[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100536985":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":34,"locations":35,"responsibleParty":59,"collaborators":34,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":34,"enrollmentInfo":70,"targetDuration":34,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":34,"overallStatus":38,"whyStopped":34,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Centre hospitalier de l'Université de Montréal (CHUM)","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Endoscopic Mucosal Resection (EMR)+Hybrid Argon Plasma Coagulation (h-APC)","EXPERIMENTAL","Standard endoscopic mucosal resection (EMR) technique will be used for the primary removal of all polyps, utilizing submucosal injection. Electrocautery snare technique will be facilitated using standard microprocessor-controlled electrocautery (e.g., ERBE VIO Endocut 3-1-6). Ablation of the margin and base of the polypectomy site will be performed using Hybrid Argon Plasma Coagulation (h-APC, Erbe Hybrid APC).",[13],"Procedure: Hybrid Argon Plasma Coagulation (h-APC)",{"label":15,"type":16,"description":17,"interventionNames":18},"Endoscopic Mucosal Resection (EMR) + Snare tip soft coagulation (STSC)","ACTIVE_COMPARATOR","Standard endoscopic mucosal resection (EMR) technique will be used for the primary removal of all polyps, utilizing submucosal injection. Electrocautery snare technique will be facilitated using standard microprocessor-controlled electrocautery (e.g., ERBE VIO Endocut 3-1-6). Ablation of the margin of the polypectomy site will be performed using Snare tip soft coagulation (STSC).",[19],"Procedure: Snare tip soft coagulation (STSC)",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Hybrid Argon Plasma Coagulation (h-APC)","The hybrid argon plasma coagulation (h-APC) combines an ablation technique (APC) with the option for submucosal saline injection using a high-pressure water jet. The technique allows for the lifting of dysplastic epithelium, creating a cushion under the mucosa to facilitate the ablation of larger areas more thoroughly and with higher energy settings, while posing a low risk for side effects or complications.",[9],[27],"h-APC",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Snare tip soft coagulation (STSC)","The Snare tip soft coagulation (STSC) involves using a snare to remove polyps, while simultaneously applying soft coagulation to the surrounding tissue using a specialized tip on the snare.",[15],[33],"STSC",null,[36],{"facility":37,"status":38,"city":39,"state":40,"zip":34,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Centre Hospitalier de l'Université de Montréal","RECRUITING","Montreal","Quebec","Canada","CA",{"type":44,"coordinates":45},"Point",[46,47],-73.58781,45.50884,{"lat":47,"lon":46},[50,56],{"name":51,"role":52,"phone":53,"phoneExt":54,"email":55},"Julie Fleury","CONTACT","514-890-8000","30917","julie.fleury.chum@ssss.gouv.qc.ca",{"name":57,"role":58,"phone":34,"phoneExt":34,"email":34},"Daniel Von Renteln, MD","PRINCIPAL_INVESTIGATOR",{"type":60,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR","100536985","reducing-neoplasia-recurrence-after-endoscopic-resection-of-large-colorectal-polyps-100536985",false,"NCT06271941","Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps","ABLATION","Inclusion Criteria:\n\n* adult ≥18 years old\n* patients undergoing EMR for a large (≥20mm) colorectal LSL\n* patients providing written and informed consent for study participation.\n\nExclusion Criteria:\n\n* inflammatory bowel disease;\n* non-elective colonoscopy;\n* poor general health (American Society of Anesthesiologists classification \\>III);\n* coagulopathy or thrombocytopenia (international normalized ratio ≥1.5 or platelets \\\u003C50 x 109\u002FL);\n* pedunculated polyps (Paris class Ip, Isp);\n* overt signs of deep submucosal invasive cancer (JNET 3);\n* biopsy proven invasive carcinoma in a potential study polyp.\n* Pregnant women","ALL","18 Years",{"count":71,"type":72},892,"ESTIMATED","INTERVENTIONAL",[75],"NA","Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors. Such polyps have to be completely removed to prevent CRC and to avoid surgery and\u002For adjuvant therapy. The laterally spreading lesions (LSLs) are removed via endoscopic mucosal resection (EMR). However, recurrence is common. New techniques for LSL resection (hybrid argon plasma coagulation (h-APC) margin and base ablation) have shown a reduction in recurrence following the interventions.\n\nWe hypothesize that performing hybrid argon plasma coagulation (h-APC) margin and base ablation during EMR of large (≥20mm) colorectal LSLs will lead to lower rates of lesion recurrence compared to Snare tip soft coagulation (STSC) margin ablation.",[78,79],"Colorectal Cancer","Polyp of Colon","2024-11-21",{"date":82,"type":83},"2024-11-25","ACTUAL",{"date":85,"type":83},"2024-07-19",{"date":87,"type":72},"2028-04-01",{"name":5,"class":6},1]