[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641125":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":32,"centralContacts":36,"locations":23,"responsibleParty":46,"collaborators":23,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":51,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":23,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":74,"whyStopped":23,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":23},{"fullName":5,"class":6},"Shanghai Jiao Tong University Affiliated Sixth People's Hospital","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"High-dose RL-IPostC","EXPERIMENTAL","Postconditioning intervention with 2 minutes of inflation \u002F 2 minutes of deflation, for 4 cycles.",[13],"Procedure: High-dose RL-IPostC",{"label":15,"type":10,"description":16,"interventionNames":17},"Low-dose RL-IPostC","Postconditioning intervention with 15 seconds of inflation \u002F 15 seconds of deflation, for 5 cycles.",[18],"Procedure: Low-dose RL-IPostC",{"label":20,"type":21,"description":22,"interventionNames":23},"Control","NO_INTERVENTION","No postconditioning intervention after successful thrombectomy.",null,[25,29],{"type":26,"name":9,"description":27,"armGroupLabels":28,"otherNames":23},"PROCEDURE","For acute anterior circulation with large core ischemic stroke patients who achieve successful vessel recanalization (mTICI 2b\u002F3) after thrombectomy, within 5 minutes, the balloon guide catheter (BGC) is positioned in the straight segment of the ipsilateral internal carotid artery at the C1-C2 level, avoiding the carotid sinus. Repetitive balloon inflations (2 minutes) to block blood flow followed by deflations (2 minutes) to restore blood flow (for 4 cycles) are performed. After the first BGC inflation, confirmation of antegrade flow blockade in the internal carotid artery is required. At the end of the cycle, angiography is performed to confirm vessel patency.",[9],{"type":26,"name":15,"description":30,"armGroupLabels":31,"otherNames":23},"For acute anterior circulation with large core ischemic stroke patients who achieve successful vessel recanalization (mTICI 2b\u002F3) after thrombectomy, within 5 minutes, the balloon guide catheter (BGC) is positioned in the straight segment of the ipsilateral internal carotid artery at the C1-C2 level, avoiding the carotid sinus. Repetitive balloon inflations (15 seconds) to block blood flow followed by deflations (15 seconds) to restore blood flow (for 5 cycles) are performed. After the first BGC inflation, confirmation of antegrade flow blockade in the internal carotid artery is required. At the end of the cycle, angiography is performed to confirm vessel patency.",[15],[33],{"name":34,"affiliation":5,"role":35},"Yueqi Zhu, MD","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":23,"email":41},"Yining Tao, MD","CONTACT","0086-021-64844183","yiningtao1001@163.com",{"name":43,"role":39,"phone":44,"phoneExt":23,"email":45},"Jiangshan Deng, MD","0086-021-64507181","johnson120@126.com",{"type":35,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Yueqi Zhu","Head of Interventional Radiology Department","100641125","rapid-local-ischemic-postconditioning-on-stroke-after-thrombectomy-100641125",false,"NCT07598799","Rapid Local Ischemic Postconditioning on Stroke After Thrombectomy","Rapid Local Ischemic Postconditioning Following Successful Recanalization After Endovascular Thrombectomy in Large Ischemic Core Stroke","RAPIDIMPROVE","Inclusion Criteria:\n\n1. Age 18-85 years\n2. Diagnosis of acute ischemic stroke\n3. Pre-stroke mRS 0-1\n4. Baseline NIHSS score ≥ 6\n5. Time from symptom onset to start of endovascular procedure (puncture) \\\u003C 24 hours; onset time defined as \"last known well\" time\n6. Imaging criteria: ASPECTS 3-5 on CT, or ASPECTS \\> 5 with acute ischemic core volume (defined as rCBF \\\u003C 30% or ADC \\\u003C 620) ≥ 50 mL\n7. Occlusion of the intracranial segment of the internal carotid artery or the middle cerebral artery (M1\u002FM2), confirmed as the symptomatic culprit vessel\n8. After thrombectomy, the culprit vessel is considered to be occluded by an embolus, and successful recanalization (mTICI 2b\u002F3, i.e., ≥ 50% perfusion) is achieved\n9. Written informed consent signed by the patient or a legal representative\n\nExclusion Criteria:\n\n1. Presence of stenosis (≥ 50%) in the ipsilateral middle cerebral artery, internal carotid artery, or common carotid artery proximal to the occlusion site\n2. Multiple emboli across different circulations (simultaneous anterior and posterior circulation emboli, or simultaneous left and right anterior circulation emboli)\n3. Evidence on CT of extensive cerebral edema, midline shift, significant mass effect, or signs of brain herniation\n4. Presence of a life-threatening disease with a prognosis \\\u003C 6 months, making 3-month follow-up impossible\n5. Severe psychiatric disorder or heart failure\n6. Concurrent participation in another clinical drug or device study\n7. Any other condition that, in the investigator's judgment, makes the subject unsuitable for this study","ALL","18 Years","85 Years",{"count":61,"type":62},448,"ESTIMATED","INTERVENTIONAL",[65],"NA","The main goal of this study is to find out if a new, quick \"brain rescue\" procedure can help people recover better from a severe stroke caused by a large vessel occlusion.\n\nWhen someone has this type of stroke, doctors often perform a procedure called an endovascular thrombectomy (EVT). In EVT, they thread a thin tube through a blood vessel up to the brain to remove the clot and restore blood flow. This is a highly effective treatment.\n\nHowever, for some patients, suddenly restoring blood flow can cause additional, unexpected injury to the brain. This is called \"reperfusion injury.\" This study tests a technique called rapid local ischemic postconditioning (RL-IPostC) that might prevent this extra damage. It's a very simple additional step performed immediately after the clot is successfully removed.\n\nThe doctor would briefly inflate and deflate a tiny balloon inside the proximal brain artery after recanalization, creating very short, controlled \"pauses\" in blood flow. This is believed to give brain cells a gentler \"wake-up\" call, helping them tolerate the return of oxygen-rich blood.\n\nThe study will test two different \"doses\" of this procedure (meaning different numbers of inflation\u002Fdeflation cycles) against the standard care (no additional procedure).\n\nPhase IIb (the first part): Which dose of RL-IPostC (high or low) is more promising for reducing early brain swelling (measured by whether the brain's midline has shifted less than 3 mm on a 24-hour scan)? Phase III (the main part): Using the best dose from Phase IIb, does RL-IPostC improve a patient's functional recovery three months later, specifically enabling them to walk and manage daily activities without help? A total of 288 participants who have had a large-vessel occlusion stroke and successful clot removal will be enrolled. If early results look promising but not quite conclusive, the study can increase the total number of participants up to 448 to get a clearer answer.\n\nIf successful, this study could identify a simple, low-cost add-on procedure to a standard stroke treatment that improves long-term recovery and quality of life for thousands of stroke patients. It's a potential new tool to protect the brain after blood flow is restored. This is a carefully designed study testing a gentle \"on\u002Foff\" blood flow technique right after clot removal, to see if it can reduce brain injury and help people walk and live more independently after a severe stroke.",[68],"Acute Ischemic Stroke",[70,71,72,73],"Ischemic postconditioning","Endovascular thrombectomy","Neuroprotection","Ischemic reperfusion injury","NOT_YET_RECRUITING","2026-06-03",{"date":77,"type":78},"2026-06-04","ACTUAL",{"date":80,"type":62},"2026-07-01",{"date":82,"type":62},"2029-05-30",{"name":5,"class":6}]