[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100358547":3},{"organization":4,"armGroups":7,"interventions":36,"overallOfficials":55,"centralContacts":59,"locations":64,"responsibleParty":84,"collaborators":86,"id":91,"slug":92,"hasResults":93,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":28,"eligibilityCriteria":96,"healthyVolunteers":93,"sex":97,"minAge":98,"maxAge":28,"enrollmentInfo":99,"targetDuration":28,"studyType":102,"phases":103,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":66,"whyStopped":28,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"University of California, San Francisco","OTHER",[8,13,19,24,29,31],{"label":9,"type":6,"description":10,"interventionNames":11},"Arm 1 Cohort 1: Interventional arm\u002FIn-person rehab (CLOSED)","The in-person cognitive rehabilitation will focus on the application of evidenced based strategies recommended as practice guidelines by the American Congress of Rehabilitation Medicine Cognitive Rehabilitation Task Force (ACRM-CR). The treatment occurs in two stages 1) comprehensive neuropsychological assessment and rehabilitation planning and 2) implementation of treatment planning.\n\nn = 20 patients",[12],"Behavioral: In-person cognitive rehabilitation",{"label":14,"type":15,"description":16,"interventionNames":17},"Arm 1 Cohort 2: Interventional arm\u002FReMind iPad app (CLOSED)","EXPERIMENTAL","The ReMind iPad-based cognitive rehabilitation was developed with collaborators at Tilburg University, The Netherlands, and is an evidence-based program to improve attention and memory through (1) cognitive training and (2) teaching compensatory skills in patients with brain tumors. Brain plasticity-based computerized cognitive training is a newly developing field of therapeutics for neurological and psychiatric disorders that uses frequent game-like training sessions to drive improvements in cognitive functions.\n\nn = 20 patients",[18],"Device: ReMind iPad app",{"label":20,"type":15,"description":21,"interventionNames":22},"Arm 1 Cohort 3: Interventional arm\u002FHealthy SMS texting (CLOSED)","The mobile phone texting intervention was developed with collaborators at Zuckerberg San Francisco General Hospital and is currently being studied in individuals with depression and traumatic brain injury. Participants receive a daily message sent at a random time (within their chosen timeframe(s); e.g. 9am-9pm). Messages will focus on patient-based education-focused health-related quality of life and cognitive education such as internal and external cognitive compensatory strategy training, fatigue management, and coping skills.\n\nn = 20 patients",[23],"Device: Healthy SMS texting",{"label":25,"type":26,"description":27,"interventionNames":28},"Arm 2 Cohort 4: Longitudinal arm\u002FUpfront radiation","NO_INTERVENTION","Patients will undergo longitudinal global cognitive and HRQOL assessments at baseline prior to surgery, after surgery, 3 months after surgery and every 6 months for 3 years. Clinical data will be collected at the time of each assessment. This will include changes in serial imaging e.g. in T2 tumor volume, DTI scalar quantification, resting-state fMRI connectivity n = 50 patients",null,{"label":30,"type":26,"description":27,"interventionNames":28},"Arm 1 Cohort 5: Longitudinal arm\u002FNo upfront radiation",{"label":32,"type":6,"description":33,"interventionNames":34},"Arm 1 Cohort 1A: Telehealth Cognitive Rehabilitation","The telehealth cognitive rehabilitation will take place over secure UCSF Zoom. It will focus on the application of evidenced based strategies recommended as practice guidelines by the American Congress of Rehabilitation Medicine Cognitive Rehabilitation Task Force (ACRM-CR). The treatment occurs in two stages 1) comprehensive neuropsychological assessment and rehabilitation planning and 2) implementation of treatment planning. During treatment implementation, patients acquire, apply, and adapt evidenced based strategies based on neuropsychological testing and conjointly developed treatment planning goals.\n\nN=20",[35],"Behavioral: Telehealth cognitive rehabilitation",[37,42,46,51],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":28},"DEVICE","ReMind iPad app","Evidence-based program to improve attention and memory through (1) cognitive training and (2) teaching compensatory skills in patients with brain tumors.",[14],{"type":38,"name":43,"description":44,"armGroupLabels":45,"otherNames":28},"Healthy SMS texting","Participants receive a daily message sent at a random time (within their chosen timeframe(s); e.g. 9am-9pm). Messages will focus on patient-based education-focused health-related quality of life and cognitive education such as internal and external cognitive compensatory strategy training, fatigue management, and coping skills.",[20],{"type":47,"name":48,"description":49,"armGroupLabels":50,"otherNames":28},"BEHAVIORAL","In-person cognitive rehabilitation","The in-person cognitive rehabilitation will focus on the application of evidenced based strategies recommended as