[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573488":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":45,"responsibleParty":64,"collaborators":25,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":25,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":25,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":48,"whyStopped":25,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Group B polytetrafluoroethylene membrane.","ACTIVE_COMPARATOR","Particulate bone mixture 1:1 autogenous and xenogenic bone covered with polytetrafluoroethylene membrane.",[13],"Procedure: Polytetrafluoroethylene membrane.",{"label":15,"type":16,"description":17,"interventionNames":18},"Study Group A native collagen membrane.","EXPERIMENTAL","Particulate bone mixture 1:1 autogenous and xenogenic bone covered with native collagen membrane.",[19],"Procedure: Collagen membrane.",[21,26],{"type":22,"name":23,"description":17,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Collagen membrane.",[15],null,{"type":22,"name":27,"description":11,"armGroupLabels":28,"otherNames":25},"Polytetrafluoroethylene membrane.",[9],[30],{"name":31,"affiliation":32,"role":33},"Ahmed M. Youssef, PHD.","Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Egypt","STUDY_DIRECTOR",[35,41],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"Mohannad A. Ismail, MSc.","CONTACT","+201222968444","+20","mohannadahmed@hotmail.com",{"name":42,"role":37,"phone":43,"phoneExt":39,"email":44},"Zeyad adel Mostafa., MSc.","+201062227776","zeyad.adel@dentistry.cu.edu.eg",[46],{"facility":47,"status":48,"city":49,"state":25,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Faculty of Dentistry Cairo University","RECRUITING","Cairo","11553","Egypt","EG",{"type":54,"coordinates":55},"Point",[56,57],31.24967,30.06263,{"lat":57,"lon":56},[60],{"name":61,"role":37,"phone":62,"phoneExt":39,"email":63},"Ahmed M. Youssef, Lecturer","+201067941236","ahmed.youssef@dentistry.cu.edu.eg",{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Mohannad Ahmed Ismail","Principle Investigator","100573488","reconstruction-of-deficient-atrophic-ridges-using-guide-bone-regeneration-technique-100573488",false,"NCT06746935","Reconstruction of Deficient Atrophic Ridges Using Guide Bone Regeneration Technique","Reconstruction of Deficient Atrophic Ridges Using Guided Bone Regeneration Technique With Native Collagen Membrane and Polytetrafluoroethylene Membrane (Randomized Clinical Trial)","Inclusion Criteria:\n\n* Patients with maxillary residual alveolar bone height not less than 8 mm.\n* Alveolar bone width from less than or equal 5 mm.\n* Both sexes.\n* At least missing single tooth.\n* Previous Failed Implants.\n* Previous Failed Grafting.\n\nExclusion Criteria:\n\n* Heavy smokers more than 20 cigarettes per day.\n* Patients with bone disease that may affect normal healing, example; hyperparathyroidism.\n* Patients had radiotherapy and chemotherapy in head and neck.\n* Patients had neoplasms in sites to be grafted.\n* Patients with Metabolic diseases uncontrolled diabetic patients, Glycated hemoglobin (Hb A1c) more than 7 mg\\\\dl.","ALL","20 Years","48 Years",{"count":79,"type":80},20,"ESTIMATED","INTERVENTIONAL",[83],"NA","patients will be informed of the nature of the research work and informed consent will be obtained then randomized in 2 groups. Mixture 1:1 autogenous and xenogenic bone covered with Polytetrafluoroethylene membrane control group and study group p covered with native collagen membrane.\n\n* Patients of both groups will be subjected to CBCT (diagnostic for upper arch), diagnostic wax-up and stent fabrication.\n* Intra operative procedures (for both groups) followed by CBCT will be taken for every patient after 4 months.\n\nBoth the study and control group will receive:\n\n* In Recipient site, using 15C blade on Bard Parker handle incision of full thickness mucoperiosteal flap inorder to obtain, three-line pyramidal flap, reflection using mucoperiosteal elevator molt 9.\n* The defective site is reevaluated after its primary evaluation on CBCT using UNC (University of North Carolina) periodontal probe and a template is cut using sterile suture pack, prior to donor site preparation.\n* Flap advancement using periosteal releasing incision inorder to allow later tension free flap closure.\n* In Donor site, mucoperiosteal flap is done, auto chip maker (ACM) is used for autogenous bone harvesting.\n* Autogenous particulate bone graft is obtained using auto chip maker bur (ACM), in implant contra 20:1 using surgical motor recommended drilling speed 100 rpm and maximum torque 50 Ncm. as well as, using bone scrapper in push direction.\n* Xenogenic bone graft particles (De-proteinized bovine bone mineral small granules (0.25-1 mm). is added to the autogenous bone particles to obtain homogenous mixture ratio 1:1.\n* The gold standard is a mixture of autogenous bone containing viable cells and xenogenic bone which has slower rate of resorption is to be placed in recipient decorticated site and covered by PTFE membrane.\n* The assemble is to be fixed by titanium bone tacks of diameter 2.5 mm and length 3.5 mm, to avoid micro movements of particulate bone assembly.\n* In the Study group: The assemble is going to be covered by resorbable collagen membrane and fixed by tacks.\n* Recheck adequate flap advancement by visualizing passive flap approximation, to allow tension free closure.\n* Double line closure using horizontal mattress placed 5mm away from flap margins followed by interrupted sutures on top to allow contact area which is preferred to point contact and wound edge eversion.",[86,87],"Ridge Augmentation","Bone Augmentation",[89,90,91],"ridge augmentation","Polytetrafluoroethylene","native collagen membrane","2025-02-16",{"date":94,"type":95},"2025-02-19","ACTUAL",{"date":97,"type":95},"2025-01-01",{"date":99,"type":80},"2025-10-29",{"name":5,"class":6},1]