[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633413":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":10,"responsibleParty":21,"collaborators":25,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":54,"sex":58,"minAge":59,"maxAge":10,"enrollmentInfo":60,"targetDuration":63,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":10,"overallStatus":68,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":10},{"fullName":5,"class":6},"Shanghai Public Health Clinical Center","OTHER_GOV",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Opportunistic infection treatment group",null,"Based on the presence of baseline: PCP, tuberculosis, NTM infection, CMV infection, herpes simplex and varicella-zoster virus infection, toxoplasmosis encephalopathy, oral fungal infection, cryptococcal meningitis, Marneffei basket disease, PML is divided into opportunistic infection groups.",{"label":13,"type":10,"description":14,"interventionNames":10},"Non-opportunistic infection group","At baseline, common opportunistic infections common in the AIDS stage were excluded.",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Prof.Yinzhong Shen","CONTACT","+86 18916113951","shenyinzhong@shphc.org.cn",{"type":22,"investigatorFullName":23,"investigatorTitle":24,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Yinzhong Shen","Professor",[26,29,32,34,36,38,40,42,44,46,48,50],{"name":27,"class":28},"Chest Hospital of Guangxi Zhuang Autonomous Region","UNKNOWN",{"name":30,"class":31},"Beijing Ditan Hospital","OTHER",{"name":33,"class":28},"Guangzhou Eighth People's Hospital, Guangzhou Medical University.",{"name":35,"class":31},"The Second Hospital of Nanjing Medical University",{"name":37,"class":28},"Chongqing Public Health Medical Treatment Center",{"name":39,"class":28},"GuiYang Public Health Clinical centre",{"name":41,"class":31},"Chengdu Public Health Clinical Center",{"name":43,"class":6},"The Third People's Hospital of Yunnan Province",{"name":45,"class":31},"Meng Chao Hepatobiliary Hospital of Fujian Medical University",{"name":47,"class":31},"Beijing YouAn Hospital",{"name":49,"class":31},"Peking Union Medical College Hospital",{"name":51,"class":31},"Zhejiang University","100633413","real-world-cohort-study-of-antiretroviral-therapy-in-hiv-patients-with-opportunistic-infections-100633413",false,"NCT07526363","Real-world Cohort Study of Antiretroviral Therapy in HIV Patients With Opportunistic Infections","Inclusion Criteria:\n\n* For the opportunistic infection treatment group: Inclusion criteria: a) Age ≥ 18 years, diagnosed with HIV-1 infection; b) Clinically diagnosed with one of the following opportunistic infections and initiating anti-infective therapy: PCP, tuberculosis, NTM infection, CMV infection, herpes simplex virus and varicella-zoster virus infection, toxoplasmosis encephalopathy, oral fungal infection, cryptococcal meningitis, Marneffei basket disease, PML; c) Intending to initiate ART therapy or currently receiving ART therapy; d) The individual (or their legal representative) voluntarily signs a written informed consent form.\n* For the non-opportunistic infection group: a) Age ≥ 18 years, diagnosed with HIV-1 infection; b) Intending to start ART treatment or currently receiving ART treatment; c) The individual (or legal representative) voluntarily signs a written informed consent form.\n\nExclusion Criteria:\n\n* For the opportunistic infection treatment group: Exclusion criteria: a) Individuals suffering from major neurological or psychiatric illnesses such as schizophrenia, epilepsy, or severe depression; b) Individuals with a history of drug use or recent history of alcohol or drug dependence; c) Individuals deemed unsuitable for participation by researchers, such as those in the acute phase of severe cardiovascular disease; d) Individuals deemed unsuitable for participation by other researchers; e) Individuals whose long-term follow-up requirements and frequency cannot be guaranteed.\n* For the non-opportunistic infection group: a) Individuals with coexisting opportunistic infections; b) Individuals suffering from major neurological or psychiatric illnesses such as schizophrenia, epilepsy, or severe depression; c) Individuals with a history of drug use or recent history of alcohol or drug dependence; d) Individuals deemed unsuitable for participation by researchers, such as those in the acute phase of severe cardiovascular disease; e) Individuals deemed unsuitable for participation by other researchers; f) Individuals whose long-term follow-up requirements and frequency cannot be guaranteed.","ALL","18 Years",{"count":61,"type":62},8000,"ESTIMATED","30 Months","OBSERVATIONAL","This study stratified and compared the differences in virological efficacy and sustained viral suppression status between HIV-infected patients with and without opportunistic infections, providing a basis for optimizing antiretroviral therapy for opportunistic infections and a data foundation for establishing predictive models.",[67],"Opportunistic Infections, HIV Related","NOT_YET_RECRUITING","2026-04-06",{"date":71,"type":72},"2026-04-13","ACTUAL",{"date":74,"type":62},"2026-05-01",{"date":76,"type":62},"2029-06-01",{"name":5,"class":6}]