[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100406450":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":22,"centralContacts":36,"locations":45,"responsibleParty":75,"collaborators":77,"id":148,"slug":149,"hasResults":150,"nctId":151,"briefTitle":152,"officialTitle":152,"acronym":153,"eligibilityCriteria":154,"healthyVolunteers":150,"sex":155,"minAge":156,"maxAge":157,"enrollmentInfo":158,"targetDuration":161,"studyType":162,"phases":10,"briefSummary":163,"conditions":164,"keywords":166,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":186},{"fullName":5,"class":6},"Beijing Tiantan Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"experimental group",null,"Ruptured AVMs:\n\n1. AVMs not involved vital eloquent areas, or more than 5 mm away from functional fiber bundles, microsurgery or hybrid surgery can be performed;\n2. Targeted embolization for hemorrhagic predictors could be considered as a monotherapy; embolization can be used as an adjunctive strategy to reduce flow or volume before microsurgery or stereotactic radiosurgery (SRS).\n3. SRS for patients with a volume less than 10ml and not in the acute phase(\\\u003C 3months) of hemorrhage. Volume-stage or dose-stage can be used for giant AVMs involving important eloquent areas.\n4. Conservation can be used for AVMs that are prone to severe disability due to intervention.\n\nUnruptured AVMs:\n\nInterventions are recommended if unruptured AVMs are assessed as being at high rupture risk, or have refractory epilepsy or acceptable postoperative neurological deficits, otherwise conservative treatment is recommended. The choice of intervention strategy was the same as for ruptured AVM.",[13],"Other: Multi-disciplinary assessment",{"label":15,"type":10,"description":16,"interventionNames":10},"control group","Patients who had not received a multidisciplinary assessment to develop a treatment plan were included in the control group. It should be noted that the multidisciplinary team for AVM was formed in June 2018, so the prospective AVM cohort from August 2011 to June 2018 and the AVM cohort after June 2018 without comprehensive evaluation of treatment regimens by the multidisciplinary team served as the control group.",[18],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"Multi-disciplinary assessment","1. Comprehensive evaluation by multidisciplinary experts;\n2. Preoperative multi-modal imaging examination was applied to determine the angioarchitecture, functional fiber bundle, and hemodynamics.",[9],[23,26,30,32,34],{"name":24,"affiliation":5,"role":25},"Wang Shuo, MD","STUDY_CHAIR",{"name":27,"affiliation":28,"role":29},"Li Youxiang, MD","Beijing Neurosurgical Institute","PRINCIPAL_INVESTIGATOR",{"name":31,"affiliation":28,"role":29},"Liu Ali, MD",{"name":33,"affiliation":28,"role":29},"Zhao Yuanli, MD",{"name":35,"affiliation":28,"role":29},"Chen Xiaolin, MD",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},"Chen Yu, MD","CONTACT","+8618801239327","chenyu_tiantan@126.com",{"name":35,"role":39,"phone":43,"phoneExt":10,"email":44},"+8613810624845","xiaolinchen488@hotmail.com",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Capital medical university affiliated Beijing Tiantan hospital","RECRUITING","Beijing","Beijing Municipality","101100","China","CN",{"type":55,"coordinates":56},"Point",[57,58],116.39723,39.9075,{"lat":58,"lon":57},[61,65,66,68,69,71,73],{"name":62,"role":39,"phone":63,"phoneExt":10,"email":64},"Jin Hengwei, MD","+8615001189679","jinhengwei1987@163.com",{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},{"name":67,"role":29,"phone":10,"phoneExt":10,"email":10},"Meng Xiangyu, MD",{"name":38,"role":29,"phone":10,"phoneExt":10,"email":10},{"name":70,"role":29,"phone":10,"phoneExt":10,"email":10},"Li Ruinan, MD",{"name":72,"role":29,"phone":10,"phoneExt":10,"email":10},"Han Heze, MD",{"name":74,"role":29,"phone":10,"phoneExt":10,"email":10},"Li Zhipeng, MD",{"type":76,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[78,79,81,83,85,87,89,92,94,96,98,100,102,104,106,108,110,112,114,116,118,120,122,124,126,128,130,132,134,136,138,140,142,144,146],{"name":28,"class":6},{"name":80,"class":6},"Peking University International Hospital",{"name":82,"class":6},"West China Hospital",{"name":84,"class":6},"First Affiliated Hospital of Harbin Medical University",{"name":86,"class":6},"Sichuan Provincial People's Hospital",{"name":88,"class":6},"The First Hospital of Jilin University",{"name":90,"class":91},"Shanxi Provincial People's Hospital","OTHER_GOV",{"name":93,"class":6},"The Second Hospital of Shandong University",{"name":95,"class":6},"The First