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Female patient with a new histological diagnosis of clinical T1-3 N0 breast cancer (any tumour sub-type).\n2. Negative lymph node involvement at initial presentation, documented by imaging (US or MRI), fine needle aspiration (FNA) or core needle biopsy.\n3. Treated with a minimum of 8 weeks NAC, with patients with Her2+ disease receiving targeted anti-Her2+ therapy.\n4. Marker clip placed in the tumour bed prior to or during neoadjuvant chemotherapy when the tumour can still be identified.\n5. Treated by BCS with complete excision of the tumour bed and axillary staging surgery (either sentinel lymph node biopsy or axillary lymph node dissection).\n6. Final pathology demonstrating a pCR \\[defined as absence of residual invasive and in-situ breast cancer within the breast or lymph nodes (ypT0N0)\\].\n\nExclusion Criteria:\n\n1. Age less than 50 years.\n2. Inflammatory breast cancer or breast cancer invading the skin or chest wall (T4 disease).\n3. 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