[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100481074":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":17,"responsibleParty":250,"collaborators":252,"id":256,"slug":257,"hasResults":258,"nctId":259,"briefTitle":260,"officialTitle":260,"acronym":261,"eligibilityCriteria":262,"healthyVolunteers":258,"sex":263,"minAge":7,"maxAge":7,"enrollmentInfo":264,"targetDuration":7,"studyType":267,"phases":7,"briefSummary":268,"conditions":269,"keywords":277,"overallStatus":20,"whyStopped":7,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":289},{"fullName":5,"class":6},"University of South Florida","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Jeffrey Krischer, PhD","STUDY_CHAIR",[13],{"name":10,"role":14,"phone":15,"phoneExt":7,"email":16},"CONTACT","813-396-9501","contact@atypicaldiabetesnetwork.org",[18,40,59,76,93,110,127,148,165,180,197,214,233],{"facility":19,"status":20,"city":21,"state":22,"zip":23,"country":24,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"University of Colorado- Denver","RECRUITING","Aurora","Colorado","80045","United States","US",{"type":27,"coordinates":28},"Point",[29,30],-104.83192,39.72943,{"lat":30,"lon":29},[33,37],{"name":34,"role":14,"phone":35,"phoneExt":7,"email":36},"Marjan Rezaei","303-724-1290","marjan.rezaei@cuanschutz.edu",{"name":38,"role":39,"phone":7,"phoneExt":7,"email":7},"Neda Rasouli, MD","PRINCIPAL_INVESTIGATOR",{"facility":41,"status":20,"city":42,"state":43,"zip":44,"country":24,"countryCode":25,"cosmosGeoPoint":45,"geoPoint":49,"contacts":50},"University of Chicago","Chicago","Illinois","60637",{"type":27,"coordinates":46},[47,48],-87.65005,41.85003,{"lat":48,"lon":47},[51,55,57],{"name":52,"role":14,"phone":53,"phoneExt":7,"email":54},"Lisa Letourneau","773-702-0829","radiant@uchicago.edu",{"name":56,"role":39,"phone":7,"phoneExt":7,"email":7},"Lou Philipson, MD, PhD",{"name":58,"role":39,"phone":7,"phoneExt":7,"email":7},"Siri Greeley, MD, PhD",{"facility":60,"status":20,"city":61,"state":62,"zip":63,"country":24,"countryCode":25,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"Indiana University","Indianapolis","Indiana","46202",{"type":27,"coordinates":65},[66,67],-86.15804,39.76838,{"lat":67,"lon":66},[70,74],{"name":71,"role":14,"phone":72,"phoneExt":7,"email":73},"Sarah Fischer","317-278-7042","hollowas@iu.edu",{"name":75,"role":39,"phone":7,"phoneExt":7,"email":7},"Carmella Evans-Molina, MD, PhD",{"facility":77,"status":20,"city":78,"state":79,"zip":80,"country":24,"countryCode":25,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"University of Maryland","Baltimore","Maryland","21201",{"type":27,"coordinates":82},[83,84],-76.61219,39.29038,{"lat":84,"lon":83},[87,91],{"name":88,"role":14,"phone":89,"phoneExt":7,"email":90},"Cindi Young","410-979-4322","cyoung2@som.umaryland.edu",{"name":92,"role":39,"phone":7,"phoneExt":7,"email":7},"Toni Pollin, PhD, MS",{"facility":94,"status":20,"city":95,"state":96,"zip":97,"country":24,"countryCode":25,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"Massachusetts General Hospital (MGH)","Boston","Massachusetts","02114",{"type":27,"coordinates":99},[100,101],-71.05977,42.35843,{"lat":101,"lon":100},[104,108],{"name":105,"role":14,"phone":106,"phoneExt":7,"email":107},"Julia Douvas","617-724-3954","MGHRADIANTStudy@partners.org",{"name":109,"role":39,"phone":7,"phoneExt":7,"email":7},"Sara Cromer, MD",{"facility":111,"status":20,"city":112,"state":113,"zip":114,"country":24,"countryCode":25,"cosmosGeoPoint":115,"geoPoint":119,"contacts":120},"University