[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100578497":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":34,"centralContacts":38,"locations":44,"responsibleParty":69,"collaborators":29,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":29,"eligibilityCriteria":79,"healthyVolunteers":75,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":29,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":47,"whyStopped":29,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"First Hospital of China Medical University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Local Hyperthermia at 44℃","EXPERIMENTAL","As an experimental arm.",[13],"Device: Local Hyperthermia at 44℃",{"label":15,"type":10,"description":16,"interventionNames":17},"Local 3%H2O2 treatment","As an experimental arm",[18],"Drug: Hydrogen Peroxide 3 % Topical Solution",{"label":20,"type":10,"description":21,"interventionNames":22},"3%H2O2 for 1 hour, then local hyperthermia at 44℃ for 30 minutes","Undergo the hyperthermia treatment of the Local Hyperthermia Group and the dressing treatment of the 3% Hydrogen Peroxide Group. Apply the 3% hydrogen peroxide dressing 1 hour before each hyperthermia session.\n\nLocal Hyperthermia treats the target warts(largest and most severe warts), while medication addresses all warts.",[18,13],[24,30],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DRUG","Hydrogen Peroxide 3 % Topical Solution","Dressing: Like the Local Hyperthermia Group, use a cotton ball soaked in 3% hydrogen peroxide.\n\nIrradiation: For seven sessions in three weeks, use simulated infrared light (without heat) with the same frequency as the Local Hyperthermia Group.\n\nLocal Hyperthermia treats the target warts(largest and most severe warts), while medication addresses all warts.",[20,15],null,{"type":31,"name":9,"description":32,"armGroupLabels":33,"otherNames":29},"DEVICE","(Patent No: ZL 200820231952.4, Model: YY-WRY-V01, Liaoning Yanyang Medical Instrument Co., Ltd., China) An infrared hyperthermia device was used to apply local hyperthermia at 44°C to the largest wart. The device includes a heating source, an infrared temperature monitor, an adjusting arm, a control circuit for temperature stabilization, and a display. It uses a tungsten-halogen lamp (wavelength: 760-2300 nm, peak at 1200 nm) to maintain the temperature of a 0.5\\*0.5 cm skin area within ±0.1°C using a non-contact infrared feedback system.Hyperthermia: Conduct 44-degree Celsius, 30-minute sessions. Do it daily for the first 3 days, then 2 sessions every 7 days for 3 weeks, for a total of 7 sessions.\n\nDressing: Apply a cotton ball soaked in 0.9% saline to the warts, wrap it with plastic film for 1 hour, and do this once a day for 6 weeks. Local Hyperthermia treats the target warts(largest and most severe warts), while medication addresses all warts.",[20,9],[35],{"name":36,"affiliation":5,"role":37},"Xinghua Gao","STUDY_DIRECTOR",[39],{"name":40,"role":41,"phone":42,"phoneExt":29,"email":43},"Hao Guo","CONTACT","+86 13840365892","guohao27@126.com",[45,61],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Guo Hao","RECRUITING","Shenyang","Liaoning","110001","China","CN",{"type":54,"coordinates":55},"Point",[56,57],123.43278,41.79222,{"lat":57,"lon":56},[60],{"name":40,"role":41,"phone":42,"phoneExt":29,"email":43},{"facility":62,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":63,"geoPoint":65,"contacts":66},"infrared hyperthermia device (Patent No: ZL 200820231952.4, Model: YY-WRY-V01, Liaoning Yanyang Medical Instrument Co., Ltd., China)",{"type":54,"coordinates":64},[56,57],{"lat":57,"lon":56},[67],{"name":40,"role":41,"phone":68,"phoneExt":29,"email":43},"13840365892",{"type":70,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Gao Xinghua","Professor","100578497","randomized-controlled-clinical-trial-of-hyperthermia-and-hydrogen-peroxide-3-in-the-treatment-of-cutaneous-warts-100578497",false,"NCT06812065","Randomized Controlled Clinical Trial of Hyperthermia and Hydrogen Peroxide 3% in the Treatment of Cutaneous Warts","Rrandomized Controlled Clinical Trial Named Mild Local Hyperthermia and Hydrogen Peroxide Treat Multiple Warts by Targeting a Single Lesion.","Inclusion criteria: The participants were between 16 and 65 years of age, had a clinical diagnosis of viral warts (including common warts, plantar warts, or condyloma acuminatum), and could understand and sign informed consent.\n\nExclusion criteria: presented with clinically atypical warts; had immunocompromised status or a history of HIV infection; received HPV vaccination within the past 6 months; used immunomodulators, immunosuppressants, or systemic corticosteroids within defined timeframes (4 months and 1 month, respectively); underwent local therapies (e.g., laser, cryotherapy, retinoids) on or near warts within protocol-specified intervals; had a history of cutaneous malignancies or current precancerous lesions; exhibited active dermatologic\u002Fsystemic diseases (e.g., psoriasis, eczema) or skin conditions (e.g., sunburn) potentially increasing study risks; or were deemed ineligible by investigators for other medical or logistical reasons.","ALL","16 Years","65 Years",{"count":84,"type":85},300,"ESTIMATED","INTERVENTIONAL",[88],"NA","Hyperthermia treatment (hyperthermia) refers to treating diseases with temperature (39-45 ° C) beyond normal body temperature,. It has been reported that local warming at 44 ° C is able to effectively mobilize the body's immunity and clear HPV infected lesions, such as condyloma acuminatum and verruca vulgaris, etc.\n\nHydrogen peroxide (H2O2) is a commonly used disinfectant for skin debridement. It has been reported that high concentration of H2O2 (45% H2O2) is effective in the treatment of warts vulgaris, however, high concentration of H2O2 will cause more local pain, itching and burning sensation. 3% hydrogen peroxide is commonly used as skin debridement disinfectant.\n\nThe purpose of the study is to evaluate the efficacy and safety of 44℃ hyperthermia combined with 3% hydrogen peroxide in treating verruca virus.",[91],"Warts",[93,91,94],"hyperthermia","Hydrogen Peroxide","2025-02-02",{"date":97,"type":98},"2025-02-06","ACTUAL",{"date":100,"type":98},"2022-12-07",{"date":102,"type":85},"2026-12-31",{"name":5,"class":6},2]