[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100479596":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":48,"centralContacts":52,"locations":61,"responsibleParty":92,"collaborators":95,"id":99,"slug":100,"hasResults":101,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":43,"eligibilityCriteria":105,"healthyVolunteers":101,"sex":106,"minAge":107,"maxAge":43,"enrollmentInfo":108,"targetDuration":43,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":119,"overallStatus":75,"whyStopped":43,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":131},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8,14,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Group","PLACEBO_COMPARATOR","Subjects assigned to Contro Group will not receive VT or HMB. They will receive daily protein supplement for 6 months.",[13],"Dietary Supplement: Protein supplement",{"label":15,"type":16,"description":17,"interventionNames":18},"HMB only Group","ACTIVE_COMPARATOR","Subjects assigned to HMB only Group will receive HMB supplement at 3g\u002Fday and daily protein supplement for 6 months.",[19,13],"Dietary Supplement: β-hydroxy β-methylbutyrate (HMB) supplement",{"label":21,"type":16,"description":22,"interventionNames":23},"VT only Group","Subjects assigned to VT only Group will receive VT (0.3g, 35Hz, at least 3 times\u002Fweek) and daily protein supplement for 6 months",[24,13],"Device: Low-magnitude High-frequency Vibration",{"label":26,"type":27,"description":28,"interventionNames":29},"HMB + VT Group","EXPERIMENTAL","Subjects assigned to HMB + VT Group will receive HMB supplement at 3g\u002Fday, VT at least 3 times\u002Fweek and daily protein supplement for 6 months.",[24,19,13],[31,38,44],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DEVICE","Low-magnitude High-frequency Vibration","0.3g, 35Hz, 20mins\u002Fday, at least 3 times\u002Fweek",[26,21],[37],"Vibration Treatment",{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"DIETARY_SUPPLEMENT","β-hydroxy β-methylbutyrate (HMB) supplement","Oral nutritional HMB supplement at 3g\u002Fday",[26,15],null,{"type":39,"name":45,"description":46,"armGroupLabels":47,"otherNames":43},"Protein supplement","Daily protein supplement intake",[9,26,15,21],[49],{"name":50,"affiliation":5,"role":51},"Wing Hoi Cheung, PhD","PRINCIPAL_INVESTIGATOR",[53,57],{"name":50,"role":54,"phone":55,"phoneExt":43,"email":56},"CONTACT","35052715","louischeung@cuhk.edu.hk",{"name":58,"role":54,"phone":59,"phoneExt":43,"email":60},"Meng Chen Michelle Li, PhD","35053312","michellemcli@cuhk.edu.hk",[62,73,85],{"facility":63,"status":64,"city":65,"state":43,"zip":43,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":43},"Evangelical Luthera Church Social Service - Hong Kong","ACTIVE_NOT_RECRUITING","Hong Kong","HK",{"type":68,"coordinates":69},"Point",[70,71],114.17469,22.27832,{"lat":71,"lon":70},{"facility":74,"status":75,"city":65,"state":43,"zip":43,"country":65,"countryCode":66,"cosmosGeoPoint":76,"geoPoint":78,"contacts":79},"The Chinese University of Hong Kong Jockey Club Centre for Osteoporosis Care and Control","RECRUITING",{"type":68,"coordinates":77},[70,71],{"lat":71,"lon":70},[80,83],{"name":81,"role":54,"phone":43,"phoneExt":43,"email":82},"Zhihui Lu, PhD","anjolu@cuhk.edu.hk",{"name":84,"role":51,"phone":43,"phoneExt":43,"email":43},"Timothy Chi Yui Kwok, PhD",{"facility":86,"status":75,"city":65,"state":43,"zip":43,"country":65,"countryCode":66,"cosmosGeoPoint":87,"geoPoint":89,"contacts":90},"The Chinese University of Hong Kong, Department of Orthopaedics and Traumatology, 1\u002FF Li Ka Shing Outpatient Clinic (North), PWH",{"type":68,"coordinates":88},[70,71],{"lat":71,"lon":70},[91],{"name":58,"role":54,"phone":43,"phoneExt":43,"email":43},{"type":51,"investigatorFullName":93,"investigatorTitle":94,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"Professor CHEUNG Wing hoi, Louis","Professor",[96],{"name":97,"class":98},"Abbott","INDUSTRY","100479596","rct-of-combination-effect-of-vibration-treatment-and-hmb-supplementation-on-myosteatosis-and-nmj-degeneration-100479596",false,"NCT05525039","RCT of Combination Effect of Vibration Treatment and HMB Supplementation on Myosteatosis and NMJ Degeneration","Dissecting the Therapeutic Mechanism of an Effective Combination Treatment Targeting Neuromuscular Junction Dengeneration and Myosteatosis to Combat Sarcopenia","Inclusion Criteria:\n\n* Subjects aged 60 years or above\n* Subjects failed in AWGS algorithm\n\n  1. skeletal muscle mass by BIA (male at \\\u003C7.0 kg\u002Fm\\^2, female at \\\u003C5.7 kg\u002Fm\\^2), and\n  2. handgrip strength (male at \\\u003C28 kg, female at \\\u003C18kg), and\u002For\n  3. gait speed test (\\>1m\u002Fs)\n\nExclusion Criteria:\n\n* Subjects with pathological bone diseases\n* Subjects with chronic inflammatory condition (e.g. rheumatoid arthritis)\n* Subjects with neurological problems\n* Subjects receiving regular exercise\n* Subjecs who are chair-\u002Fbed- bound\n* Subjects with malignancy\n* Subjects with cardiovascular concern such as with pace-maker in-situ\n* Subjects with acute fractures or severe osteoarthritis","ALL","60 Years",{"count":109,"type":110},200,"ESTIMATED","INTERVENTIONAL",[113],"NA","The investigators' pre-clinical study confirms the positive effects of combined treatment (VT + HMB) on reducing fat-to-lean tissue ratio, intramuscular fat infiltration and increasing muscle strength in sarcopenia animal model. The results showed that fat mass could be decreased by \\~32%, while histology Oil Red O staining indicated a decrease of fat by almost 60%; in contrast, lean muscle mass increased by \\~14%. On muscle strength, combined treatment increased twitch force, tetanic force and grip strength by \\~30-66%. These in vivo results are very encouraging and the investigators should explore its potential in clinical translation. As VT and HMB supplement have been commercially available and their compliance rates are satisfactory, they can be translated to clinical application easily. The investigators' next step is to confirm its clinical efficacy, so that sarcopenia becomes a new indication of VT and HMB. The hypothesis is that combined treatment of VT and HMB can retard the progression of sarcopenia in human, in terms of muscle mass, muscle strength and performance.",[116,117,118],"Sarcopenia","Connective Tissue Diseases in Old Age","Musculoskeletal Abnormalities",[116,120,121],"Vibration","Hydroxymethylbutyrate","2025-02-12",{"date":124,"type":125},"2025-02-13","ACTUAL",{"date":127,"type":125},"2023-01-12",{"date":129,"type":110},"2025-09",{"name":5,"class":6},3]