[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639804":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":37,"locations":44,"responsibleParty":105,"collaborators":108,"id":114,"slug":115,"hasResults":116,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":116,"sex":122,"minAge":123,"maxAge":124,"enrollmentInfo":125,"targetDuration":24,"studyType":128,"phases":129,"briefSummary":131,"conditions":132,"keywords":135,"overallStatus":142,"whyStopped":24,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":152},{"fullName":5,"class":6},"Turku University Hospital","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Tonsillectomy","ACTIVE_COMPARATOR","TE will be performed by dissection in the peritonsillar plane. Parts of the upper and lateral palatal mucosal arches will be incised, and an extracapsular dissection for complete tonsil excision will be performed.\n\nThe surgical instrumentation (eg. cold steel, monopolar diathermy with a pen electrode, bipolar scissors, coblation technique or a microdebrider) is selected by the surgeon.",[13],"Procedure: Tonsillectomy",{"label":15,"type":10,"description":16,"interventionNames":17},"Tonsillotomy","TT will be performed by removing approximately 60 - 90% of the tonsillar tissue, leaving a rim of tonsillar tissue on the tonsillar fossae. The tonsil capsule will not be breached.\n\nThe surgical instrumentation (eg. cold steel, monopolar diathermy with a pen electrode, bipolar scissors, coblation technique or a microdebrider) is selected by the surgeon.",[18],"Procedure: Tonsillotomy",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","TE will be performed by dissection in the peritonsillar plane. Parts of the upper and lateral palatal mucosal arches will be incised, and an extracapsular dissection for complete tonsil excision will be performed.",[9],null,{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"TT will be performed by removing approximately 60 - 90% of the tonsillar tissue, leaving a rim of tonsillar tissue on the tonsillar fossae. The tonsil capsule will not be breached.",[15],[29,32,35],{"name":30,"affiliation":5,"role":31},"Jaakko M Piitulainen, MD, PhD","STUDY_DIRECTOR",{"name":33,"affiliation":5,"role":34},"Henrik Sjöblom, MD","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":5,"role":34},"Jenny Knubb, MD",[38,42],{"name":30,"role":39,"phone":40,"phoneExt":24,"email":41},"CONTACT","+35823130000","jaakko.piitulainen@utu.fi",{"name":33,"role":39,"phone":40,"phoneExt":24,"email":43},"henrik.sjoblom@varha.fi",[45,63,78,93],{"facility":46,"status":24,"city":47,"state":24,"zip":24,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Helsinki University Hospital","Helsinki","Finland","FI",{"type":51,"coordinates":52},"Point",[53,54],24.93545,60.16952,{"lat":54,"lon":53},[57,61],{"name":58,"role":39,"phone":59,"phoneExt":24,"email":60},"Johanna Ruohoalho, MD, PhD","+35894711","firstname.lastname@hus.fi",{"name":62,"role":39,"phone":24,"phoneExt":24,"email":24},"Vanhapiha Nelli, MD",{"facility":64,"status":24,"city":65,"state":24,"zip":24,"country":48,"countryCode":49,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Oulu University Hospital","Oulu",{"type":51,"coordinates":67},[68,69],25.46816,65.01236,{"lat":69,"lon":68},[72,76],{"name":73,"role":39,"phone":74,"phoneExt":24,"email":75},"Aleksi Laajala, MD","+35886699500","firstname.lastname@oulu.fi",{"name":77,"role":39,"phone":24,"phoneExt":24,"email":24},"Alakärppä Antti, MD, PhD",{"facility":79,"status":24,"city":80,"state":24,"zip":24,"country":48,"countryCode":49,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"Tampere University Hospital","Tampere",{"type":51,"coordinates":82},[83,84],23.78712,61.49911,{"lat":84,"lon":83},[87,91],{"name":88,"role":39,"phone":89,"phoneExt":24,"email":90},"Saara Markkanen, MD, PhD","+3583311611","firstname.lastname@pirha.fi",{"name":92,"role":39,"phone":24,"phoneExt":24,"email":24},"Saara Lesonen, MD",{"facility":5,"status":24,"city":94,"state":24,"zip":24,"country":48,"countryCode":49,"cosmosGeoPoint":95,"geoPoint":99,"contacts":100},"Turku",{"type":51,"coordinates":96},[97,98],22.26869,60.45148,{"lat":98,"lon":97},[101,104],{"name":102,"role":39,"phone":40,"phoneExt":24,"email":103},"Henrik M Sjöblom, MD","hmsjob@utu.fi",{"name":36,"role":39,"phone":40,"phoneExt":24,"email":24},{"type":34,"investigatorFullName":106,"investigatorTitle":107,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Jaakko Piitulainen","MD, PhD",[109,111,112],{"name":79,"class":110},"OTHER",{"name":64,"class":110},{"name":113,"class":110},"Helsinki University Central Hospital","100639804","randomized-clinical-trial-for-tonsil-surgery-in-adults-with-obstructive-sleep-apnea-and-enlarged-tonsils-100639804",false,"NCT07580170","Randomized Clinical Trial for Tonsil Surgery in Adults With Obstructive Sleep Apnea and Enlarged Tonsils","Multicenter, National, Randomized, Patient-Blinded, Parallel Group, Non-Inferiority Trial To Compare Tonsillotomy Versus Extracapsular Tonsillectomy in Adults With Obstructive Sleep Apnea and Tonsil Hypertrophy: The TONOS Trial.","TONOS","Inclusion Criteria:\n\n* BMI \\\u003C 35\n* Tonsil size 2 - 4\n* Otherwise healthy patient fit for tonsil surgery\n* Apnea-hypopnea index \\> 15\n* Obstructive sleep apnea symptoms\n\nExclusion Criteria:\n\n* Pathological hemostasis or use of anticoagulation\n* Craniofacial deformities\n* Neurological condition with muscular hypotonia\n* Other surgical treatment for OSA","ALL","18 Years","65 Years",{"count":126,"type":127},132,"ESTIMATED","INTERVENTIONAL",[130],"NA","The aim is to investigate whether the tissue-preserving tonsil surgery technique is as effective as complete tonsil removal in the treatment of obstructive sleep apnea. The primary outcome measure is the change in the apnea-hypopnea index (AHI) before surgery and at 4-6, 24, and 60 months after surgery.",[133,134],"Sleep Apnea, Obstructives","Tonsil Hypertrophy",[136,137,138,139,140,141],"sleep apnea","tonsillectomy","tonsillotomy","intracapsular tonsillectomy","adults","tonsil hypertrophy","NOT_YET_RECRUITING","2026-05-31",{"date":145,"type":146},"2026-06-03","ACTUAL",{"date":148,"type":127},"2026-10-01",{"date":150,"type":127},"2036-01-01",{"name":5,"class":6},4]