Affiliated Hospital of Zhengzhou University",{"name":97,"class":6},"First Affiliated Hospital of Xinjiang Medical University",{"name":99,"class":6},"The General Hospital of Central Theater Command",{"name":101,"class":6},"The Affiliated Hospital Of Guizhou Medical University",{"name":103,"class":6},"First Affiliated Hospital of Guangxi Medical University",{"name":105,"class":6},"Tianjin Medical University Second Hospital",{"name":107,"class":6},"The First Affiliated Hospital of Shanxi Medical University",{"name":109,"class":6},"Shengjing Hospital",{"name":111,"class":6},"Second Affiliated Hospital of Guangzhou Medical University",{"name":113,"class":6},"Hainan People's Hospital",{"name":115,"class":6},"The Second Affiliated Hospital of Kunming Medical University",{"name":117,"class":6},"The Affiliated Hospital of Qingdao University",{"name":119,"class":6},"Second Xiangya Hospital of Central South University",{"name":121,"class":6},"Second Affiliated Hospital of Soochow University",{"name":123,"class":6},"General Hospital of Ningxia Medical University",{"name":125,"class":6},"Lanzhou University Second Hospital",{"name":127,"class":6},"The First Affiliated Hospital of Anhui Medical University",{"name":129,"class":6},"First Affiliated Hospital of Zhejiang University",{"name":131,"class":6},"Qilu Hospital of Shandong University",{"name":133,"class":6},"Jining Medical University",{"name":135,"class":6},"First Affiliated Hospital of Chongqing Medical University",{"name":137,"class":6},"First Affiliated Hospital of Fujian Medical University",{"name":139,"class":91},"Shandong Provincial Hospital",{"name":141,"class":6},"The Affiliated Hospital of Xuzhou Medical University",{"name":143,"class":6},"Henan Provincial People's Hospital",{"name":145,"class":6},"Binzhou Medical University",{"name":147,"class":6},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","100406450","registry-of-multimodality-treatment-for-brain-arteriovenous-malformation-in-mainland-china-100406450",false,"NCT04572568","Registry of Multimodality Treatment for Brain Arteriovenous Malformation in Mainland China","MATCH","Inclusion Criteria:\n\n1. The diagnosis of AVM was confirmed with digital subtraction angiography (DSA) and\u002For magnetic resonance imaging(MRI).\n2. Patients with complete clinical and imaging data.\n3. Patient or patient's legal representative agreed to collection of information for this study and signed informed consent.\n\nExclusion Criteria:\n\n1. Received other treatment (surgery, embolization or SRS)before inclusion;\n2. Expected survival time is less than 6 months;\n3. Spinal AVMs;\n4. Patients missing critical baseline and imaging data.","ALL","1 Year","80 Years",{"count":159,"type":160},2000,"ESTIMATED","3 Years","OBSERVATIONAL","This study is a multi-center, prospective, registry study. This research was supported by the National Key Research and Development Program. They were divided into experimental group and control group according to whether the treatment plan was formulated by a multidisciplinary team. Patients of experimental group is strictly in accordance with standardized multi-disciplinary treatment protocols and meet the following criteria: 1. A multi-disciplinary conference discussion; 2. Detailed preoperative evaluation based on CT, MRI, fMRI and DSA. 3. Treatment modalities meet the following treatment criteria（craniotomy, embolization and stereotactic radiosurgery）. The control group was patients who had not been treated according to a multi-disciplinary treatment protocol.\n\nPatient baseline data, AVM angioarchitectural features, imaging DICOM data, surgical information, and follow-up information were registered. All patients were evaluated for neurofunction at baseline, 3 months, 12 months, and 3 years after treatment. Main observation endpoints: 1. Modified Rankin Scale; 2. Obliteration rate; 3. Subsequent hemorrhage; 4. Complication rate (such as morbidity rate, new-onset neurological dysfunction, and radiation-related complications). Secondary observation endpoint: improvement of clinical symptoms (epilepsy, headache, neurological dysfunction) at 3 months, 12 months, and 3 years after treatment.",[165],"Brain Arteriovenous Malformation",[165,167,168,169,170,171,172,173,174,175,176],"multi-disciplinary treatment","embolization","stereotactic radiosurgery","microsurgical resection","hybrid surgery","conservative\u002Fmedical treatment","hemodynamic","outcomes","subsequent hemorrhage","obliteration","2022-05-17",{"date":179,"type":180},"2022-05-23","ACTUAL",{"date":182,"type":180},"2011-08-01",{"date":184,"type":160},"2033-04-01",{"name":5,"class":6},1]