[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100462291":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":44,"responsibleParty":64,"collaborators":67,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":25,"eligibilityCriteria":80,"healthyVolunteers":76,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":25,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":95,"overallStatus":47,"whyStopped":25,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"Boston VA Research Institute, Inc.","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"stg-rt-fMRI","EXPERIMENTAL","will receive feedback from the STG",[13],"Other: stg-rt-fMRI-Neurofeeback",{"label":15,"type":16,"description":17,"interventionNames":18},"sham-rt-fMRI","SHAM_COMPARATOR","will receive feedback from the motor cortex",[19],"Other: sham-rt-fMRI-Neurofeedback",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"stg-rt-fMRI-Neurofeeback","the patients will receive real-time feedback from the brain activity of the superior temporal gyrus",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"sham-rt-fMRI-Neurofeedback","the patients will receive real-time feedback from the brain activity of the somato-motor cortex",[15],[31],{"name":32,"affiliation":5,"role":33},"margaret niznikiewicz","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"margaret niznikiewicz, PhD","CONTACT","6176534627","margaret_niznikiewicz@hms.harvard.edu",{"name":41,"role":37,"phone":42,"phoneExt":25,"email":43},"Clemens Bauer, phd","617-870-1771","c.bauer@northeastern.edu",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Boston VA Healthcare System, Brockton","RECRUITING","Brockton","Massachusetts","02301","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-71.01838,42.08343,{"lat":57,"lon":56},[60],{"name":61,"role":37,"phone":62,"phoneExt":25,"email":63},"Mia Kriksciun, BA","774 826 1507","mia.kriksciun@va.gov",{"type":33,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Margaret Niznikiewicz","Professor in Psychiatry",[68,70,72],{"name":69,"class":6},"Mclean Hospital",{"name":71,"class":6},"Northeastern University",{"name":73,"class":6},"Cambridge Health Alliance","100462291","real-time-fmri-neurofeedback-in-patients-with-schizophrenia-and-auditory-hallucinations-100462291",false,"NCT05299749","Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations","Real-time fMRI Neurofeedback as a Tool to Mitigate Auditory Hallucinations in Patients With Schizophrenia - R33 Phase","Inclusion Criteria:\n\n* patients diagnosed with SZ or schizoaffective disorder using DSM-5 criteria\n* auditory hallucinations not responsive to pharmacology as determined by chart review and a clinical interview of SCID.\n\nExclusion Criteria:\n\n* neurologic illness\n* major head trauma\n* electroconvulsive therapy\n* alcohol or drug dependence\n* alcohol or drug abuse within the past five years\n* verbal IQ below 70","ALL","18 Years","55 Years",{"count":85,"type":86},104,"ESTIMATED","INTERVENTIONAL",[89],"NA","Neurofeedback intervention aimed to regulate the superior temporal gyrus (STG) activation and default mode network (DMN) connectivity as well as to reduce the auditory hallucinations (AH) schizophrenia patients with medication resistant AH.",[92,93,94],"Schizophrenia","Auditory Hallucination","Treatment-resistant Schizophrenia",[96,97,98,99,100,101,102],"Auditory-Hallucination","Connectivity","brain-activity","default-mode-network","superior temporal gyrus","Neurofeedback","MRI","2025-09-12",{"date":105,"type":106},"2025-09-18","ACTUAL",{"date":108,"type":106},"2022-03-01",{"date":110,"type":86},"2026-06-30",{"name":5,"class":6},1]