[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100479368":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":35,"centralContacts":40,"locations":45,"responsibleParty":63,"collaborators":65,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":24,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":24,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":96,"overallStatus":47,"whyStopped":24,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"The University of Texas at Arlington","OTHER",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise Group","EXPERIMENTAL","Binge drinkers who have been assigned to exercise group will receive baseline assessment, 8-week exercise training plus alcohol abstinence intervention, and post-intervention assessment.",[13,14],"Behavioral: Exercise Training","Behavioral: Alcohol Abstinence Intervention",{"label":16,"type":17,"description":18,"interventionNames":19},"Non-exercise Group","ACTIVE_COMPARATOR","Binge drinkers who have been assigned to non-exercise group will receive baseline assessment, 8-week alcohol abstinence intervention, and post-intervention assessment.",[14],{"label":21,"type":22,"description":23,"interventionNames":24},"Alcohol abstainer\u002Fmoderate drinker group","NO_INTERVENTION","Alcohol abstainer\u002Fmoderate drinker will complete baseline assessment only and will not receive any intervention.",null,[26,31],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":24},"BEHAVIORAL","Exercise Training","Subjects will be asked to perform exercise training (high-intensity interval training) under supervision, 3 times per week for 8 weeks. Each training session will last 40 minutes and will consist of 10-minute warm up at 70% of maximal heart rate (HRmax), four 4-minute intervals at 90% of HRmax with 3-min active recovery at 70% of HRmax and 5-minute cool down at 70% of HRmax.",[9],{"type":27,"name":32,"description":33,"armGroupLabels":34,"otherNames":24},"Alcohol Abstinence Intervention","Subjects will be asked to abstain from alcohol for 8 weeks. Education materials and bi-weekly consultations will be provided.",[9,16],[36],{"name":37,"affiliation":38,"role":39},"Chueh-Lung Hwang, PhD","University of Texas at Arlington","PRINCIPAL_INVESTIGATOR",[41],{"name":37,"role":42,"phone":43,"phoneExt":24,"email":44},"CONTACT","8172729722","chuehlung.hwang@uta.edu",[46],{"facility":38,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Arlington","Texas","76010","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-97.10807,32.73569,{"lat":57,"lon":56},[60],{"name":61,"role":42,"phone":62,"phoneExt":24,"email":44},"Chueh-Lung Hwang, PhD, PT","817-272-9722",{"type":64,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[66],{"name":67,"class":68},"National Institute on Alcohol Abuse and Alcoholism (NIAAA)","NIH","100479368","reducing-blood-pressure-in-mid-life-adult-binge-drinkers-100479368",false,"NCT05522075","Reducing Blood Pressure in Mid-life Adult Binge Drinkers","Reducing Blood Pressure in Mid-life Adult Binge Drinkers: the Role of Microvascular Function and Sympathetic Activity","Inclusion Criteria:\n\n* Men and women (50-64 years of age) who do not drink alcohol, who drink at moderate levels, or who binge drink\n* Female subjects will be postmenopausal (i.e., cessation of menses for ≥1 yr).\n* Subjects who can speak and understand English.\n\nExclusion Criteria:\n\n* a history of diabetes, cardiovascular disease, liver, or renal disease\n* current or history of smoking and illicit drug use\n* blood pressure ≥160\u002F100 mm Hg\n* other known traditional cardiovascular disease risks: obesity (BMI≥35 kg\u002Fm2), or hyperlipidemia (total cholesterol\\>230 mg\u002Fdl and\u002For LDL cholesterol\\>160 mg\u002Fdl)\n* active infection (in the past 2 months)\n* a history of seizures, cancer, or inflammatory disease (i.e., gout or rheumatoid)\n* unstable body weight (\\>5% change during the past 6 months)\n* regular aerobic exercise training (i.e., they engage in 30 min of structured aerobic exercise at least 3 times per week)\n* current use of hormone replacement therapy (i.e., estrogen, progesterone, and testosterone)",true,"ALL","50 Years","64 Years",{"count":81,"type":82},55,"ESTIMATED","INTERVENTIONAL",[85],"NA","This study has two phases:\n\nPhase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers\u002Fmoderate drinkers.\n\nPhase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers",[88,89,90,91,92,93,94,95],"Alcohol Drinking","Binge Drinking","Blood Pressure","Alcohol Abstinence","Aging","Lifestyle Factors","Vasodilation","Behavioral Problem",[97,98,99,100,101,102],"Exercise training","High-intensity interval training","Midlife adults","Middle-aged","Microvascular function","Sympathetic nerve activity","2026-05-27",{"date":105,"type":106},"2026-06-01","ACTUAL",{"date":108,"type":106},"2022-11-21",{"date":110,"type":82},"2027-04-30",{"name":5,"class":6},1]