[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584322":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":36,"locations":42,"responsibleParty":58,"collaborators":25,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":25,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":25,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":25,"overallStatus":44,"whyStopped":25,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low dose radiotherapy","ACTIVE_COMPARATOR","Low dose radiation therapy for knee osteoarthritis",[13],"Radiation: Low dose radiotherapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","SHAM_COMPARATOR","No radiation therapy",[19],"Other: Sham comparator",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"RADIATION","Participants will receive low dose radiotherapy (0.5 Gy) 3 times per week, for two weeks delivered via the X-Strahl Orthovoltage device.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Sham comparator","Participants will receive identical treatment 3 times per week, for two weeks delivered via the X-Strahl Orthovoltage device, without radiation.",[15],[31,34],{"name":32,"affiliation":5,"role":33},"Stephen P. Merry, M.D.","PRINCIPAL_INVESTIGATOR",{"name":35,"affiliation":5,"role":33},"Paul D. Brown, M.D.",[37],{"name":38,"role":39,"phone":40,"phoneExt":25,"email":41},"Family Medicine Research Study Coordinators","CONTACT","507-422-6823","RSTFMSC@mayo.edu",[43],{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-92.4699,44.02163,{"lat":54,"lon":53},[57],{"name":38,"role":39,"phone":40,"phoneExt":25,"email":41},{"type":33,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Stephen P. Merry","Principal Investigator","100584322","radio--ko-radiotherapy-for-knee-osteoarthritis-clinical-trial-100584322",false,"NCT06887829","Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial","The Randomized Clinical Trial of Low-Dose Radiotherapy for Knee Osteoarthritis","Inclusion Criteria:\n\n* • patient's primary care provider is at Mayo Clinic in Rochester, MN\n\n  * age 50-100 years\n  * ICOAP pain scale A1 at least moderate intensity or B6 at least moderate intensity\n  * diagnosed with primary knee OA ICD-10 codes M17.x\n\n    o You have not had recurrent episodes of sudden onset of warmth, redness, or swelling of the affected knee\n  * physical exam findings of medial or lateral joint line tenderness on palpation that is in the same location as the knee pain.\n  * absence of primary knee pain in the pes anserine or hamstring or gastrocnemius, quadriceps, or patellar tendons on exam.\n  * radiographic Kellgren-Lawrence grade 2-3 on 4-view knee x-rays taken within the last year ability to complete surveys electronically by email\n\nExclusion Criteria:\n\n* • Kellgren-Lawrence grade 1 or 4\n\n  * pregnancy or women 54 years and younger with potential for pregnancy (if they or their partner have not had tubal ligation, hysterectomy, or vasectomy)\n  * history of ipsilateral intraarticular knee surgery\n  * use of injected corticosteroids within 3 months or hyaluronans within 6 months or within 1 month if there was no sustained improvement post-injection of either corticosteroid or hyaluronan.\n  * history of trauma to this knee in the last year that clearly caused the pain now present\n  * history of RA, gout, pseudogout, hemarthroses (eg, hemophilic arthropathy) or other inflammatory arthritis involving this knee\n  * history of symptomatic hip OA\n  * history of psychosis, personality disorder, uncontrolled affective disorder\n  * history of fibromyalgia\n  * malignancy requiring active treatment current regular use of opiate analgesics, PRP, or acupuncture for the knees","ALL","50 Years","100 Years",{"count":72,"type":73},128,"ESTIMATED","INTERVENTIONAL",[76],"NA","The primary aim of this study is to investigate whether low-dose radiotherapy is an effective treatment to reduce the pain of knee osteoarthritis. A secondary aim is to determine whether patients experience any more measurable side effects than those receiving sham treatments.",[79],"Osteoarthritis, Knee","2026-06-10",{"date":82,"type":83},"2026-06-12","ACTUAL",{"date":85,"type":83},"2025-06-04",{"date":87,"type":73},"2026-06-29",{"name":5,"class":6},1]