[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591889":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":20,"centralContacts":25,"locations":30,"responsibleParty":46,"collaborators":19,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":51,"sex":57,"minAge":58,"maxAge":19,"enrollmentInfo":59,"targetDuration":19,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":70,"overallStatus":79,"whyStopped":19,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Technische Universität Dresden","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Diagnostic","Patients with non-small cell lung or esophageal cancer (cohort 1) or with breat cancer (cohort 2)",[12],"Diagnostic Test: Imaging and biomarkers",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"DIAGNOSTIC_TEST","Imaging and biomarkers","MR imaging of the heart, ECG and TTE measurements, blood sample",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Esther G. C. Troost, Prof. Dr. med. Dr.","Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany","PRINCIPAL_INVESTIGATOR",[26],{"name":22,"role":27,"phone":28,"phoneExt":19,"email":29},"CONTACT","+49 351 458 2238","esther.troost@uniklinikum-dresden.de",[31],{"facility":32,"status":19,"city":33,"state":34,"zip":35,"country":34,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"University of Technology, University Hospital Carl Gustav Carus, Department of Radiation Therapy and Radiation Oncology","Dresden","Germany","01304","DE",{"type":38,"coordinates":39},"Point",[40,41],13.73832,51.05089,{"lat":41,"lon":40},[44],{"name":22,"role":27,"phone":28,"phoneExt":19,"email":45},"str.studien@uniklinikum-dresden.de",{"type":24,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Prof. Esther Troost","Prof. Dr. med. Dr.","100591889","radiation-induced-toxicity-of-the-heart-100591889",false,"NCT06986291","Radiation-induced Toxicity of the Heart","Quantitative Assessment of Radiation-induced Toxicity of the Heart","CorTox","Inclusion Criteria:\n\n* Patients 18 years old or older\n* Patient's consent and written consent is available\n* Patients with the non-small cell lung cancer or esophageal cancer or breast cancer who have an indication for intended curative radio(chemo)therapy (in the case of breast cancer inclusion of female patients only)\n\nExclusion Criteria:\n\n* Patients who are not capable of giving consent\n* Pregnant women\n* Patients with contraindications for MRI examinations (pacemakers, defibrillators, neurostimulators, aneurysm clips, cochlear implants, permanent make-up, metal splinters or osseosynthetic implants)\n* Patients with insufficient kidney function (glomerular filtration rate (GFR) of less than 30 ml\u002Fmin)\n* Patients with the aforementioned tumour entities for whom a palliative indication exists","ALL","18 Years",{"count":60,"type":61},325,"ESTIMATED","INTERVENTIONAL",[64],"NA","Late side effects in radio(chemo)therapy \\[R(CH)T\\] pose a critical limitation to patients' overall survival and quality of life. Even though toxicities of the heart are highly relevant for patients with cancer in the thoracic region, risk stratification models for these toxicities are lacking. In this study, liquid, functional and imaging biomarkers are being investigated for their use in prediction of cardiac toxicity following R(CH)T for patients with thoracic malignancies.",[67,68,69],"Non-small Cell Lung Cancer","Esophageal Cancer","Breast Cancer Female",[71,72,73,74,75,76,77,78],"Non-small cell lung cancer","Esophageal cancer","Breast cancer","Cardiotoxicity","Radio(chemo)therapy","MRI","Cardiac function test","Omics analyses","NOT_YET_RECRUITING","2025-05-22",{"date":82,"type":83},"2025-05-29","ACTUAL",{"date":85,"type":61},"2025-08",{"date":87,"type":61},"2039-12",{"name":5,"class":6},1]