[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100527409":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":26,"responsibleParty":41,"collaborators":10,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":47,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":58,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":10,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"General University Hospital, Prague","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"CIN 2, CIN 3",null,"Bioptically verified CIN 2 or CIN 3 lesion",[13],"Diagnostic Test: Colposcopy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Colposcopy","No surgery, observation",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Lukas Dostalek","CONTACT","+420224967451","lukas.dostalek@vfn.cz",[27],{"facility":28,"status":29,"city":30,"state":10,"zip":31,"country":32,"countryCode":10,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"General University Hospital","RECRUITING","Prague","12800","Czechia",{"type":34,"coordinates":35},"Point",[36,37],14.42076,50.08804,{"lat":37,"lon":36},[40],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","David Cibula","Dr, PhD","100527409","regression-of-cervical-precancerous-lesions-and-associated-risk-factors-100527409",false,"NCT06147388","Regression of Cervical Precancerous Lesions and Associated Risk Factors","RECER","Inclusion Criteria:\n\n1. squamocolumnar junction fully visualized\n2. bioptically verified CIN 2 or CIN 3\n3. age ≥ 18 years\n4. age ≤ 40 years\n5. informed consent\n\nExclusion Criteria:\n\n1. squamocolumnar junction not fully visualized\n2. suspicion on glandular lesion\n3. suspicion on invasive cancer\n4. personal history of CIN 2, 3 or cerv. cancer\n5. gravidity\n6. HIV positivity\n7. immunosuppression\n8. impossible photographic documentation","FEMALE","18 Years","40 Years",{"count":56,"type":57},300,"ESTIMATED","2 Years","OBSERVATIONAL","The aim of this study is to assess the extent of histopathological regression of severe cervical precancerous lesions (CIN 2 and CIN 3); evaluate the proportion of patients who experience the normalization of HPV test and cytology finding among those who were treated conservatively and those who underwent conization; and identify predictive parameters associated with regression. Based on this analysis, a model will be proposed to predict the likelihood of lesion regression.",[62,63,64,65],"Cervix Uteri SIL","HPV","CIN2","CIN3","2026-02-22",{"date":68,"type":69},"2026-02-25","ACTUAL",{"date":71,"type":69},"2022-09-01",{"date":73,"type":57},"2027-07-01",{"name":5,"class":6},1]