[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606326":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":10,"centralContacts":28,"locations":37,"responsibleParty":117,"collaborators":119,"id":122,"slug":123,"hasResults":124,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":10,"eligibilityCriteria":128,"healthyVolunteers":124,"sex":129,"minAge":130,"maxAge":10,"enrollmentInfo":131,"targetDuration":10,"studyType":134,"phases":10,"briefSummary":135,"conditions":136,"keywords":141,"overallStatus":56,"whyStopped":10,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":156},{"fullName":5,"class":6},"Azienda Unita Sanitaria Locale di Piacenza","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Rheumatoid arthritis-interstitial lung disease group",null,"Patients with rheumatoid arthritis related interstitial lung disease undergoing to HRCT at any time of their clinical history",[13],"Diagnostic Test: High resolution computed tomography",{"label":15,"type":10,"description":16,"interventionNames":17},"Idiopathic pulmonary fibrosis","Patients with idiopathic pulmonary fibrosis underoging to HRCT at any time of their clincial history",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Connective tissue disease - interstitial lung disease","Patients with connective tissue diseases related interstitial lung disease undergoing to HRCT at any time of their clinical history",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"DIAGNOSTIC_TEST","High resolution computed tomography","High resolution computed tomography perfomed in patients with rheumatoid arthritis and connective tissue diseases with or without interstitial lung disease, and idiopathic pulmonary fibrosis",[19,15,9],[29,34],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Marco Sebastiani, MD","CONTACT","+39 0523302645","m.sebastiani@ausl.pc.it",{"name":35,"role":31,"phone":32,"phoneExt":10,"email":36},"Francesca Cozzini, M.D.","f.cozzini@ausl.pc.it",[38,54,73,88,102],{"facility":39,"status":40,"city":41,"state":10,"zip":10,"country":42,"countryCode":10,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Institute of Rheumatology, Na Slupi 4","NOT_YET_RECRUITING","Prague","Czechia",{"type":44,"coordinates":45},"Point",[46,47],14.42076,50.08804,{"lat":47,"lon":46},[50],{"name":51,"role":31,"phone":52,"phoneExt":10,"email":53},"Jiří Vencovský","+420 224 914 469","vencovsky@revma.cz",{"facility":55,"status":56,"city":57,"state":10,"zip":10,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"UOC Reumatologia, Arcipedale Sant'Anna","RECRUITING","Ferrara","Italy","IT",{"type":44,"coordinates":61},[62,63],11.62057,44.83804,{"lat":63,"lon":62},[66,70],{"name":67,"role":31,"phone":68,"phoneExt":10,"email":69},"Andrea Lo Monaco","+039 0532 236314","lmnndr@unife.it",{"name":71,"role":72,"phone":10,"phoneExt":10,"email":10},"Andrea Lo Monaco, MD","PRINCIPAL_INVESTIGATOR",{"facility":74,"status":56,"city":75,"state":10,"zip":10,"country":58,"countryCode":59,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"SC Malattie Apparato Respiratorio, Azienda Policlinico di Modena","Modena",{"type":44,"coordinates":77},[78,79],10.92539,44.64783,{"lat":79,"lon":78},[82,86],{"name":83,"role":31,"phone":84,"phoneExt":10,"email":85},"Stefania Cerri","+090594222111","stefania.cerri@unimore.it",{"name":87,"role":72,"phone":10,"phoneExt":10,"email":10},"Stefania Cerri, prof",{"facility":89,"status":56,"city":90,"state":10,"zip":91,"country":58,"countryCode":59,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Local Health Unit (\"Azienda Unità Sanitaria Locale\", AUSL) of Piacenza","Piacenza","29121",{"type":44,"coordinates":93},[94,95],9.69342,45.05242,{"lat":95,"lon":94},[98,100],{"name":30,"role":31,"phone":10,"phoneExt":10,"email":99},"marco.sebastiani@unipr.it",{"name":101,"role":31,"phone":10,"phoneExt":10,"email":36},"Francesca Cozzini, MD",{"facility":103,"status":56,"city":104,"state":10,"zip":10,"country":58,"countryCode":59,"cosmosGeoPoint":105,"geoPoint":109,"contacts":110},"AUSL-IRCCS di Reggio Emilia","Reggio