[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100530354":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":27,"centralContacts":31,"locations":36,"responsibleParty":61,"collaborators":63,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":10,"eligibilityCriteria":77,"healthyVolunteers":73,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":10,"studyType":84,"phases":10,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Washington University School of Medicine","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Brain tumor patients receiving proton radiation therapy",null,"Patients between 8 and 21 years old (inclusive) with a newly diagnosed primary brain tumor that will be treated with proton radiation therapy",[13,14],"Other: Cognitive testing","Device: Resting State MRI\u002FPrecision functional mapping",[16,20],{"type":6,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"Cognitive testing","NIH Toolbox Cognitive Battery and the Novel Cognitive Measure (NCM)",[9],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Resting State MRI\u002FPrecision functional mapping","At baseline (before the end of radiation therapy) and approximately 12 months after the completion of radiation therapy.",[9],[26],"RSFC MRI",[28],{"name":29,"affiliation":5,"role":30},"Stephanie Perkins, M.D.","PRINCIPAL_INVESTIGATOR",[32],{"name":29,"role":33,"phone":34,"phoneExt":10,"email":35},"CONTACT","314-747-4405","sperkins@wustl.edu",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Washington University School of Medicine\u002FSaint Louis Children's Hospital","RECRUITING","St Louis","Missouri","63110","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-90.19789,38.62727,{"lat":49,"lon":48},[52,53,54,57,59],{"name":29,"role":33,"phone":34,"phoneExt":10,"email":35},{"name":29,"role":30,"phone":10,"phoneExt":10,"email":10},{"name":55,"role":56,"phone":10,"phoneExt":10,"email":10},"Scott Marek, Ph.D.","SUB_INVESTIGATOR",{"name":58,"role":56,"phone":10,"phoneExt":10,"email":10},"Joshua Shimony, M.D., Ph.D.",{"name":60,"role":56,"phone":10,"phoneExt":10,"email":10},"Margaret Shatara, M.D.",{"type":62,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[64,67,69],{"name":65,"class":66},"United States Department of Defense","FED",{"name":68,"class":6},"The Foundation for Barnes-Jewish Hospital",{"name":70,"class":6},"Children's Cancer Research Fund","100530354","radiation-induced-alterations-in-resting-state-brain-networks-in-pediatric-brain-tumor-patients-100530354",false,"NCT06185686","Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients","Assessing Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients","Inclusion Criteria:\n\n* Between 8 and 21 years of age, inclusive\n* Newly diagnosed primary brain tumor of any location and any histology that will be treated with proton radiation therapy\n* Life expectancy of at least one year\n* Able to understand and willing to consent or assent to the research proposed (or that of a legally authorized representative, if applicable), along with consent of legal guardian(s) if applicable\n\nExclusion Criteria:\n\n* Presence of visual impairment to an extent that the patient is unable to complete the computer testing\n* Contraindication to MRI scan (i.e. due to cardiac pacemaker)\n* Presence of programmable shunt or dental braces\n* Requires sedation for MRI scans","ALL","8 Years","21 Years",{"count":82,"type":83},16,"ESTIMATED","OBSERVATIONAL","With modern therapy, the survival rate for pediatric brain tumor patients has significantly improved, with over 70% of patients surviving their disease. However, this progress often comes at the cost of substantial morbidity, with cognitive deficits being the primary obstacle to independent living. Robust predictors of cognitive decline and a comprehensive understanding of the underlying mechanisms of cognitive injury remain elusive. This study will prospectively investigate alterations in brain resting state networks following radiation therapy using functional imaging. The hypothesis is that radiation therapy leads to dose-dependent alterations in functional connectivity in the networks associated with higher level cognition, ultimately leading to cognitive decline.",[87],"Brain Tumor, Primary",[89,90,91],"Proton therapy","Radiation","Brain tumor","2025-07-15",{"date":94,"type":95},"2025-07-18","ACTUAL",{"date":97,"type":95},"2024-07-10",{"date":99,"type":83},"2027-07-31",{"name":5,"class":6},1]