practice guidelines by the American Congress of Rehabilitation Medicine Cognitive Rehabilitation Task Force (ACRM-CR). The treatment occurs in two stages 1) comprehensive neuropsychological assessment and rehabilitation planning and 2) implementation of treatment planning.",[9],{"type":47,"name":52,"description":53,"armGroupLabels":54,"otherNames":28},"Telehealth cognitive rehabilitation","The telehealth cognitive rehabilitation will take place over secure UCSF Zoom. It will focus on the application of evidenced based strategies recommended as practice guidelines by the American Congress of Rehabilitation Medicine Cognitive Rehabilitation Task Force (ACRM-CR). The treatment occurs in two stages 1) comprehensive neuropsychological assessment and rehabilitation planning and 2) implementation of treatment planning",[32],[56],{"name":57,"affiliation":5,"role":58},"Jennie Taylor, MD, MPH","PRINCIPAL_INVESTIGATOR",[60],{"name":57,"role":61,"phone":62,"phoneExt":28,"email":63},"CONTACT","415-353-2966","jennie.taylor@ucsf.edu",[65],{"facility":5,"status":66,"city":67,"state":68,"zip":69,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":77,"contacts":78},"RECRUITING","San Francisco","California","94143","United States","US",{"type":73,"coordinates":74},"Point",[75,76],-122.41942,37.77493,{"lat":76,"lon":75},[79,83],{"name":80,"role":61,"phone":81,"phoneExt":28,"email":82},"Jennie W Taylor, MD, MPH","877-827-3222","cancertrials@ucsf.edu",{"name":80,"role":58,"phone":28,"phoneExt":28,"email":28},{"type":85,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR",[87,89],{"name":88,"class":6},"Tilburg University",{"name":90,"class":6},"University of California, Berkeley","100358547","rehabilitation-and-longitudinal-follow-up-of-cognition-in-adult-lower-grade-gliomas-100358547",false,"NCT03948490","Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas","Arm 1:\n\nInclusion Criteria:\n\n* Histologically confirmed low grade supratentorial primary brain tumor\n* \\>= 18 years old\n* Life expectancy \\> 12 weeks\n* Karnofsky performance status (KPS) \\>= 70\n* Must speak and be able to read English fluently\n* Must have access to the internet\n* Must have text enabled cellphone\n* Must be receiving MRI scans at University of California, San Francisco (UCSF)\n* Must be clinically stable and off treatment (e.g. radiation or chemotherapy) for ≥ 3 months\n* Must be \\>= 6 months from craniotomy\n* Must have subjective complaints of cognitive deficits\n* Must have adequate seizure control and be on a stable, or decreasing, dose of anti-epileptics\n* Must score \\\u003C= 1 SD below normal on ≥ 2 or more domains of baseline neuropsychological assessments\n\nExclusion Criteria:\n\n* Diagnosis or evidence of any of the following:\n* • Glioblastoma\n* • Extra-axial disease (i.e. meningioma)\n* • Infra-tentorial disease\n* Are not able to comply with study and\u002For follow-up procedures\n* Are unable to complete or score \\>= 3 cognitive tests at baseline, which is indicative that patients would be unable to complete the cognitive rehabilitation interventions\n* Are acutely suicidal, psychotic, and\u002For gravely disabled.\n* Patients who, based on the neuropsychologist's opinion, are unable to participate in cognitive testing and\u002For cognitive rehab secondary to significant neurologic deficit\n\nArm 2:\n\nInclusion Criteria:\n\n* Have a presumed low grade primary brain tumor and either be undergoing definitive surgery or have had surgical resection within the last 4 months.\n* Prior surgery is allowed if they have not received additional tumor directed treatment.\n* \\>= 18 years old\n* Must speak and be able to read English fluently.\n* Plan to continue to care in neuro-oncology at UCSF\n* Must be receiving MRI scans.\n\nExclusion Criteria:\n\n* Diagnosis or evidence of any of the following:\n* • Glioblastoma\n* • Extra-axial disease (i.e. meningioma)\n* Are not able to comply with study and\u002For follow-up procedures\n* Have acute psychiatric issues (suicidality, active psychosis, gravely disabled)","ALL","18 Years",{"count":100,"type":101},97,"ESTIMATED","INTERVENTIONAL",[104],"NA","Patients with glial brain tumors have increasingly improved outcomes, with median survival of 5-15 years. However, the treatments, including surgery, radiation, and chemotherapy, often lead to impaired attention, working memory, and other cognitive functions. These cognitive deficits frequently have significant impact on patient quality of life. Although currently, there is no established standard of care to treat cognitive deficits in brain tumor patients, standard cognitive rehabilitative treatments have been developed for those with traumatic brain injury and stroke. However, the feasibility and efficacy of these cognitive treatments in individuals with brain tumors remains unclear.",[107],"Low-grade Glioma",[109,110],"cognitive impairment","quality of life","2026-06-02",{"date":113,"type":114},"2026-06-04","ACTUAL",{"date":116,"type":114},"2019-06-07",{"date":118,"type":101},"2027-03-31",{"name":5,"class":6},1]