[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556495":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":45,"responsibleParty":67,"collaborators":26,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":26,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":26,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":26,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Shaheed Zulfiqar Ali Bhutto Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"regenerative endodontic therapy with blood clot","ACTIVE_COMPARATOR","In the procedures of regenerative endodontics therapy, K-files were intentionally used to violate the periapical tissues via overinstrumentation up to 2-3mm past the apical foramen to induce bleeding. The adequate blood need to be full with canal space and below the CEJ, then wait for 10-15min to coagulate.",[13],"Procedure: blood clot",{"label":15,"type":16,"description":17,"interventionNames":18},"regenerative endodontic therapy with I-PRF","EXPERIMENTAL","In the procedures of regenerative endodontics therapy, K-files were intentionally used to violate the periapical tissues via overinstrumentation up to 2-3mm past the apical foramen to induce bleeding. Only the apex 1\u002F3 of the root canal need to be filled with blood. PRF was injected into the root canal to a level below the CEJ, then wait for 10-15min to coagulate.",[19],"Procedure: regenerative endodontic therapy using I-PRF",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","regenerative endodontic therapy using I-PRF","Blood will be taken from medial cubital vein",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"blood clot","Other: BC According to the procedures of regenerative endodontics therapy, BC was made by the way of provoking apical bleeding into root canal.",[9],[32],{"name":33,"affiliation":5,"role":34},"Dr Shahbaz Saqib, BDS","PRINCIPAL_INVESTIGATOR",[36,41],{"name":33,"role":37,"phone":38,"phoneExt":39,"email":40},"CONTACT","3092497829","+92","shahbazbds@outlook.com",{"name":42,"role":37,"phone":43,"phoneExt":39,"email":44},"Nasar Um Min Allah, BDS,MSD","3349586057","nz.zulfiqarali@gmail.com",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Dr Shahbaz Saqib","RECRUITING","Islamabad","ICT","44080","Pakistan","PK",{"type":55,"coordinates":56},"Point",[57,58],73.04329,33.72148,{"lat":58,"lon":57},[61,63,64],{"name":62,"role":37,"phone":38,"phoneExt":39,"email":40},"Shahbaz Saqib, BDS",{"name":33,"role":34,"phone":26,"phoneExt":26,"email":26},{"name":65,"role":66,"phone":26,"phoneExt":26,"email":26},"Dr Nasar Um Min Allah, Bds,Msd","SUB_INVESTIGATOR",{"type":34,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Shahbaz Saqib","Doctor","100556495","regenerative-endodontic-therapy-in-cases-of-irreversible-pulpitis-100556495",false,"NCT06525844","Regenerative Endodontic Therapy in Cases of Irreversible Pulpitis","Clinical and Radiographic Outcomes With the Use of I-PRF in Mature Permanent Teeth With Symptomatic Irreversible Pulpitis : A Randomized Control Trial","Inclusion Criteria:\n\n* Patients from both genders with an age range of 18-35 years old.\n* Permanent teeth with mature roots with a diagnosis of irreversible pulpitis, with absorption damage to the apex, and the diameter of the apical hole is greater than 1 mm.\n* A restorable tooth.\n* There is no need to leave space for the final post\u002Fcore restoration.\n* Anterior teeth and premolars with single canal.\n* A cooperative and compliant patient.\n* Patients not allergic to the drugs and antibiotics which needed to complete treatment.\n* No periodontal disease or root cracking.\n\nExclusion Criteria:\n\n* Patients with other serious organ diseases, such as cardiopulmonary, kidney and other major diseases.\n* Pregnant women or lactating or expecting within a year.\n* Patients with apical cysts.\n* Patients with poor cooperation and those who quit the study halfway.\n* Patients with periodontitis.\n* Patients with dental dysplasia or other oral genetic disorders.\n* Patients with dental phobia.\n* Patients with mental disorders.","ALL","18 Years","35 Years",{"count":81,"type":82},60,"ESTIMATED","INTERVENTIONAL",[85],"NA","Root canal therapy (RCT) is a classical and effective treatment that is currently utilised in dental practice, offering high success rates for pulp and periapical diseases; however, teeth after RCT are susceptible to altered pulp defence and sensory function, even fractures, as a consequence of pulp loss. Furthermore, several studies have highlighted that the actual failure rate of standard root canal treatments performed in general practice is significantly higher than expected . Moreover, these treatments are lengthy and costly and are often subject to retreatment .Inherent in this procedure(rct) is loss of dental hard tissue and subsequent weakening of the treated tooth,making them more prone to fracture. Therefore, less invasive alternative strategies could be used to treat pulpitis, even when irreversible.\n\nMurray et al. proposed the term \"Regenerative endodontic treatment (RET)\" in 2007, based on a tissue engineering concept (stem cells, biomimetic scaffolds, and bioactive growth factors). The 2016 American Association of Endodontists (AAE) guidelines formally defined RET as a collection of \"biologically based procedures designed to replace damaged tooth structures, including dentine and root structures, as well as cells of the pulp-dentine complex\"",[88],"Symptomatic Irreversible Pulpitis","2024-08-01",{"date":91,"type":92},"2024-08-05","ACTUAL",{"date":89,"type":92},{"date":95,"type":82},"2025-10-01",{"name":5,"class":6},1]