[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608076":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":38,"locations":47,"responsibleParty":65,"collaborators":26,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":26,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":26,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":50,"whyStopped":26,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University of Thessaly","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"N-acetylcysteine","EXPERIMENTAL","Oral N-acetylcysteine supplementation for 12 weeks (2 x 600 mg capsules\u002Fday)",[13],"Dietary Supplement: N Acetyl L Cysteine",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Oral placebo supplementation for 12 weeks (2 placebo capsules\u002Fday)",[19],"Dietary Supplement: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","N Acetyl L Cysteine","Participants will participate in 3 multicomponent high-intensity interval training (m-HIIT) sessions per week over a 12-week period while receiving daily 1200 mg N-acetylcysteine (2 pills x 600 mg\u002Fday ).",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Participants will participate in 3 multicomponent high-intensity interval training (m-HIIT) sessions per week over a 12-week period while receiving daily 2 placebo pills\u002Fday.",[15],[31,35],{"name":32,"affiliation":33,"role":34},"Anastasia Rosvoglou, PhDc","University of Thessaly, Department of Physical Education and Sport Science","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":33,"role":37},"Dimitrios Draganidis, PhD","STUDY_DIRECTOR",[39,43],{"name":36,"role":40,"phone":41,"phoneExt":26,"email":42},"CONTACT","+30 2431047078","ddraganidis@uth.gr",{"name":44,"role":40,"phone":45,"phoneExt":26,"email":46},"Ioannis G. Fatouros, PhD","+30 2431047047","ifatouros@uth.gr",[48],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Department of Physical Education and Sport Science, University of Thessaly","RECRUITING","Trikala","Karies","42100","Greece","GR",{"type":57,"coordinates":58},"Point",[59,60],21.76837,39.55493,{"lat":60,"lon":59},[63,64],{"name":36,"role":40,"phone":41,"phoneExt":26,"email":42},{"name":44,"role":40,"phone":45,"phoneExt":26,"email":46},{"type":34,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Dimitrios Draganidis","Assistant Professor","100608076","redox-status-and-exercise-training-induced-adaptations-100608076",false,"NCT07196852","Redox Status and Exercise Training-induced Adaptations","Effects of N-acetylcysteine on Biological Responses to High-intensity Interval Training in Adults With Overweight\u002FObesity","Inclusion Criteria:\n\n* BMI 25-35 kg\u002Fm2\n* Free of musculoskeletal injuries\n* Free of chronic non-communicable diseases\n* Do not receive any drug therapy\n* Do not receive dietary supplements\n* Normal menstrual cycle (for females)\n* Non smokers\n\nExclusion Criteria:\n\n* NAC intolerance\n* Bleeding disorders\n* Kidney disease\n* Asthma\n* Usage of blood thinners and\u002For angina medication",true,"ALL","30 Years","45 Years",{"count":80,"type":81},60,"ESTIMATED","INTERVENTIONAL",[84],"NA","Excess fat accumulation is a key feature of overweight and obesity that is mainly driven by nutrient overload and insufficient physical activity. White adipose tissue displays lipid overload and hypertrophy accompanied by macrophages infiltration, hypoxia, inflammation and excess production of reactive oxygen species (ROS). An inflammatory response and ROS production are also evident in other metabolism regulating tissues and organs such as skeletal muscle, liver, pancreas and hypothalamus, contributing to a chronic inflammatory state, redox status disturbances and metabolic complications. There is overwhelming evidence showing that adults with overweight\u002Fobesity exhibit lower glutathione (GSH) levels in blood erythrocytes, skeletal muscle cells and subcutaneous and visceral adipose tissue cells. GSH, a tripeptide consisting of the amino acids glutamate, cysteine and glycine, is the most abundant thiol-containing antioxidant in the human body and has been, recently, characterized as a novel therapeutic target for the treatment of numerous chronic diseases, due to its potent intracellular redox buffering capacity. Interestingly, lower GSH levels have been associated with diet-induced weight loss resistance, while enhancement of GSH levels through N-acetylcysteine (NAC) supplementation reduces markers of oxidative stress, inflammation, insulin resistance, hypertension, endothelia dysfunction and improves vitamin D metabolism. NAC is a thiol donor that elicits antioxidant effects by (i) directly scavenging ROS and (ii) providing reduced cysteine through deacetylation, which supports the biosynthesis of endogenous GSH via the activity of γ-glutamylcysteine synthase. The aim of this study is to investigate whether NAC supplementation can enhance the exercise training-induced improvements on physical fitness and metabolic health in adult men and women with overweight\u002Fobesity.",[87,88],"Overweight (BMI > 25)","Obesity",[90,91,9,92],"overweight","obesity","high-intensity interval training","2025-12-09",{"date":95,"type":96},"2025-12-16","ACTUAL",{"date":98,"type":96},"2025-09-22",{"date":100,"type":81},"2026-12-30",{"name":5,"class":6},1]