[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100579065":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":27,"centralContacts":32,"locations":42,"responsibleParty":67,"collaborators":37,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":37,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":37,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":37,"overallStatus":45,"whyStopped":37,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"South Valley University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A: Leprosy Patients","ACTIVE_COMPARATOR","About 40 patients suffering from Leprosy and will treated by Multi drug therapy as ( dapsone \\_ clofazimine \\_ rifampcin) then to assess the role of Rab 32 gene.by taking Two millimetres of venous blood from each participant At the end of third month therapy.",[13],"Drug: Dapsone",{"label":15,"type":10,"description":16,"interventionNames":17},"Group B: Healthy People","About 10 Healthy People. no drugs used and then to assess the role of Rab 32 gene.by taking Two millimetres of venous blood from each participant",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Dapsone","To evaluate the effect of the multi drug therapy in leprotic patients and their side effects and to assess the role of Rab 32 gene in leprosy prognosis and to know its association with the multi drug therapy.",[9,15],[25,26],"clofazimine","rifampcin",[28],{"name":29,"affiliation":30,"role":31},"Eisa Mohammed Hegazy, Assist. Prof","Dermatology, Venereology and Andrology. Faculty of Medicine,South Valley University","STUDY_CHAIR",[33,39],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Lydia Atef Nassief, MSc","CONTACT","+201289416276",null,"lydiaatef67@gmail.com",{"name":29,"role":35,"phone":40,"phoneExt":37,"email":41},"+201094337795","eisa_mohamed4152@med.svu.edu.eg",[43],{"facility":44,"status":45,"city":46,"state":37,"zip":37,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Qina University hospital, South Valley University Hospital","RECRUITING","Qina","Egypt","EG",{"type":50,"coordinates":51},"Point",[52,53],32.72671,26.16418,{"lat":53,"lon":52},[56,60,64],{"name":57,"role":35,"phone":58,"phoneExt":37,"email":59},"Mohammed Hosny Hassan, Professor","+201098473605","mohammedhosnyhassaan@med.svu.edu.eg",{"name":61,"role":35,"phone":62,"phoneExt":37,"email":63},"Soheir Abdel-hamid Ali, M.D","+201066877343","Soher.abdel-hamid@med.svu.edu.eg",{"name":65,"role":66,"phone":37,"phoneExt":37,"email":37},"Ebtehal Alaa El-din Kotp Mohammed, M.D","PRINCIPAL_INVESTIGATOR",{"type":66,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":37,"oldOrganization":37},"Lydia Atef Nassief","Resident of Dermatology , venereology and andrology at Faculty of medicine","100579065","rab-32-gene-polymorphisms-as-a-prognostic-factor-in-leprosy-patients-100579065",false,"NCT06819449","Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients","Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients and Its Relation to Multiple Drug Therapy: Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients of both sexes with positive slit skin smear for m.leprae .\n\nExclusion Criteria:\n\n* Contraindications to Multi drug therapy :\n* Patients with hypersensitivity to sulfa .\n* Patients with hypersensitivity to clofazimine or rifampcin.\n* pregnant or lactating women.","ALL","5 Years","60 Years",{"count":81,"type":82},50,"ESTIMATED","INTERVENTIONAL",[85],"NA","Mycobacterium leprae is a slow-growing bacillus that causes leprosy. the infection may take two to ten years to incubate. While the exact mechanism of infection transmission is unknown, direct bacillus absorption through the nasal or respiratory mucosa and aerosolized nasal secretions are the most common theories. The bacteria is subsequently transported by the bloodstream to the peripheral nerves, where it can result in tissue damage from painless burns and ulcers as well as irreparable nerve damage that results in a loss of protective feeling.",[88,89],"Leprosy","Mycobacterium Leprae Infection","2025-02-04",{"date":92,"type":93},"2025-02-11","ACTUAL",{"date":95,"type":93},"2024-12-20",{"date":97,"type":82},"2025-12-20",{"name":5,"class":6},1]