[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100523249":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":24,"centralContacts":29,"locations":23,"responsibleParty":39,"collaborators":42,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":23,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":23,"overallStatus":76,"whyStopped":23,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":23},{"fullName":5,"class":6},"Rigshospitalet, Denmark","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"A","Primary radiotherapy 54Gy\u002F30 fractions",[12],"Radiation: Re-irradiation",{"label":14,"type":6,"description":15,"interventionNames":16},"B","Any other dose and fractionation for primary radiotherapy than 54gy\u002F30 fractions.",[12],[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"RADIATION","Re-irradiation","20Gy on 10 fractions",[9,14],null,[25],{"name":26,"affiliation":27,"role":28},"Maja V Maraldo","Department of oncology and radiotherapy, Copenhagen University Hospital Rigshospitalet","PRINCIPAL_INVESTIGATOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":23,"email":34},"Daniella Østergaard","CONTACT","+4520822297","daniella.elisabet.oestergaard.01@regionh.dk",{"name":36,"role":32,"phone":37,"phoneExt":23,"email":38},"Maja V. Maraldo","+4535451117","Maja.Vestmoe.Maraldo@regionh.dk",{"type":28,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Maja Maraldo","Consultant, Head of breast and paediatric radiotherapy",[43,45,47,49],{"name":44,"class":6},"Aarhus University Hospital",{"name":46,"class":6},"Sahlgrenska University Hospital",{"name":48,"class":6},"Karolinska University Hospital",{"name":50,"class":51},"Radiumhospitalet, Oslo University Hospital","UNKNOWN","100523249","re-irradiation-of-diffuse-midline-glioma-patients-100523249",false,"NCT06093165","RE-irradiation of Diffuse MIdline Glioma paTients","REMIT","Inclusion Criteria:\n\n* Diffuse midline glioma diagnosis: verified radiologically or histologically Biopsy is not mandatory for REMIT\n* Age ≥ 12 months to ≤21 years.\n* Min. 180 days\u002F6 months have elapsed from the first day of the 1st RT course\n* 1st course of radiotherapy\n* Full recovery from all acute and subacute toxicities of 1st RT course\n* Clinical progression of symptoms and\u002For radiographic progression\n* Karnofsky performance status scale or Lansky Play Scale \\> 50% The performance status should not take the neurological deficits per se into account.\n\nNB: Children and adults with a worsening performance status due to glioma-related motor deficit can be included.\n\n* Life expectancy \\> 12 weeks after start of reRT\n* Signed informed consent by patient and\u002For parents or legal guardian\n\nExclusion Criteria:\n\n* Presence of leptomeningeal spread or multifocal disease on MRI at progression\n* Other co-morbidity that according to the treating physician would impair participation in the study\n* \\>1 course of radiotherapy\n* Neurofibromatosis type 1\n* Inability to complete the medical follow-up (geographic, social, or mental reasons)","ALL","12 Months","21 Years",{"count":63,"type":64},59,"ESTIMATED","INTERVENTIONAL",[67],"NA","The REMIT (RE-irradiation of diffuse MIdline glioma paTients) study evaluates safety and the palliative efficacy of re-irradiation of patients with diffuse midline glioma (DMG). The study will introduce a standard re-irradiation treatment schedule for DMG patients who have progressed following primary treatment.",[70,71,72,73,74,75],"Diffuse Midline Glioma, H3 K27M-Mutant","Diffuse Intrinsic Pontine Glioma","Diffuse Glioma","Pontine Tumors","Thalamic Tumor","Brain Tumor, Pediatric","NOT_YET_RECRUITING","2023-10-16",{"date":79,"type":80},"2023-10-23","ACTUAL",{"date":82,"type":64},"2023-10",{"date":84,"type":64},"2029-11",{"name":5,"class":6}]