[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627403":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":7,"locations":12,"responsibleParty":33,"collaborators":7,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":39,"acronym":40,"eligibilityCriteria":41,"healthyVolunteers":37,"sex":42,"minAge":43,"maxAge":7,"enrollmentInfo":44,"targetDuration":7,"studyType":47,"phases":7,"briefSummary":48,"conditions":49,"keywords":53,"overallStatus":15,"whyStopped":7,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":67},{"fullName":5,"class":6},"Istituti Clinici Scientifici Maugeri SpA","OTHER",null,[9],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"ecological momentary assessment","A real-time data collection method involving brief, repeated digital surveys completed by participants in their natural environments. Participants will receive two notifications every other day for 8 weeks via a mobile application. Surveys are designed to assess physical symptoms, socio-occupational status, and emotional states related to Hereditary Angioedema (HAE) to capture daily fluctuations in disease burden.",[13],{"facility":14,"status":15,"city":16,"state":7,"zip":17,"country":18,"countryCode":19,"cosmosGeoPoint":20,"geoPoint":25,"contacts":26},"Istituti Clinici Scientifici Maugeri, Milan, Milan 20138","RECRUITING","Milan","20138","Italy","IT",{"type":21,"coordinates":22},"Point",[23,24],9.18951,45.46427,{"lat":24,"lon":23},[27],{"name":28,"role":29,"phone":30,"phoneExt":31,"email":32},"Francesca Perego, MD, PhD","CONTACT","0250725239","+39","francesca.perego@icsmaugeri.it",{"type":34,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100627403","real-life-ecological-momentary-assessment-of-lived-burden-in-hereditary-angioedema-100627403",false,"NCT07448181","Real-life Ecological Momentary Assessment of Lived Burden in Hereditary AngioEdema","REAL-HAE","Inclusion Criteria:\n\n* Confirmed diagnosis of Type 1 or Type 2 hereditary angioedema;\n* Age ≥ 18 years;\n* Ability to understand instructions and provide informed consent;\n* Ownership and proficiency in using a personal smartphone compatible with the m-Path application (Android or iOS);\n* Willingness to participate in the study for the entire duration of the observation period (8 weeks).\n\nExclusion Criteria:\n\n* Diagnosis of acquired angioedema or other forms of angioedema unrelated to C1-inhibitor deficiency;\n* Severe cognitive or psychiatric disorders that compromise the ability to complete the questionnaires independently;\n* Age \\\u003C 18 years;","ALL","18 Years",{"count":45,"type":46},30,"ESTIMATED","OBSERVATIONAL","The aim of this study is to conduct an in-depth analysis of the Burden of Disease (BoD) perceived by patients with Hereditary Angioedema (HAE), through daily prospective observations based on Ecological Momentary Assessment (EMA) via digital surveys and standardised questionnaires.\n\nParticipants will answer online survey questions about their perceived burden of disease for 8 consecutive weeks. The main hypothesis is that daily prospective observation (EMA) will reveal a higher and more fluctuating burden of disease compared to traditional retrospective scales, providing a more accurate representation of the impact of HAE on patients' daily lives.",[50,51,52],"Hereditary Angioedema With C1 Esterase Inhibitor Deficiency","Hereditary Angioedema - Type 1","Hereditary Angioedema - Type 2",[54,55,56,57],"Hereditary Angioedema","Burden of disease","Ecological Momentary Assessment","Quality of Life","2026-03-03",{"date":60,"type":61},"2026-03-04","ACTUAL",{"date":63,"type":61},"2026-02-23",{"date":65,"type":46},"2027-02-28",{"name":5,"class":6},1]