[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601091":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":7,"responsibleParty":14,"collaborators":7,"id":17,"slug":18,"hasResults":19,"nctId":20,"briefTitle":21,"officialTitle":22,"acronym":7,"eligibilityCriteria":23,"healthyVolunteers":19,"sex":24,"minAge":25,"maxAge":26,"enrollmentInfo":27,"targetDuration":7,"studyType":30,"phases":7,"briefSummary":31,"conditions":32,"keywords":7,"overallStatus":34,"whyStopped":7,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":7},{"fullName":5,"class":6},"Nanjing First Hospital, Nanjing Medical University","OTHER",null,[9],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Feng Wang","CONTACT","+8602552271491","fengwangcn@hotmail.com",{"type":15,"investigatorFullName":10,"investigatorTitle":16,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Chief physician","100601091","radiolabeled-tspo-targeted-molecular-probe-in-ami-100601091",false,"NCT07105982","Radiolabeled TSPO Targeted Molecular Probe in AMI","Clinical Application of a Novel Radiolabeled Translocator Protein (TSPO) Targeted Small Molecular Probe in Inflammation Imaging of Acute Myocardial Infarction","Inclusion Criteria:\n\n* Volunteers, patients, or their legal representatives must sign the informed consent form and be able to cooperate with the PET-MR examination by lying flat for more than 30 minutes and maintaining a stable position.\n* No gender restrictions; age between 18 and 75 years, inclusive.\n* Patients must meet the diagnostic criteria for acute myocardial infarction (AMI), such as elevated myocardial enzyme spectrum, dynamic changes in electrocardiogram, or confirmation by coronary angiography.\n* Patients who are 7 to 10 days post-onset of acute myocardial infarction.\n* Renal GFR \\> 50 ml\u002Fmin; ERPF \\> 280 ml\u002Fmin; platelet count (PLT) \\> 75,000\u002FμL; white blood cells (WBC) \\> 3,000\u002FμL; alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels less than three times the upper limit of normal.\n\nExclusion Criteria:\n\n* Individuals with a history of allergy to similar drugs (drugs with similar chemical or biological components to TSPO), a history of allergies, or currently suffering from allergic diseases.\n* Use of anti-inflammatory drugs (such as corticosteroids or immunosuppressants) within the last 14 days, which may affect inflammation imaging.\n* Hemodynamically unstable conditions (such as cardiogenic shock or severe arrhythmias); Recent cerebral hemorrhage or severe bleeding tendency within the last 30 days.\n* Red blood cell count (RBC) \\\u003C 4×10\\^12\u002FL, white blood cell count (WBC) \\\u003C 3×10\\^9\u002FL, hemoglobin less than 110 g\u002FL, platelet count (PLT) \\\u003C 75×10\\^9\u002FL.\n* Significant abnormal liver or kidney function, with glomerular filtration rate (GFR) less than 50 ml\u002Fmin.\n* Presence of ferromagnetic metals implanted in the body (such as cardiac pacemakers, artificial heart valves, metal stents, etc.).\n* Claustrophobia or inability to tolerate prolonged examinations.\n* Presence of severe acute concomitant diseases or severe refractory mental disorders.\n* Pregnant or breastfeeding women (pregnancy defined as a positive urine pregnancy test).\n* Patients whose physical condition contraindicates radioactive examinations, such as severe cardiopulmonary insufficiency or other conditions deemed unsuitable by the investigator.\n* Other circumstances deemed unsuitable for participation in the trial by the researcher.","ALL","18 Years","75 Years",{"count":28,"type":29},8,"ESTIMATED","OBSERVATIONAL","Evaluate the clinical application value of the novel radiolabeled TSPO-targeted molecular probe Gallium \\[68Ga\\]-DOTA-HK-011 for inflammation imaging associated with acute myocardial infarction.",[33],"Acute Myocardial Infarction (AMI)","NOT_YET_RECRUITING","2025-07-30",{"date":37,"type":38},"2025-08-06","ACTUAL",{"date":40,"type":29},"2025-09-01",{"date":42,"type":29},"2026-08-31",{"name":5,"class":6}]