[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639306":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":18,"locations":10,"responsibleParty":24,"collaborators":10,"id":28,"slug":29,"hasResults":30,"nctId":31,"briefTitle":32,"officialTitle":33,"acronym":10,"eligibilityCriteria":34,"healthyVolunteers":30,"sex":35,"minAge":36,"maxAge":10,"enrollmentInfo":37,"targetDuration":10,"studyType":40,"phases":10,"briefSummary":41,"conditions":42,"keywords":44,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Acute PE confirmed by computed tomography pulmonary angiogram (CTPA) performed within 24 h",null,[12],"Other: Echo-cardiography",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":10},"Echo-cardiography","All echocardiograms will follow a standardized acquisition protocol based on the American Society of Echocardiography and European Association of Cardiovascular Imaging recommendations for RV assessment. Key elements:\n\n* Left lateral decubitus position when tolerated; semi-recumbent if dyspneic.\n* ECG-gated digital loops of at least three consecutive cardiac cycles for each view.\n* Mandatory views: parasternal long-axis and short-axis; apical four-chamber, RV-focused four-chamber, two-chamber, and three-chamber; subcostal four-chamber and IVC.\n* M-mode through the lateral tricuspid annulus for TAPSE.\n* Continuous-wave Doppler across the tricuspid valve for peak TR velocity (multiple windows attempted; agitated saline contrast may be used to improve TR signal at operator discretion).\n* Tissue Doppler at the lateral tricuspid annulus for S",[9],[19],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Entsar Hsanen Mohamed, lecturer","CONTACT","+201019968106","entsar.hsanen@aun.edu.eg",{"type":25,"investigatorFullName":26,"investigatorTitle":27,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Entsar Hsanen","lecturer","100639306","rdw-and-rv-pa-coupling-in-acute-pe-100639306",false,"NCT07616557","RDW and RV-PA Coupling in Acute PE","Association Between Admission Red Cell Distribution Width and Right Ventricular-Pulmonary Arterial Coupling in Acute Pulmonary Embolism","Inclusion Criteria:\n\nAge ≥ 18 years. Acute PE confirmed by computed tomography pulmonary angiogram (CTPA) performed within 24 h of presentation.\n\nCBC obtained within 24 h of admission and before any blood transfusion. Transthoracic echocardiography feasible within 24 h of admission. Written informed consent.\n\nExclusion Criteria:\n\n* Active hematologic malignancy or recent chemotherapy with myelosuppressive intent.\n* Red blood cell transfusion within the preceding 90 days.\n* Known hemoglobinopathy (e.g., sickle cell disease, thalassemia major).\n* Chronic dialysis or eGFR \\\u003C 15 mL\u002Fmin\u002F1.73 m².\n* Pre-existing severe pulmonary hypertension (resting mean PAP ≥ 35 mmHg by prior right heart catheterization or echocardiographic PASP ≥ 60 mmHg before this admission), severe left-sided valvular disease, or known severe biventricular dysfunction.\n* Hemodynamic instability requiring vasopressors at the time of echocardiography, as their hemodynamics may distort RV-PA coupling estimates.\n* Inadequate echocardiographic image quality precluding measurement of TAPSE and a quantifiable TR jet for PASP estimation.\n* Inability to provide informed consent.","ALL","18 Years",{"count":38,"type":39},190,"ESTIMATED","OBSERVATIONAL","Prior work linking RDW to echocardiographic findings in PE has largely focused on isolated parameters such as TAPSE or PASP and has rarely incorporated modern measures of RV-PA coupling. Whether admission RDW reflects the integrated RV-PA interaction - and not merely contractility or pressure in isolation - has not been adequately addressed. Establishing this link would support RDW as a simple, universally available marker of RV vulnerability at first presentation, and would lay the groundwork for future prognostic and mechanistic studies.",[43],"Pulmonary Embolism Acute",[45,46,47],"Embolism","RDW","Right Ventricular-Pulmonary Arterial Coupling","NOT_YET_RECRUITING","2026-05-27",{"date":51,"type":52},"2026-06-01","ACTUAL",{"date":54,"type":39},"2026-06-15",{"date":56,"type":39},"2027-12-15",{"name":5,"class":6}]