[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100514221":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":30,"locations":38,"responsibleParty":107,"collaborators":109,"id":120,"slug":121,"hasResults":122,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":122,"sex":128,"minAge":17,"maxAge":17,"enrollmentInfo":129,"targetDuration":17,"studyType":132,"phases":133,"briefSummary":135,"conditions":136,"keywords":144,"overallStatus":41,"whyStopped":17,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":158},{"fullName":5,"class":6},"Children's Hospital of Philadelphia","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"PICU Clinicians and Sepsis stakeholders","Clinicians and sepsis stakeholders in the participating sites will be primarily recruited via email. During the course of this multifaceted intervention:\n\n* All the PICU (Pediatric Intensive Care Unit) prescribing clinicians and sepsis stakeholders in the participating sites will receive clinical guidelines, unit-level feedback reports, and education on Vancomycin use during the intervention.\n* Investigators will perform semi-structured interviews with 90 PICU clinicians and sepsis stakeholders.\n* Surveys will be sent to all eligible clinicians, estimated to be up to 2500 individuals across the 4 sites. These structured surveys will be done at baseline and at 9 months post-implementation.",[12],"Behavioral: Multifaceted de-implementation strategy to reduce vancomycin overuse",{"label":14,"type":15,"description":16,"interventionNames":17},"PICU Patients with suspected sepsis","NO_INTERVENTION","Research procedures involving patients will be limited to medical record review. This medical record review will help inform the intervention directed at PICU clinicians\u002Fstakeholders and the assessment of study outcomes. Approximately 50,000 patients will participate in the study. Data elements will be collected at each site and stored as password-protected Comma-separated values (CSV) files. These files will not contain any direct Protected Health Information (PHI) but will contain elements of date (e.g., date of admission, date of suspected sepsis episode). The study Identification (ID) number will be used to identify each unique patient. Each site will collect and store data in compliance with the Children's Hospital of Philadelphia (CHOP) and local Institutional Review Board (IRB) policies.",null,[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","Multifaceted de-implementation strategy to reduce vancomycin overuse","* Clinical guidelines and group-level feedback on vancomycin use will be provided to clinicians\u002Fsepsis stakeholders at each site.\n* The semi-structured interviews will be performed by a trained member of the research team, under the supervision of a medical sociologist who is one of the co-investigators. A semi-structured interview guide will be used during the interviews. Interviews will be recorded and transcribed, then uploaded to a qualitative analysis software for management and coding. Names will not be recorded, and pseudonyms will be used in notes, communications about the study, and any presentations. Verbal consent will be obtained before conducting and recording the interviews.\n* The surveys will be performed using REDCap survey software, and participation will be voluntary. No identifiers will be collected.",[9],[25],"Mixed methods intervention",[27],{"name":28,"affiliation":5,"role":29},"Kathleen Chiotos, MD, MSCE","PRINCIPAL_INVESTIGATOR",[31,35],{"name":28,"role":32,"phone":33,"phoneExt":17,"email":34},"CONTACT","215-590-5505","chiotosk@chop.edu",{"name":36,"role":32,"phone":33,"phoneExt":17,"email":37},"Kai Inoki, MPH","meyahnwid@chop.edu",[39,58,72,91],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Children's Healthcare of Atlanta","RECRUITING","Atlanta","Georgia","30322","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-84.38798,33.749,{"lat":51,"lon":50},[54],{"name":55,"role":32,"phone":56,"phoneExt":17,"email":57},"Preeti Jaggi, MD","404-727-4807","preeti.jaggi@emory.edu",{"facility":59,"status":41,"city":60,"state":61,"zip":62,"country":45,"countryCode":46,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Johns Hopkins Children's Center","Baltimore","Maryland","21287",{"type":48,"coordinates":64},[65,66],-76.61219,39.29038,{"lat":66,"lon":65},[69],{"name":70,"role":32,"phone":17,"phoneExt":17,"email":71},"Pranita Tamma, MD, MPH","ptamma1@jhmi.edu",{"facility":73,"status":41,"city":74,"state":75,"zip":76,"country":45,"countryCode":46,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"St. Louis Children's Hospital","St Louis","Missouri","63110",{"type":48,"coordinates":78},[79,80],-90.19789,38.62727,{"lat":80,"lon":79},[83,87],{"name":84,"role":32,"phone":85,"phoneExt":17,"email":86},"Evan Facer, DO","314-454-6050","facer@wustl.edu",{"name":88,"role":32,"phone":89,"phoneExt":17,"email":90},"Luke Starnes, PhD","314-286-2092","garys@wustl.edu",{"facility":5,"status":41,"city":92,"state":93,"zip":94,"country":45,"countryCode":46,"cosmosGeoPoint":95,"geoPoint":99,"contacts":100},"Philadelphia","Pennsylvania","19146",{"type":48,"coordinates":96},[97,98],-75.16362,39.95238,{"lat":98,"lon":97},[101,102,104],{"name":28,"role":32,"phone":33,"phoneExt":17,"email":34},{"name":103,"role":29,"phone":17,"phoneExt":17,"email":17},"Kathleen Chiotos",{"name":105,"role":106,"phone":17,"phoneExt":17,"email":17},"Rebecca Same","SUB_INVESTIGATOR",{"type":108,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR",[110,111,113,115,117],{"name":40,"class":6},{"name":112,"class":6},"St. Louis Children's Hospital",{"name":114,"class":6},"Johns Hopkins University",{"name":116,"class":6},"University of Pennsylvania",{"name":118,"class":119},"Centers for Disease Control and Prevention","FED","100514221","reducing-empiric-vancomycin-use-in-pediatric-suspected-sepsis-100514221",false,"NCT05975671","Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis","Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis (REVAMP-Sepsis)","REVAMP","Patient Inclusion Criteria:\n\n* Admitted to one of the participating PICUs during the study period\n\nPatient Exclusion Criteria:\n\n* None\n\nClinician Inclusion Criteria:\n\n1. PICU prescribing clinician (including attending physicians, fellows, residents, nurse practitioners, and physician assistants) OR sepsis stakeholder (leader of sepsis quality improvement work, medical director) at one of the participating sites at the time the survey is deployed\n2. Age ≥ 18 years old\n3. Employed by one of the participating sites\n\nClinician Exclusion Criteria:\n\n1. Volunteers or other non-employee hospital staff\n2. Limited English proficiency","ALL",{"count":130,"type":131},52500,"ESTIMATED","INTERVENTIONAL",[134],"NA","The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU).\n\nThere are two groups of subjects in this study: PICU clinicians\u002Fsepsis stakeholders and patients admitted to one of the participating PICUs during the study period. The intervention will at a minimum include:\n\n* Implementation of a clinical guideline indicating when vancomycin should and should not be used\n* Unit-level feedback on overall vancomycin use within and across centers\n* Clinician education.",[137,138,139,140,141,142,143],"Sepsis","Sepsis Mrsa","Sepsis Bacteremia","Antimicrobial - Induced Nephropathy","Sepsis, Severe","Septic Shock","Septic Syndrome",[137,145,146,147,148],"Vancomycin use","methicillin-resistant Staphylococcus aureus (MRSA)","Antibiotic Stewardship","Implementation science","2025-09-17",{"date":151,"type":152},"2025-09-19","ACTUAL",{"date":154,"type":152},"2023-08-21",{"date":156,"type":131},"2026-05",{"name":5,"class":6},4]