[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100583471":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":22,"responsibleParty":42,"collaborators":7,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":47,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":7,"studyType":59,"phases":7,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":36,"whyStopped":7,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Zhongda Hospital","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Gao-jun Teng, M.D","Zhongda hospital, Southeast university, Nanjing, China","PRINCIPAL_INVESTIGATOR",[14,19],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Gao-Jun Teng, M.D","CONTACT","+86-02583272121","gjteng@vip.sina.com",{"name":20,"role":16,"phone":17,"phoneExt":7,"email":21},"Hai-dong Zhu, M.D","zhuhaidong9509@163.com",[23,35],{"facility":5,"status":24,"city":25,"state":26,"zip":7,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":7},"COMPLETED","Nanjing","Jiangsu","China","CN",{"type":30,"coordinates":31},"Point",[32,33],118.77778,32.06167,{"lat":33,"lon":32},{"facility":5,"status":36,"city":25,"state":26,"zip":7,"country":27,"countryCode":28,"cosmosGeoPoint":37,"geoPoint":39,"contacts":40},"RECRUITING",{"type":30,"coordinates":38},[32,33],{"lat":33,"lon":32},[41],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},{"type":12,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Gao-jun Teng","President","100583471","regional-lymph-node-metastasis-and-survival-outcomes-in-advanced-hcc-100583471",false,"NCT06876753","Regional Lymph Node Metastasis and Survival Outcomes in Advanced HCC","Regional Lymph Node Metastasis and Survival Outcomes in Advanced Hepatocellular Carcinoma Receiving Transarterial Chemoembolization and PD-(L)1 Inhibitors-based Immunotherapy","CHANCE2421","Inclusion Criteria:\n\n1. Has a diagnosis of HCC confirmed by radiology, histology, or cytology;\n2. Barcelona Clinic Liver Cancer (BCLC) stage C with the presence of extrahepatic spread;\n3. Has not received any previous systemic therapy for HCC (including chemotherapy, molecularly targeted therapy, immunotherapy);\n4. Both PD-1\u002FPD-L1 inhibitors and anti-angiogenesis drugs patients received only include marketed drugs but are not limited to HCC approval;\n5. TACE was performed after the first PD-1\u002FPD-L1 inhibitor\u002Fanti-angiogenic drug treatment or before treatment (within 3 months);\n6. Received at least 1 cycle of PD-1\u002FPD-L1 inhibitor\u002Fanti-angiogenic drug combination therapy after TACE treatment;\n7. Has repeated measurable intrahepatic lesions;\n\nExclusion Criteria:\n\n1. Cholangiocarcinoma, fibrolamellar, sarcomatoid hepatocellular carcinoma, and mixed hepatocellular\u002Fcholangiocarcinoma subtypes(confirmed by histology, or pathology) are not eligible;\n2. Unable to meet criteria of combination timeframe described above;\n3. Child-Pugh C or PS \\> 2 or Severe hepatic encephalopathy","ALL","18 Years","80 Years",{"count":57,"type":58},300,"ESTIMATED","OBSERVATIONAL","Tumor-draining lymph nodes play an important role in anti-tumor immune responses. In patients with hepatocellular carcinoma (HCC), however, the relationship between regional lymph node metastasis (LNM) and immunotherapy-based efficacy is unclear. This study aimed to evaluate whether extrahepatic LNM is associated with worse survival outcomes as compared to other metastatic sites in patients with advanced HCC.",[62],"Hepatocellular Carcinoma (HCC)",[64,65,66,67,68],"hepatocellular carcinoma","lymph node metastasis","transarterial chemoembolization","immune checkpoint inhibitors","molecular target therapies","2025-03-10",{"date":71,"type":72},"2025-03-14","ACTUAL",{"date":74,"type":72},"2018-06-01",{"date":76,"type":58},"2025-07-01",{"name":5,"class":6},2]