[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593738":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":30,"responsibleParty":58,"collaborators":10,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":10,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":10,"maxAge":10,"enrollmentInfo":69,"targetDuration":10,"studyType":72,"phases":10,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":51,"whyStopped":10,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Fujian Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Derivation_Cohort",null,"The model-development cohort consisted of 500 consecutive patients drawn from the Thyroid Surgery Department database of Fujian Medical University Union Hospital (Fuzhou, China)",[13],"Diagnostic Test: ntra-operative Indocyanine Green (ICG) Fluorescence Quantification",{"label":15,"type":10,"description":16,"interventionNames":17},"Validation_Cohort","The external validation cohort comprised 300 patients",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","ntra-operative Indocyanine Green (ICG) Fluorescence Quantification","After a single intravenous bolus of indocyanine green (25 µg\u002Fkg), a near-infrared sensor records raw fluorescence intensity from the superior parathyroid gland and the ipsilateral common carotid artery at 60-120 seconds. No images are stored; only peak intensity values are logged to calculate the perfusion ratio R = PTG \u002F CCA. The measurement is observational, adds ≤2 minutes to operative time, and involves no therapeutic intent.",[9,15],[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Bo Wang, MD","CONTACT","+13959123550","wangbo@fjmu.edu.cn",[31,50],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Fujian Medical University Union Hospital","NOT_YET_RECRUITING","Fuzhou","Fujian","350001","China","CN",{"type":40,"coordinates":41},"Point",[42,43],119.30611,26.06139,{"lat":43,"lon":42},[46,47],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},"Bo Wang MD, Principal Investigator","PRINCIPAL_INVESTIGATOR",{"facility":32,"status":51,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":52,"geoPoint":54,"contacts":55},"RECRUITING",{"type":40,"coordinates":53},[42,43],{"lat":43,"lon":42},[56],{"name":26,"role":27,"phone":57,"phoneExt":10,"email":29},"+86 13959123550",{"type":49,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Bo Wang,MD","Director, Head of Thyroid Surgery, Principal Investigator, Clinical Professor","100593738","quantitative-intra-operative-assessment-of-parathyroid-perfusion-using-indocyanine-green-icg-fluorescence-imaging-100593738",false,"NCT07010341","Quantitative Intra-operative Assessment of Parathyroid Perfusion Using Indocyanine Green (ICG) Fluorescence Imaging","Quantitative Intra-operative Assessment of Parathyroid Perfusion Using Indocyanine Green (ICG) Fluorescence Imaging: A Prospective Observational Study","Inclusion Criteria:\n\n* Scheduled for unilateral thyroid lobectomy plus central (VI-level) lymph-node dissection.\n* Intra-operative findings consistent with:\n* Complete identification and in-situ preservation of the ipsilateral superior parathyroid gland;\n* Complete identification and autotransplantation of the ipsilateral inferior parathyroid gland.\n* Serum 25-hydroxy-vitamin D ≥ 30 ng\u002FmL at baseline; patients below this level may be enrolled after standardized vitamin-D and calcium supplementation with re-test confirming ≥ 30 ng\u002FmL.\n* Surgery and all postoperative follow-up performed at the study center.\n* Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Prior surgery on the thyroid or parathyroid glands.\n* Severe hepatic or renal impairment, or other serious metabolic bone disease.\n* Pregnancy or lactation.\n* Known hypersensitivity to indocyanine green or iodine-containing compounds.\n* Inability or unwillingness to comply with postoperative visits and blood testing.","ALL",{"count":70,"type":71},210,"ESTIMATED","OBSERVATIONAL","This single-center, prospective, three-phase observational cohort quantifies the relationship between indocyanine green (ICG) fluorescence and early parathyroid function. Adult patients scheduled for unilateral thyroid lobectomy with autotransplantation of the ipsilateral inferior parathyroid gland are enrolled. After intravenous ICG 25 µg\u002Fkg, peak fluorescence of the superior parathyroid gland and the common carotid artery (CCA) is recorded at 60-120 seconds to calculate the ratio R = PTG\u002FCCA. Serum parathyroid hormone (PTH) is measured 30 minutes post-operatively. A derivation cohort (\\~120 patients) generates R-based thresholds for in-situ preservation versus autotransplantation, which are prospectively validated in an independent cohort (60 patients) together with decision-curve analysis of clinical net benefit.",[75],"Thyroid Surgery",[77,78,79,80,81,82,83],"Thyroid surgery","Indocyanine Green","Near-Infrared Fluorescence","Parathyroid Perfusion","Perfusion Threshold","Hypocalcemia","Perfusion Ratio","2025-07-12",{"date":86,"type":87},"2025-07-15","ACTUAL",{"date":89,"type":87},"2025-05-01",{"date":91,"type":71},"2026-05-31",{"name":5,"class":6},2]