[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053465":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":51,"collaborators":18,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":18,"eligibilityCriteria":59,"healthyVolunteers":56,"sex":60,"minAge":61,"maxAge":18,"enrollmentInfo":62,"targetDuration":18,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":75,"whyStopped":18,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Sylhet M.A.G.Osmani Medical College","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Levofloxacin Infiltration Group","EXPERIMENTAL","Patients undergoing emergency laparotomy for contaminated or dirty\u002Finfected abdominal conditions will receive subcutaneous infiltration of levofloxacin solution (5 mg\u002FmL) along both wound edges immediately before skin closure, in addition to standard surgical and perioperative management.",[13],"Drug: Levofloxacin",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Care Group","NO_INTERVENTION","Patients undergoing emergency laparotomy for contaminated or dirty\u002Finfected abdominal conditions will receive standard surgical management and perioperative care alone, without subcutaneous levofloxacin infiltration.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DRUG","Levofloxacin","Levofloxacin solution (5 mg\u002FmL) infiltrated subcutaneously along the wound edges at a dose calculated according to wound surface area (approximately 1 mL\u002Fcm²), not exceeding the standard maximum systemic dose, administered immediately prior to skin closure.",[9],[26],{"name":27,"affiliation":28,"role":29},"Pranto Chakroborty, MBBS","Sylhet MAG Osmani Medical College Hospital","PRINCIPAL_INVESTIGATOR",[31,35],{"name":27,"role":32,"phone":33,"phoneExt":18,"email":34},"CONTACT","+8801735303838","pranto.cby@gmail.com",{"name":28,"role":32,"phone":18,"phoneExt":18,"email":34},[37],{"facility":38,"status":18,"city":39,"state":18,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Sylhet MAG Osmani Medical College","Sylhet","3100","Bangladesh","BD",{"type":44,"coordinates":45},"Point",[46,47],91.87198,24.89904,{"lat":47,"lon":46},[50],{"name":27,"role":32,"phone":33,"phoneExt":18,"email":34},{"type":29,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Pranto Chakroborty","FCPS Part-II Trainee (Neurosurgery)","100053465","rationale-of-subcutaneous-levofloxacin-infiltration-as-an-adjunct-for-surgical-site-infection-prevention-in-emergency-laparotomy-100053465",false,"NCT07696819","Rationale of Subcutaneous Levofloxacin Infiltration as an Adjunct for Surgical Site Infection Prevention in Emergency Laparotomy","Inclusion Criteria:\n\n* Patients aged 18 years and above\n* Patients undergoing emergency laparotomy for contaminated surgical pathology\n* Patients undergoing emergency laparotomy for dirty\u002Finfected surgical pathology\n\nExclusion Criteria:\n\n* Patients with known hypersensitivity to levofloxacin or other fluoroquinolones\n* Pregnant women or lactating mothers\n* Patients with pre-existing severe renal impairment\n* Patients with pre-existing skin infection at the incision site\n* Patients requiring re-laparotomy within 48 hours","ALL","18 Years",{"count":63,"type":64},90,"ESTIMATED","INTERVENTIONAL",[67],"NA","Surgical site infection (SSI) remains a major cause of postoperative morbidity following emergency laparotomy, particularly in contaminated and dirty\u002Finfected abdominal conditions. Systemic antibiotic prophylaxis alone often fails to achieve adequate local tissue concentrations at the incision site due to impaired perfusion, contributing to persistently high SSI rates in this population.\n\nThis trial evaluates subcutaneous infiltration of levofloxacin, a broad-spectrum fluoroquinolone with favorable tissue penetration, administered along the wound edges immediately prior to skin closure, as an adjunct to standard surgical and antibiotic management.\n\nThis study is investigator-initiated and will be conducted as a single-center trial within the Department of Surgery, Sylhet MAG Osmani Medical College Hospital.",[70],"Surgical Site Infection (SSI)",[72,73,74,22],"Surgical Site Infection","Emergency Laparotomy","Subcutaneous Infiltration","NOT_YET_RECRUITING","2026-07-10",{"date":78,"type":79},"2026-07-13","ACTUAL",{"date":81,"type":64},"2026-08-01",{"date":83,"type":64},"2026-10-31",{"name":5,"class":6},1]