[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595737":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":19,"centralContacts":19,"locations":29,"responsibleParty":63,"collaborators":67,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":87,"sex":92,"minAge":93,"maxAge":19,"enrollmentInfo":94,"targetDuration":19,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":103,"overallStatus":32,"whyStopped":19,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Wageningen University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","EXPERIMENTAL","The intervention group receives a tailor-made protein-enriched diet and an extended progressive resistance training program.",[13,14],"Other: Protein-enriched diet","Other: Progressive resistance exercise",{"label":16,"type":17,"description":18,"interventionNames":19},"Control","NO_INTERVENTION","The control group receives usual care.",null,[21,25],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":19},"Protein-enriched diet","A protein intake of 1.5 g\u002Fkg bodyweight\u002Fday. This will be obtained by consuming protein-rich and protein-enriched foods.",[9],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":19},"Progressive resistance exercise","The intervention group will perform resistance training during three non-consecutive days with a minimum of 48 hours between the sessions. Subjects will continue the resistance training after discharge for 2 times a week, also with a minimum of 48 hours between sessions until the study period of 3 months is completed. All sessions will be supervised by physiotherapists.",[9],[30,49],{"facility":31,"status":32,"city":33,"state":19,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Rijnstate Hospital","RECRUITING","Arnhem","6851AD","Netherlands","NL",{"type":38,"coordinates":39},"Point",[40,41],5.91111,51.98,{"lat":41,"lon":40},[44],{"name":45,"role":46,"phone":47,"phoneExt":19,"email":48},"Hugo H Wijnen, MD","CONTACT","0031 88 005 7397","hwijnen@rijnstate.nl",{"facility":50,"status":32,"city":51,"state":19,"zip":52,"country":35,"countryCode":36,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"Gelderse Vallei Hospital","Ede","6716RP",{"type":38,"coordinates":54},[55,56],5.65833,52.03333,{"lat":56,"lon":55},[59],{"name":60,"role":46,"phone":61,"phoneExt":19,"email":62},"Nienke Golüke, MD","0031 318 43 5938","ngoluke@zgv.nl",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"PRINCIPAL_INVESTIGATOR","Lisette de Groot","prof.dr.ir.",[68,69,70,72,75,77,79,81,83],{"name":31,"class":6},{"name":50,"class":6},{"name":71,"class":6},"HAN University of Applied Sciences",{"name":73,"class":74},"Liemerije Revalidatiezorg","UNKNOWN",{"name":76,"class":74},"Opella Revalidatiezorg",{"name":78,"class":74},"Pleyade Revalidatiezorg",{"name":80,"class":74},"Attent Zorg en Behandeling",{"name":82,"class":74},"Alliantie Voeding in de Zorg",{"name":84,"class":74},"Osteoporosis Association","100595737","rehabilitation-after-a-hip-fracture-the-effects-of-dietary-protein-and-exercise-on-bone-and-muscle-health-and-quality-of-life-100595737",false,"NCT07036341","Rehabilitation After a Hip Fracture: the Effects of Dietary Protein and Exercise on Bone and Muscle Health and Quality of Life","ProBUS","In order to be eligible to participate in this study, a subject must meet all of the following criteria:\n\n* Age ≥ 65 years\n* Acute hip fracture\n* Able to give written informed consent\n* Mentally competent, as judged by the treating physician\n* Admission to a rehabilitation centre that participates in this research\n\nA potential subject who meets any of the following criteria will be excluded from participation in this study:\n\n* Allergic, intolerant or hypersensitive to milk\u002Flactose (self-reported)\n* Not willing to stop using dietary supplements with exception of calcium and vitamin D\n* Pathological fracture or periprosthetic fracture\n* Abnormal hepatic or renal laboratory parameters, such as estimated glomerular filtration rate (eGFR) \\\u003C30 ml\u002Fmin\u002F1,73 m2 (data from hospital)\n* Diagnosis of disorders\u002Fdiseases where a high protein intake can be harmful, such as renal impairment or failure, or liver disease (geriatric care physician has the decisive voice)\n* Diagnosis of bone metabolic disorders such as primary hyperparathyroidism, Paget's disease, or myeloma.\n* Taking medication other than bisphosphonates known to strongly alter bone, calcium or muscle metabolism, such as oestrogen, hormone replacement therapy, corticosteroids, anabolic agents, or calcitonin.\n* Disorders\u002Fdiseases which may affect ability to follow study protocol and which cannot be overcome with help of a caregiver\n* Current participation in other scientific research\n* No permission to request information from the general practitioner\u002F treating specialist(s) about medical history, medication use, liver and kidney values, and details about the broken hip","ALL","65 Years",{"count":95,"type":96},102,"ESTIMATED","INTERVENTIONAL",[99],"NA","Hip fractures often lead to functional limitations, loss of independence, weight loss and decreased well-being. Only half of the patients regain their functional level and 24% die within the following year. Financial consequences are significant due to costly surgery and long-term care. Hip fracture incidence is expected to increase sharply due to the ageing population, reducing accessibility to and quality of rehabilitation care. Therefore, optimizing treatment is essential.\n\nPrevious protein and exercise studies showed improved muscle and bone health in healthy or frail community-dwelling older adults, but effects in older hip fracture patients are not known. Better rehabilitation may improve bone and muscle health, nutritional status, quality of life, lower costs and lower burden for healthcare.\n\nThe overall objective is to investigate the effectiveness, costs and cost-effectiveness of a protein-enriched diet and resistance exercise for 3 months compared to usual care on bone and muscle health, and quality of life in older adults recovering from an acute hip fracture.",[102],"Hip Fractures",[104,105,106,107,108],"Hip fracture patients","Protein","Resistance Exercise","Bone health","Muscle health","2025-06-23",{"date":111,"type":112},"2025-06-25","ACTUAL",{"date":114,"type":112},"2024-09-01",{"date":116,"type":96},"2026-08",{"name":5,"class":6},2]