of Michigan","Ann Arbor","Michigan","48109",{"type":27,"coordinates":116},[117,118],-83.74088,42.27756,{"lat":118,"lon":117},[121,125],{"name":122,"role":14,"phone":123,"phoneExt":7,"email":124},"Adam Neidert","734-615-0539","aneidert@med.umich.edu",{"name":126,"role":39,"phone":7,"phoneExt":7,"email":7},"Elif Oral, MD",{"facility":128,"status":20,"city":129,"state":130,"zip":131,"country":24,"countryCode":25,"cosmosGeoPoint":132,"geoPoint":136,"contacts":137},"Washington University in St. Louis","St Louis","Missouri","63110",{"type":27,"coordinates":133},[134,135],-90.19789,38.62727,{"lat":135,"lon":134},[138,142,146],{"name":139,"role":14,"phone":140,"phoneExt":7,"email":141},"Stacy Hurst","314-747-3294","shurst@wustl.edu",{"name":143,"role":14,"phone":144,"phoneExt":7,"email":145},"Brittany Zsijack","314-747-8251","bzwijack@wustl.edu",{"name":147,"role":39,"phone":7,"phoneExt":7,"email":7},"Fumihiko Urano, MD, PhD",{"facility":149,"status":20,"city":150,"state":151,"zip":152,"country":24,"countryCode":25,"cosmosGeoPoint":153,"geoPoint":157,"contacts":158},"SUNY Downstate Health Sciences University","Brooklyn","New York","11203",{"type":27,"coordinates":154},[155,156],-73.94958,40.6501,{"lat":156,"lon":155},[159,163],{"name":160,"role":14,"phone":161,"phoneExt":7,"email":162},"Necole Brown","718-270-4693","necole.brown01@downstate.edu",{"name":164,"role":39,"phone":7,"phoneExt":7,"email":7},"Mary Ann Banerji, MD",{"facility":166,"status":20,"city":151,"state":151,"zip":167,"country":24,"countryCode":25,"cosmosGeoPoint":168,"geoPoint":172,"contacts":173},"Columbia University","10032",{"type":27,"coordinates":169},[170,171],-74.00597,40.71427,{"lat":171,"lon":170},[174,178],{"name":175,"role":14,"phone":176,"phoneExt":7,"email":177},"Kaisha Mofford","212-851-5512","berrietrials@cumc.columbia.edu",{"name":179,"role":39,"phone":7,"phoneExt":7,"email":7},"Robin Goland, MD",{"facility":181,"status":20,"city":182,"state":183,"zip":184,"country":24,"countryCode":25,"cosmosGeoPoint":185,"geoPoint":189,"contacts":190},"University of North Carolina at Chapel Hill","Chapel Hill","North Carolina","27514",{"type":27,"coordinates":186},[187,188],-79.05584,35.9132,{"lat":188,"lon":187},[191,195],{"name":192,"role":14,"phone":193,"phoneExt":7,"email":194},"Rachel Unger","984-974-3011","RADIANT@med.unc.edu",{"name":196,"role":39,"phone":7,"phoneExt":7,"email":7},"John Buse, MD, PhD",{"facility":198,"status":20,"city":199,"state":200,"zip":201,"country":24,"countryCode":25,"cosmosGeoPoint":202,"geoPoint":206,"contacts":207},"Vanderbilt University","Nashville","Tennessee","37232",{"type":27,"coordinates":203},[204,205],-86.78444,36.16589,{"lat":205,"lon":204},[208,212],{"name":209,"role":14,"phone":210,"phoneExt":7,"email":211},"Norma Edwards","615-403-8937","radiant@vumc.org",{"name":213,"role":39,"phone":7,"phoneExt":7,"email":7},"Kevin Niswender, MD, PhD",{"facility":215,"status":20,"city":216,"state":217,"zip":218,"country":24,"countryCode":25,"cosmosGeoPoint":219,"geoPoint":223,"contacts":224},"Baylor College of Medicine","Houston","Texas","77030",{"type":27,"coordinates":220},[221,222],-95.36327,29.76328,{"lat":222,"lon":221},[225,229,231],{"name":226,"role":14,"phone":227,"phoneExt":7,"email":228},"Molly Wahlquist","791-798-5757","radiantstudy@bcm.edu",{"name":230,"role":39,"phone":7,"phoneExt":7,"email":7},"Ashok Balasubramanyam, MD",{"name":232,"role":39,"phone":7,"phoneExt":7,"email":7},"Maria