[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581036":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":39,"responsibleParty":85,"collaborators":89,"id":94,"slug":95,"hasResults":96,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":96,"sex":102,"minAge":103,"maxAge":25,"enrollmentInfo":104,"targetDuration":25,"studyType":107,"phases":108,"briefSummary":110,"conditions":111,"keywords":113,"overallStatus":122,"whyStopped":25,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":132},{"fullName":5,"class":6},"Aarhus University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"vein re-isolation plus VOM ablation and block of mitral and tricuspid isthmuses and dome line","EXPERIMENTAL","pulmonary vein re-isolation plus Vein of Marshall ethanol ablation in combination with block of mitral and tricuspid isthmuses and dome line",[13],"Procedure: Intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"vein re-isolation","ACTIVE_COMPARATOR","pulmonary vein re-isolation",[19],"Procedure: Control",[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Intervention",[9],null,{"type":22,"name":27,"description":17,"armGroupLabels":28,"otherNames":25},"Control",[15],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Peter Lukac, MD, PhD","CONTACT","+45 40293641","peteluka@rm.dk",{"name":36,"role":32,"phone":37,"phoneExt":25,"email":38},"Mads Brix Kronborg, MD, PhD, DMSc","+ 45 29896776","madskron@rm.dk",[40,52,69],{"facility":41,"status":25,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":25,"geoPoint":25,"contacts":47},"Department of Cardiology, Aarhus University Hospital","Århus N","Danmark","8250","Denmark","DK",[48,49],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},{"name":50,"role":32,"phone":51,"phoneExt":25,"email":38},"Mads Brix Lukac, MD, PhD, DMSc","+45 29896776",{"facility":53,"status":25,"city":54,"state":25,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Department of Cardiology, Leiden University Medical Center","Leiden","2333","Netherlands","NL",{"type":59,"coordinates":60},"Point",[61,62],4.49306,52.15833,{"lat":62,"lon":61},[65],{"name":66,"role":32,"phone":67,"phoneExt":25,"email":68},"Sebastiaan Piers, MD, PhD","+31 71 526 20 20","S.R.D.Piers@lumc.nl",{"facility":70,"status":25,"city":71,"state":25,"zip":72,"country":73,"countryCode":74,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Department of Cardiology, Karolinska University Hospital, Stockholm","Stockholm","17176","Sweden","SE",{"type":59,"coordinates":76},[77,78],18.06871,59.32938,{"lat":78,"lon":77},[81],{"name":82,"role":32,"phone":83,"phoneExt":25,"email":84},"Finn Åkerström, MD, PhD","+46 734646045","finn.akerstrom@regionstockholm.se",{"type":86,"investigatorFullName":87,"investigatorTitle":88,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Peter Lukac","Consultant",[90,92],{"name":91,"class":6},"Karolinska University Hospital",{"name":93,"class":6},"Leiden University Medical Center","100581036","re-ablation-of-persistent-atrial-fibrillation-100581036",false,"NCT06845085","Re-ablation of Persistent Atrial Fibrillation","Re-ablation of Persistent Atrial Fibrillation: a Randomized Study, Evaluating Vein of Marshall Ethanol Ablation in Combination With Block of Mitral and Tricuspid Isthmuses and Dome Line","Re-AF","Inclusion Criteria:\n\n* Previous pulmonary vein isolation for atrial fibrillation\n* Indication for catheter ablation with at least two episodes of symptomatic PsAF during the last 12 months\n* Age \\> 18 years\n* Expected survival \\> 12 months\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Previous extrapulmonary atrial ablation other than cavotricuspid isthmus line, roof- or dome line or posterior wall isolation\u002Fablation\n* Atypical atrial flutter in addition to atrial fibrillation\n* Atrial fibrillation secondary to a transient abnormality\n* Uncontrolled hypertension\n* Acute coronary syndrome, cardiac surgery, or TIA\u002Fstroke within the last 3 months\n* Planned cardiac surgery within 1 year\n* Dialysis or severe renal failure\n* Active substance or alcohol abuse (\\>14 units\u002Fweek)","ALL","18 Years",{"count":105,"type":106},180,"ESTIMATED","INTERVENTIONAL",[109],"NA","Pulmonary vein re-isolation plus Vein of Marshall ethanol ablation in combination with block of mitral and tricuspid isthmuses and dome line will be compared to pulmonary vein re-isolation alone in patients undergoing re-ablation for persistent atrial fibrillation in this investigator initiated, randomized, patient-assessor blinded multicenter trial. Patients are followed with standard ECG at 3 months, with standard ECG, 5-days' ECG monitoring and quality of life assessment after 12 months, with standard ECG and quality of life assessment after 24 months, through patient files at 60 months after the ablation.\n\nPrimary endpoint: Change in AFEQT score between baseline and 12 months.",[112],"Atrial Fibrillation, Persistent",[114,115,116,117,118,119,120,121],"Persistent atrial fibrillation","Radiofrequency ablation","Pulsed field ablation","Vein of Marshall alcohol ablation","Cavotricuspid isthmus line","Mitral isthmus line","Dome line","Pulmonary vein re-isolation","NOT_YET_RECRUITING","2025-02-26",{"date":125,"type":126},"2025-02-28","ACTUAL",{"date":128,"type":106},"2025-03",{"date":130,"type":106},"2032-10",{"name":5,"class":6},3]