Emilia",{"type":44,"coordinates":106},[107,108],10.63125,44.69825,{"lat":108,"lon":107},[111,115],{"name":112,"role":31,"phone":113,"phoneExt":10,"email":114},"Andreina Manfredi, MD","+390522 296684","a.manfredi@unimore.it",{"name":116,"role":72,"phone":10,"phoneExt":10,"email":10},"Andreina prof. Manfredi",{"type":118,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[120],{"name":121,"class":6},"University of Parma","100606326","radiologic-features-of-rheumatoid-arthritis-interstitial-lung-disease-at-chest-high-resolution-computed-tomography-100606326",false,"NCT07174102","Radiologic Features of Rheumatoid Arthritis Interstitial Lung Disease at Chest High Resolution Computed Tomography","Radiologic Features of Patients With Rheumatoid Arthritis Related Interstitial Lung Disease at Chest High Resolution Computed Tomography","Inclusion Criteria:\n\n* patients able to give their informed consent\n* at least aged 18 years\n* patients undergoing High-Resolution Computed Tomography (HRCT) for clinical needs at any point in their medical history\n* patients with a diagnosis of rheumatoid arthritis, idiopathic pulmonary fibrosis or connective tissue disease\n\nExclusion criteria:\n\nPatients younger than 18 and unable to give their informed consent.","ALL","18 Years",{"count":132,"type":133},500,"ESTIMATED","OBSERVATIONAL","Lung involvement is one of the most frequent extra articular involvements of rheumatoid arthritis (RA). RA related lung involvement can affect parenchyma, airway, vascular tree and serosa. Among all possible manifestations of lung disease, interstitial lung disease is the most severe being able to compromise quality of life and survival and involves about 20% of patients with rheumatoid arthritis (RA). However, chest high resolution computed tomography (HRCT) features of RA, with or without interstitial lung involvement, have not been clearly defined. Such features have been mostly investigated on small populations of RA patients, often including patients with connective tissue diseases (CTDs), namely systemic sclerosis, mixed connective tissue disease, idiopathic inflammatory myopathies, making difficult to discriminate possible specific features of RA interstitial lung disease (ILD).\n\nThe aims of this observational longitudinal study are to investigate: i) chest HRCT features of RA (frequency of radiologic HRCT patterns, fibrosis, nodules, bronchiectasis, etc.), associated or not to ILD; ii) possible associations between chest HRCT features and demographic, clinical and serologic characteristics of RA; iii) specific chest HRCT features of RA ILD, compared to idiopathic pulmonary fibrosis (IPF) and CTD ILD (i.e., primary Sjogren syndrome, idiopathic inflammatory myopathies, etc), according to the Centres availability.\n\nConsecutive, unselected, DICOM files of chest HRCT of adult RA patients (regardless a previous diagnosis of ILD) will be evaluated by an expert thoracic radiologist blinded to patients' clinical history.\n\nHRCT patterns, presence of fibrosis and other lung abnormalities (cysts, nodules, pleural effusion, etc) will be recorded. In patients with RA ILD possible associations with demographic and clinical disease features will be also analysed (such as sex, disease duration, disease duration at ILD diagnosis, presence of ACPA, rheumatoid factor, ANA), inclusion of previous therapies.\n\nAfter 2 years, new HRCT and lung function tests will be collected for each enrolled patients when available, to evaluate possible changes of lung involvement over time.",[137,138,139,140],"Reumatoid Arthritis","Interstitial Lung Disease Due to Systemic Disease (Disorder)","Idiopathic Pulmonary Fibrosis (IPF)","Connective Tissue Disease (CTD)",[142,143,144,145,146],"rheumatoid arthritis","Interstitial lung disease","connective tissue disease","idiopathic pulmonary fibrosis","high resolution computed tomography","2025-09-11",{"date":149,"type":150},"2025-09-15","ACTUAL",{"date":152,"type":150},"2025-01-08",{"date":154,"type":133},"2035-01",{"name":5,"class":6},5]