Redondo, MD, PhD, MPH",{"facility":234,"status":20,"city":235,"state":236,"zip":237,"country":24,"countryCode":25,"cosmosGeoPoint":238,"geoPoint":242,"contacts":243},"University of Washington","Seattle","Washington","98109",{"type":27,"coordinates":239},[240,241],-122.33207,47.60621,{"lat":241,"lon":240},[244,248],{"name":245,"role":14,"phone":246,"phoneExt":7,"email":247},"Dori Khakpour","206-616-1354","dorik@uw.edu",{"name":249,"role":39,"phone":7,"phoneExt":7,"email":7},"Irl B Hirsch, MD",{"type":251,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[253],{"name":254,"class":255},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100481074","rare-and-atypical-diabetes-network-100481074",false,"NCT05544266","Rare and Atypical Diabetes Network","RADIANT","Inclusion Criteria:\n\nThe following criteria or phenotypes will be considered for suspecting \"atypical\" participants:\n\n* Type 2 diabetes diagnosed at a time when the individual was prepubertal or non-obese\n* Mendelian pattern, especially with early onset (\\\u003C18 years old)\n* Syndromic (multiple systems involved)\n* Lipodystrophic\n* Extremes of BMI\n* \"Mitochondrial\" characteristics (e.g., myopathy, hearing deficits)\n* Non-progressive\n* Rapidly progressive (\"fulminant\")\n* Low insulin requirements (\\\u003C0.5 u\u002Fkg\u002Fday)\n* Cyclical hyperglycemia with periods of remission\n* Lean persons with polycystic ovarian syndrome (PCOS)\n* History of gestational diabetes (GDM) when lean\n* Lean insulin-resistant persons\n* If islet autoantibodies and beta-cell function parameters have been measured (where \"A\" = islet cell autoantibodies, \"B\" = beta-cell function):\n\noA-B- (i.e., lacking islet autoimmunity makers and lacking beta cell function) oA-B+ with unprovoked DKA at initial presentation (i.e., lacking islet autoimmune markers, with preserved beta-cell function, but presenting with unprovoked DKA) oA-B+ of very young onset (pre-pubertal) (i.e., lacking islet autoimmune markers, with preserved beta-cell function, but very early onset T2D-like phenotype)\n\nExclusion Criteria:\n\n* Those with high likelihood of typical type 1, typical type 2, known monogenic, or other known secondary forms of diabetes\n* Refusal of consent for genetic testing\n* Islet autoantibody positive (participants who are islet autoantibody positive but present with additional atypical features i.e. syndromic, strong linear family history of diabetes may not be excluded)\n* Women who are currently pregnant","ALL",{"count":265,"type":266},2000,"ESTIMATED","OBSERVATIONAL","RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of atypical diabetes.\n\nThe objective of this study is to define new forms of diabetes and the unique mechanisms underlying these forms of atypical diabetes. The specific aims are to:\n\n1. Identify and enroll individuals and families with undiagnosed rare and atypical forms of diabetes.\n2. Determine the etiologic basis of the metabolic disorder among individuals and families with novel forms of rare and atypical diabetes.\n3. Understand the pathophysiology of individuals and families with novel forms of rare and atypical forms of diabetes.",[270,271,272,273,274,275,276],"Diabetes Mellitus","Diabetes Mellitus Progression","Glucose Intolerance","Glucose Metabolism Disorders","Metabolic Disease","Endocrine; Complications","Endocrine System Diseases",[261,278,279,272],"Atypical Diabetes","Rare Diabetes","2025-08-11",{"date":282,"type":283},"2025-08-14","ACTUAL",{"date":285,"type":283},"2020-09-30",{"date":287,"type":266},"2030-09",{"name":5,"class":6},13]