[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611610":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":31,"responsibleParty":54,"collaborators":26,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":26,"enrollmentInfo":65,"targetDuration":26,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":26,"overallStatus":75,"whyStopped":26,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Centre hospitalier de l'Université de Montréal (CHUM)","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Endoscopic mucosal resection (EMR) + adjuvant thermal ablation","EXPERIMENTAL","Adjuvant thermal ablation will be applied to the base and outside margins of the resection site after non-thermal EMR.",[13],"Procedure: Adjuvant thermal ablation",{"label":15,"type":16,"description":17,"interventionNames":18},"Endoscopic mucosal resection (EMR)","ACTIVE_COMPARATOR","After non-thermal EMR, no adjuvant thermal ablation will be performed.",[19],"Procedure: No adjuvant thermal ablation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Adjuvant thermal ablation","When the endoscopist determines that the resection is complete, submucosal injection (0.9% NaCl with methylene blue solution) using the h-APC probe (ERBEJET 2 attached to Vio3 electrosurgical unit, pressure: 40 bar) will be performed to further expose the resection margin. Adjuvant thermal ablation will be applied to the outside margins of the resection site using the h-APC probe.\n\nAdjuvant thermal ablation will then also be applied to the base of the resection site using the h-APC probe. The precise electrocautery mode (PRECISE-APC setting 9) will be used to apply thermal ablation, as previously described for h-APC.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"No adjuvant thermal ablation","After performing non-thermal EMR with thermal ablation, adjuvant thermal ablation will not be performed.",[15],[32],{"facility":33,"status":26,"city":34,"state":35,"zip":26,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Centre Hospitalier de l'Université de Montréal","Montreal","Quebec","Canada","CA",{"type":39,"coordinates":40},"Point",[41,42],-73.58781,45.50884,{"lat":42,"lon":41},[45,51],{"name":46,"role":47,"phone":48,"phoneExt":49,"email":50},"Samira Hanin","CONTACT","514-890-8000","30916","samira.hanin.chum@ssss.gouv.qc.ca",{"name":52,"role":53,"phone":26,"phoneExt":26,"email":26},"Daniel von Renteln, MD","PRINCIPAL_INVESTIGATOR",{"type":55,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100611610","reducing-neoplasia-recurrence-after-non-thermal-endoscopic-resection-of-large-colorectal-polyps-100611610",false,"NCT07242820","Reducing Neoplasia Recurrence After Non-thermal Endoscopic Resection of Large Colorectal Polyps","COSA-RCT","Inclusion Criteria:\n\n* Adult patients\n* Undergoing EMR for large (≥20 mm) colorectal LSL\n* Providing written and informed consent for study participation\n\nExclusion Criteria:\n\n* Inflammatory bowel disease\n* Non-elective colonoscopy\n* Poor general health (American Society of Anesthesiologists classification \\>III)\n* Coagulopathy or thrombocytopenia (international normalized ration ≥1.5 or platelets \\\u003C50\\*10\\^9\u002FL)\n* Bulky lesions (granular mixed with ≥10mm module).","ALL","18 Years",{"count":66,"type":67},752,"ESTIMATED","INTERVENTIONAL",[70],"NA","The goal of this clinical trial is to clarify the role of adjuvant thermal ablation for non-thermal endoscopic mucosal resection (EMR) of large (≥20mm) flat colorectal polyps (so-called laterally spreading lesions \\[LSLs\\]).\n\nThe hypothesis is that adding adjuvant thermal ablation to non-thermal EMR (vs no ablation) will result in lower lesion recurrence rates at 6-month follow-up, and non-inferior adverse events (AE) rates 14 days post EMR.\n\nFor participants with planned EMR, endoscopists will perform non-thermal EMRs as per standard of care and:\n\n* adjuvant thermal ablation will either not be performed (control group), or will be applied to the base and outside margins of the resection site (experimental group);\n* then, all patients will be contacted 14-44 days after EMR, to verbally ascertain the occurrence of AEs;\n* then, all patients will undergo a first follow-up colonoscopy at 6 months after initial conoloscopy to assess lesion recurrence;\n* finally, all patients will undergo a second and final colonoscopy 18 months after EMR.",[73,74],"Colorectal Cancer","Polyp of Colon","NOT_YET_RECRUITING","2025-11-17",{"date":78,"type":79},"2025-11-21","ACTUAL",{"date":81,"type":67},"2025-12",{"date":83,"type":67},"2032-05",{"name":5,"class":6},1]