[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100529740":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":21,"responsibleParty":40,"collaborators":10,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":10,"enrollmentInfo":53,"targetDuration":10,"studyType":56,"phases":10,"briefSummary":57,"conditions":58,"keywords":10,"overallStatus":64,"whyStopped":10,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},{"fullName":5,"class":6},"Institut universitaire de cardiologie et de pneumologie de Québec, University Laval","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with diagnosis of probable\u002Fdefinite DRT after LAAO",null,"Patients with diagnosis of probable\u002Fdefinite DRT after LAAO detected by transesophageal echocardiography (TEE) or cardiac computed tomography (CT).\n\nIn all patients after the LAAO procedure, a first imaging evaluation at 45 to 90 days, and a second imaging evaluation at 12 months is recommended.\n\nIn case of DRT diagnosis, and following the recent SCAI\u002FHRS recommendations, a repeat imaging at 45- to 90-day intervals is recommended to assess for DRT resolution with eventual cessation of anticoagulation.\n\nIn case of DRT resolution, a sequential imaging evaluation at ±90-day, ±180-day, and ±365 days after the imaging test where DRT was resolved is recommended",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Josep Rodes-Cabau, MD, PhD","CONTACT","14186568711","josep.rodes@criucpq.ulaval.ca",{"name":19,"role":15,"phone":16,"phoneExt":10,"email":20},"Melanie Cote, MSc","melanie.cote@criucpq.ulaval.ca",[22],{"facility":23,"status":10,"city":24,"state":25,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"IUCPQ-UL","Québec","Quebec","G1V 4G5","Canada","CA",{"type":30,"coordinates":31},"Point",[32,33],-71.21454,46.81228,{"lat":33,"lon":32},[36],{"name":37,"role":15,"phone":38,"phoneExt":39,"email":20},"Melanie Cote","4186568711","2646",{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Josep Rodes-Cabau","Principal Investigator","100529740","recurrent-or-persistent-device-related-thrombus-after-left-atrial-appendage-occlusion-the-re-drt-study-100529740",false,"NCT06177704","Recurrent or Persistent Device Related Thrombus After Left Atrial Appendage Occlusion: The RE-DRT Study","RE-DRT","Inclusion Criteria:\n\n* Patients with diagnosis of probable\u002Fdefinite DRT after LAAO detected by transesophageal echocardiography (TEE) or cardiac computed tomography (CT).\n* Age≥18 years old.\n\nExclusion Criteria:\n\n* Unable to provide informed consent","ALL","18 Years",{"count":54,"type":55},100,"ESTIMATED","OBSERVATIONAL","This study is a prospective, multicenter international trial aimed at assessing the actual incidence, identifying associated factors, and evaluating the clinical consequences of both persistent and recurrent device-related thrombus (DRT) following percutaneous left atrial appendage occlusion (LAAO).\n\nWhile LAAO has shown efficacy in reducing the risk of stroke, device-related thrombus (DRT) remains a significant concern. The reported incidence of DRT varies, and it is associated with an elevated risk of ischemic stroke and death. The study highlights that persistent and recurrent DRT pose higher risks of thromboembolic events, and current data come from retrospective studies with non-standardized imaging follow-up protocols. The timing of imaging follow-up is crucial, and the study notes discrepancies in recommendations from expert statements. The EHRA\u002FEAPCI suggests imaging at specific intervals post-procedure, while the SCAI\u002FHRS recommends repeat imaging at shorter intervals to assess DRT resolution. The study underscores the need for dedicated prospective data to accurately determine the incidence, factors, and clinical impact of persistent and recurrent DRT after LAAO.",[59,60,61,62,63],"Percutaneous Left Atrial Appendage Occlusion (LAAO)","Device-related Thrombus (DRT)","Thromboembolic Event","Major Cardioembolic Events","Major Bleeding - TIMI Classification","NOT_YET_RECRUITING","2026-03-23",{"date":67,"type":68},"2026-03-24","ACTUAL",{"date":70,"type":55},"2026-12-01",{"date":72,"type":55},"2028-01-01",{"name":5,"class":6},1]