to develop sensitive radiographic measurement techniques that can be used as outcome measures along with patient-reported outcome instruments in clinical trials of calcinosis cutis treatments, and potentially be used to assess disease course and treatment response in clinical practice. The goal is to test the performance of the software.",[74,75],"Systemic Sclerosis (SSc)","Calcinosis Cutis","2026-02-11",{"date":78,"type":79},"2026-02-17","ACTUAL",{"date":81,"type":79},"2025-10-14",{"date":83,"type":70},"2026-07",{"name":5,"class":6},1]