[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635145":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":45,"collaborators":47,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":20,"enrollmentInfo":60,"targetDuration":20,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":72,"whyStopped":20,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"St. Anne's University Hospital Brno, Czech Republic","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Arm","EXPERIMENTAL","Patients clinically indicated for non-invasive exclusion of ischemic heart disease (IHD) will be enrolled in the study. All participants will undergo stress myocardial perfusion MRI in accordance with ESC (European Society of Cardiology) guidelines. The examination will form part of a standard cardiac MRI protocol. During the procedure, a vasoactive agent will be administered as part of routine clinical care, in accord current standards and recommendations. A quantitative and semi-quantitative analysis of myocardial blood flow will be performed from the acquired data, and the results of both analyses will be compared. In patients with documented perfusion abnormalities, selective coronary angiography will be performed in accordance with standard clinical practice. In cases of inconclusive test results, an additional stress test (e.g., myocardial scintigraphy) or CT coronary angiography will be performed.",[13],"Diagnostic Test: Magnetic Resonance Imaging with Contrast",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIAGNOSTIC_TEST","Magnetic Resonance Imaging with Contrast","Myocardial perfusion will be conducted according to the standard ESC perfusion protocol, using Gadolinium-based contrast agent (Gadovist) at a dose of 0.1 mmol\u002Fkg (0.1 ml\u002Fkg) administered at 3-5 ml\u002Fs, followed by 20 ml of saline flush. The contrast agent will be divided into two equal doses for stress and rest perfusion (0.05 ml\u002Fkg per perfusion). The stress agents used will be Adenosine (short-term infusion at 140 µg\u002Fkg\u002Fmin using an infusion pump) or Regadenoson (400 µg intravenous bolus).\n\nPatients with relative or absolute contraindications to stress testing will be excluded from the study, including those with acute coronary syndrome, life-threatening arrhythmias, severe COPD, second- or third-degree AV block, and patients with contraindications to MRI (ferromagnetic implants, severe renal failure, pregnancy).",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Roman Panovský, MD","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","+420 543 18 2409","panovsky@fnusa.cz",[31],{"facility":32,"status":20,"city":33,"state":20,"zip":34,"country":35,"countryCode":20,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"St. Anne´s University Hospital Brno","Brno","60200","Czechia",{"type":37,"coordinates":38},"Point",[39,40],16.60796,49.19522,{"lat":40,"lon":39},[43,44],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},{"name":23,"role":24,"phone":20,"phoneExt":20,"email":20},{"type":46,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[48],{"name":49,"class":50},"Philips Medical Systems","INDUSTRY","100635145","quantitative-analysis-of-cardiac-muscle-perfusion-100635145",false,"NCT07548879","Quantitative Analysis of Cardiac Muscle Perfusion","KAPSS","Inclusion Criteria:\n\n* Signed informed consent\n* Patients indicated for a non-invasive test for ischemic heart disease\u002Fchronic coronary syndrome\n* Patients with intermittent chest pain and low to moderate probability of chronic coronary syndrome\n\nExclusion Criteria:\n\n* Presence of relative or absolute contraindications to stress testing, including acute coronary syndrome, life-threatening arrhythmias, severe chronic obstructive pulmonary disease (COPD), or second- or third-degree atrioventricular (AV) block.\n* Contraindications to MRI, such as severe claustrophobia, presence of ferromagnetic material or implants, or severe renal impairment.","ALL","18 Years",{"count":61,"type":62},35,"ESTIMATED","INTERVENTIONAL",[65],"NA","Full quantitative perfusion of the myocardial wall using MRI is a difficult method for several reasons. First the perfusion algorithm is mostly only relatively available, usually available algorithms \u002Fe.g. ISP\u002F shows not precise results according to our measurements, secondly based on signal physics and nature of MRI scans is not easy to get absolute numbers and specific new algorithms must be developed and tested. Such a tool is not only needed for some special cohort of patients, like 3-vessel disease, coronary artery disease or diffuse coronary artery involvement in coronary vasculopathy in patients after heart transplantation. Fully quantitative perfusion analysis is highly needed for nearly all cardiac patients to better characterise the health and status of the myocardium.",[68],"Myocardial Ischemia",[70,71],"Fully quantitative stress perfusion","CMR","NOT_YET_RECRUITING","2026-04-16",{"date":75,"type":76},"2026-04-23","ACTUAL",{"date":78,"type":62},"2026-06-01",{"date":80,"type":62},"2029-12-30",{"name":5,"class":6},1]