[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603834":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":37,"collaborators":26,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":41,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":26,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":65,"whyStopped":26,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":26},{"fullName":5,"class":6},"RenJi Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Bupivacaine HCL Group","ACTIVE_COMPARATOR","Erector spinae plane block with normal saline 10ml and bupivacaine HCL 0.5% 20ml",[13],"Procedure: Erector spinae plane block with bupivacaine HCL",{"label":15,"type":16,"description":17,"interventionNames":18},"Liposomal Bupivacaine Group","EXPERIMENTAL","Erector spinae plane block with normal saline 10ml and liposomal bupivacaine 1.33% 20ml",[19],"Procedure: Erector spinae plane block with liposomal bupivacaine",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Erector spinae plane block with liposomal bupivacaine","In the anesthesia induction suite, the anesthesiologist administers an ultrasound-guided erector spinae plane (ESP) block under local anesthesia prior to the induction of general anesthesia. The procedure involves the sequential injection of 10 mL of normal saline, followed by the administration of 20 mL of 1.33% liposomal bupivacaine.",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Erector spinae plane block with bupivacaine HCL","In the anesthesia induction suite, the anesthesiologist administers an ultrasound-guided erector spinae plane (ESP) block under local anesthesia prior to the induction of general anesthesia. The procedure involves the sequential injection of 10 mL of normal saline, followed by the administration of 20 mL of 0.5% bupivacaine HCL.",[9],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"zhisheng Lu","CONTACT","+8618916951095","luzhisheng@renji.com",{"type":38,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100603834","randomized-trial-of-erector-spinae-plane-block-using-liposomal-bupivacaine-versus-bupivacaine-hydrochloride-on-quality-of-recovery-for-video-assisted-thoracic-surgery-100603834",false,"NCT07141667","Randomized Trial of Erector Spinae Plane Block Using Liposomal Bupivacaine Versus Bupivacaine Hydrochloride on Quality of Recovery for Video-assisted Thoracic Surgery","Erector Spinae Plane Block Using Liposomal Bupivacaine Versus Bupivacaine Hydrochloride for Video-assisted Thoracic Surgery:Comparing Local Anesthetics on Quality of Recovery and Pain Score:A Randomised,Single-blind,Clinical Trial","LB-ESPB","Inclusion Criteria:\n\n* 18-75 yr of age\n* ASA physical status 1 to 3\n* Undergoing unilateral lung VATS under general anesthesia\n* Obtaining informed consent from patients or legal representative\n\nExclusion Criteria:\n\n* Unexpected convention of VATS to open thoracotomy,or unexpected post-operative admission to ICU for continued ventilation\n* Unable to understand the Quality of Recovery-15 (QoR-15) and Numerical Rating Scale(NRS)\n* Allergy to or contraindications for amide local anesthetics,opioids,or NSAIDs\n* Long-term treatment with opioids or corticosteroids (\\>2 weeks)\n* Drug use or substance abuse within the past 2 years\n* Consuming more than 3 standard drinks per day (10g of alcohol,equivalent to 50g of Chinese high-alcohol liquor)\n* Pre existing dementia that may interfere with perioperative assessment\n* Contraindications for nerve block,including infection or tumor at the puncture site,definitively diagnosed diabetic peripheral neuropathy\n* Suffering from severe hepatic insufficiency (Child-Pugh C),or severe renal insufficiency with dialysis,or severe heart failure (METS\\\u003C4)\n* Pregnant or lactating women\n* Previous thoracic surgeries (such an thoracic surgery or breast surgery),or preoperatively pathological pain conditions (e.g.,metastatic tumors,herpes zoster,etc)","ALL","18 Years","75 Years",{"count":51,"type":52},80,"ESTIMATED","INTERVENTIONAL",[55],"NA","Video-assisted thoracoscopic surgery (VATS) has emerged as the standard surgical modality for pulmonary tumor. Compared with open thoracotomy, VATS is associated with reduced surgical trauma, attenuated postoperative pain, and a lower incidence of postoperative pulmonary complications. Nevertheless, 27-63% of VATS patients still develop moderate to severe postoperative pain, with the incidence of chronic postsurgical pain (CPSP) remaining at 25-44%.\n\nRegional analgesic techniques constitute a pivotal component of enhanced recovery after surgery (ERAS) protocols in thoracic surgery. Thoracic epidural analgesia (TEA) and paravertebral block (PVB) have been regarded as the gold-standard regional analgesic modalities for open thoracotomy. Accumulating evidence indicates that erector spinae plane block (ESPB) achieves postoperative analgesic efficacy comparable to that of PVB. In contrast to TEA, both PVB and ESPB are associated with a lower risk of complications such as hypotension, urinary retention, and epidural hematoma.\n\nA recent randomized controlled trial comparing continuous ESPB and continuous PVB demonstrated that continuous ESPB improves the quality of postoperative recovery in VATS patients. Previous studies have also confirmed that single-injection ESPB provides superior recovery quality and analgesic efficacy compared with single-injection PVB in VATS patients. However, single-dose nerve block only exert effects for 8-12 hours, while continuous nerve blocks may increase the risk of infection and compromise patient comfort. Moderate to severe postoperative pain in VATS patients predominantly occurs within the first 48 hours postoperatively, with the most intense pain typically observed on the first postoperative day. Therefore, there is an urgent need to explore analgesic techniques with prolonged duration and fewer complications for application in VATS.\n\nLiposomal bupivacaine, a novel extended-release local anesthetic approved by the FDA for clinical use, can prolong the duration of local anesthesia to 72 hours. Its clinical efficacy in procedures such as brachial plexus block has been validated. However, the application of liposomal bupivacaine in erector spinae plane block for VATS, and its impact on the quality of postoperative recovery, remains unreported.This study will test the hypothesis that erector spinae plane block with liposomal bupivacaine for VATS can enhance patients' quality of recovery-15 score (QoR-15) at 48 h.",[58,59],"Regional Anesthesia Morbidity","Pain, Postoperative",[61,62,63,64],"quality of recovery","erector spinae plane block","liposomal bupivacaine","video-assisted thoracic surgery","NOT_YET_RECRUITING","2025-08-24",{"date":68,"type":69},"2025-08-26","ACTUAL",{"date":71,"type":52},"2025-08",{"date":73,"type":52},"2028-03",{"name":5,"class":6}]