[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608551":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":26,"locations":33,"responsibleParty":52,"collaborators":55,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":31,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":31,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":83,"whyStopped":31,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Emory University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Anxiety and impairing levels of avoidance","EXPERIMENTAL","Participants are screened for anxiety and impairing levels of avoidance and will complete questionnaires, a clinical interview, behavioral tasks, scanning, ecological momentary assessment (EMA), and passive sensing. Participants will complete four visits total.",[13],"Behavioral: Behavioral Tasks with imaging",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Behavioral Tasks with imaging","Participants will complete the MDP task only during 3 separate fMRI scanning sessions.\n\nAfter each session, they will complete one week of ambulatory assessment of real-world avoidance behavior (self-reported avoidance behavior) via Emory Qualtrics surveys. In a fourth scanning session, the brain signature of threat imminence constructed in the first set of participants (Aim 1) will be used to predict and modify avoidance behavior (on the task and in a further week of ambulatory assessment of avoidance) in these participants. During their last visit, the behavioral task will be modified to decrease the availability of avoidance choices; subsequent effects on EMA and passive sensing measures will be assessed.",[9],[21],"Investigational",[23],{"name":24,"affiliation":5,"role":25},"Vanessa M Brown, PhD","PRINCIPAL_INVESTIGATOR",[27],{"name":28,"role":29,"phone":30,"phoneExt":31,"email":32},"Vanessa M. Brown, PhD","CONTACT","404-727-5454",null,"vanessa.m.brown@emory.edu",[34,47],{"facility":35,"status":31,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":31},"Emory College","Atlanta","Georgia","30322","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-84.38798,33.749,{"lat":45,"lon":44},{"facility":48,"status":31,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":49,"geoPoint":51,"contacts":31},"Facility for Education and Research in Neuroscience (FERN)",{"type":42,"coordinates":50},[44,45],{"lat":45,"lon":44},{"type":25,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Vanessa M. Brown","Assistant Professor",[56],{"name":57,"class":58},"National Institute of Mental Health (NIMH)","NIH","100608551","quantifying-multi-step-avoidance-in-anxiety-100608551",false,"NCT07203027","Quantifying Multi-step Avoidance in Anxiety","Quantifying Neural Signatures of Multi-step Avoidance Behavior in Anxiety","Inclusion Criteria:\n\n* Ability to comprehend written and spoken English\n* Ability to provide informed consent\n* Estimated intelligence quotient (IQ) \\>70.\n* Clinically significant anxiety symptoms (scoring above clinical cutoff on at least one Inventory of Depression and Anxiety Symptoms (IDAS) anxiety-related subscale and\u002For OASIS total)\n* Significant anxiety-related avoidance (scoring 2 or above on a 0-4 scale, indicating at least \"occasional\" avoidance) on the avoidance-related question on the Overall Anxiety Severity and Impairment Scale (OASIS)\n* Functional impairment, defined as at least moderate impairment in one WHO Disability Assessment Schedule (WHODAS 2.0) domain related to anxiety.\n\nExclusion Criteria:\n\n* Individuals younger than 22 or older than 55,\n* Individuals with an IQ \\\u003C 70,\n* A lifetime history of neurological disorder or brain damage,\n* Contraindications for undergoing MRI scanning,\n* A lifetime history or diagnosis of psychosis or bipolar disorder,\n* Current substance use intoxication or withdrawal,\n* Severe risk of suicide, or\n* Recent (\\\u003C3 months) changes in psychotropic medicine or psychotherapy treatment,\n* Ineligible at the PI's discretion, are excluded.",true,"ALL","22 Years","55 Years",{"count":71,"type":72},163,"ESTIMATED","INTERVENTIONAL",[75],"NA","This study aims to learn more about avoidance behavior in people with anxiety, using mathematical models of decision-making processes and decoded neural signals of threat imminence.\n\nResearchers are investigating anxiety-related behavior and brain function in people with and without anxiety. Investigators are also looking at how behavior and brain function during tasks in the lab relate to avoidance in their daily lives. The investigators will also test whether changing how people avoid things in a behavioral task affects how people avoid things in their everyday life.",[78,79],"Anxiety","Anxiety Disorders",[81,82],"Avoidance behavior","Fear learning","NOT_YET_RECRUITING","2026-05-05",{"date":86,"type":87},"2026-05-07","ACTUAL",{"date":89,"type":72},"2027-01",{"date":91,"type":72},"2030-06",{"name":5,"class":6},2]