[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100535126":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":25,"responsibleParty":38,"collaborators":25,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":25,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":49,"minAge":50,"maxAge":25,"enrollmentInfo":51,"targetDuration":25,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":25,"overallStatus":62,"whyStopped":25,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":25},{"fullName":5,"class":6},"Brigham and Women's Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cardiac Rehabilitation","EXPERIMENTAL","Participants will participate in a 12-week cardiac rehabilitation program",[13],"Behavioral: Cardiac Rehabilitation",{"label":15,"type":16,"description":17,"interventionNames":18},"Attention Control","PLACEBO_COMPARATOR","Participants will not participate in a cardiac rehabilitation program and will receive phone calls in place of cardiac rehabilitation visits.",[19],"Behavioral: Attention Control",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Participation in a 12-week cardiac rehabilitation program",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Participants will receive regular phone calls in place of cardiac rehabilitation visits",[15],[30],{"name":31,"affiliation":5,"role":32},"Sheila Hegde, MD","PRINCIPAL_INVESTIGATOR",[34],{"name":31,"role":35,"phone":36,"phoneExt":25,"email":37},"CONTACT","6177325500","shegde@bwh.harvard.edu",{"type":32,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Sheila M. Hegde, MD","Principal Investigator, Assistant Professor of Medicine","100535126","reducing-heart-failure-risk-in-late-life-with-physical-activity-100535126",false,"NCT06247774","Reducing Heart Failure Risk in Late-Life With Physical Activity","Reducing Heart Failure Risk in Late-Life With Physical Activity: Impact on Cardiac Structure and Function and Proteomic Signatures","Inclusion Criteria:\n\n* Hypertension (controlled on stable medication regimen)\n* Structural heart abnormality (LVH or LA enlargement)\n* LVEF \\> 50%\n* Sedentary\n* BMI \\\u003C30\n\nExclusion Criteria:\n\n* Diabetes\n* Unable to exercise\n* Supplemental oxygen use\n* Pulmonary hypertension\n* Sleep apnea\n* Regular exercise training\n* Devices that limit ability to achieve target heart rate\n* Moderate to severe valve disease\n* Recent (within 3 months) major CV event or planned procedures (within 6 months)\n* Terminal illness, life expectancy \\\u003C6 months\n* Inability or unwillingness to comply with study requirements\n* No access to smart phone\u002Ftablet",true,"ALL","65 Years",{"count":52,"type":53},42,"ESTIMATED","INTERVENTIONAL",[56],"NA","The goal of this clinical trial is to learn about the molecular pathways associated with the benefit of a regular exercise program in patients with high blood pressure and who don't already participate in regular exercise.\n\nThe main question it aims to answer is to identify protein signatures associated with the benefits of a cardiac rehabilitation exercise program.\n\nThe trial will enroll 42 participants, who will be randomized to a 12 week cardiac rehabilitation exercise program versus control arm and asked to participate in the following at the beginning and end of study:\n\n* Cardiopulmonary exercise test (CPET)\n* Echocardiogram\n* Physical function test\n* 6-minute walk test\n* Hand grip strength\n* Quality of life questionnaire\n* Blood draws\n\nResearchers will compare results between those who do and don't participate in the exercise program.",[59,60,9,61],"Hypertension","Exercise Training","Proteomics","NOT_YET_RECRUITING","2026-03-10",{"date":65,"type":66},"2026-03-12","ACTUAL",{"date":68,"type":53},"2026-06",{"date":70,"type":53},"2029-05",{"name":5,"class":6}]