[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595423":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":37,"locations":31,"responsibleParty":46,"collaborators":48,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":31,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":31,"enrollmentInfo":62,"targetDuration":31,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":73,"whyStopped":31,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":31},{"fullName":5,"class":6},"Loma Linda University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Amnion Chorion Membrane","EXPERIMENTAL","Participants in this group will undergo guided bone regeneration for peri-implantitis using an amnion-chorion membrane (ACM) as the barrier membrane during surgical treatment.",[13],"Device: BioXclude Amnion Chorion Membrane",{"label":15,"type":16,"description":17,"interventionNames":18},"Collagen Membrane","ACTIVE_COMPARATOR","Participants in this group will undergo guided bone regeneration for peri-implantitis using a conventional collagen membrane as the barrier membrane during surgical treatment.",[19],"Device: Collagen Membrane",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","BioXclude Amnion Chorion Membrane","A resorbable allograft membrane derived from dehydrated human amnion and chorion tissue. The membrane is placed over peri-implant bony defects during guided bone regeneration to act as a biological barrier and promote tissue healing.",[9],[9,27],"ACM",{"type":22,"name":15,"description":29,"armGroupLabels":30,"otherNames":31},"A resorbable xenograft membrane derived from porcine collagen. The membrane is placed over peri-implant bony defects during guided bone regeneration to support space maintenance and facilitate bone regeneration.",[15],null,[33],{"name":34,"affiliation":35,"role":36},"Jaime Lozada","Department Chair","PRINCIPAL_INVESTIGATOR",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":31,"email":42},"Brandon Kim","CONTACT","805-305-0826","Bykim1@students.llu.edu",{"name":34,"role":40,"phone":44,"phoneExt":31,"email":45},"909-558-4980","JLozada@llu.edu",{"type":47,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR",[49],{"name":50,"class":51},"Maxxeus","UNKNOWN","100595423","regenerative-outcomes-for-peri-implant-bony-defects-using-amnion-chorion-barrier-vs-collagen-membrane-100595423",false,"NCT07032259","Regenerative Outcomes for Peri-implant Bony Defects Using Amnion-chorion Barrier vs. Collagen Membrane","Regenerative Outcomes for Peri-implant Bony Defects Using Amnion-chorion Barrier vs. Collagen Membrane: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Systemically healthy adults (≥18 years) with a diagnosed peri-implantitis lesion requiring surgical intervention of any ethnicity\n* Comprehension of treatment plan and research project.\n* Presence of a single implant in function for at least one year.\n* Radiographic evidence of peri-implant bone loss not exceeding one-third of the implant length.\n* 2-3 wall defects amenable to guided bone regeneration (GBR).\n* Screw-retained, posterior, self-cleansing implant prosthesis.\n* Commitment to maintaining oral hygiene and attending follow-up visits.\n\nExclusion Criteria:\n\n* Patients who have had a history of periodontitis, diabetes, smoking habit, or have been prescribed medications that may interfere with bone healing and metabolism\n* Patients with allergies to any treatment devices\n* Patients who have a lack of keratinized mucosa (\\\u003C2 mm), or positioning for implants or restorative designs that compromise oral hygiene\n* Peri-implant bone defects not attributable to peri-implantitis (e.g. surgical iatrogenic, trauma)\n* Anterior implant restorations (#'s 6-11, #'s 22-27) or cement-retained restorations",true,"ALL","18 Years",{"count":63,"type":64},56,"ESTIMATED","INTERVENTIONAL",[67],"NA","The purpose of this study is to compare the clinical and radiographic outcomes of two different barrier membranes-amnion-chorion membranes (ACM) and conventional collagen membranes-used in guided bone regeneration (GBR) procedures for the treatment of peri-implantitis. Both membranes are commonly used in clinical practice; however, this study aims to determine whether ACM offers greater benefits in terms of peri-implant probing depth reduction, radiographic bone fill, and patient-reported post-operative healing outcomes. The findings may help inform surgical decision-making and support the use of ACM as a more effective regenerative material for managing peri-implant bony defects.",[70],"Peri-Implantitis",[72],"Peri-implantitis","NOT_YET_RECRUITING","2026-01-28",{"date":76,"type":77},"2026-01-30","ACTUAL",{"date":79,"type":64},"2026-05",{"date":81,"type":64},"2027-07-01",{"name":5,"class":6}]