[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100363828":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":21,"centralContacts":32,"locations":38,"responsibleParty":107,"collaborators":10,"id":111,"slug":112,"hasResults":113,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":113,"sex":119,"minAge":120,"maxAge":121,"enrollmentInfo":122,"targetDuration":125,"studyType":126,"phases":10,"briefSummary":127,"conditions":128,"keywords":131,"overallStatus":82,"whyStopped":10,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":145},{"fullName":5,"class":6},"Children's Hospital of Chongqing Medical University","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"depressive disorder group",null,"At 21 weeks of pregnancy, women diagnosed with depressive disorder by the Hamilton depression scale and Beck depression rating scale and their offspring were enrolled.",{"label":13,"type":10,"description":14,"interventionNames":10},"Nutrient-deficient group","Nutrients (Vitamin A,D,E) were tested at 21 weeks of pregnancy, and pregnant women with one or more nutrient deficiencies or insufficiency and their offspring were enrolled.",{"label":16,"type":10,"description":17,"interventionNames":10},"depressive disorder and nutrient deficiency group","At 21 weeks of pregnancy, pregnant women with depressive disorder and nutrient deficiency or insufficiency and their offspring were enrolled.",{"label":19,"type":10,"description":20,"interventionNames":10},"Neither group","At 21 weeks of pregnancy, pregnant women without depressive disorder and nutrient deficiency or insufficiency and their offspring were enrolled.",[22,25,29],{"name":23,"affiliation":5,"role":24},"Li Chen, MD","STUDY_DIRECTOR",{"name":26,"affiliation":27,"role":28},"Tanya Froehlich, MD,MS","Children's Hospital Medical Center, Cincinnati","PRINCIPAL_INVESTIGATOR",{"name":30,"affiliation":5,"role":31},"yu T Li, MS","STUDY_CHAIR",[33],{"name":23,"role":34,"phone":35,"phoneExt":36,"email":37},"CONTACT","(+86)136 7762 0103","+86","chenli2012@126.com",[39,58,69,80,92],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"The People's Hospital of Yubei District of Chongqing City","NOT_YET_RECRUITING","Chongqing","Chongqing Municipality","401120","China","CN",{"type":48,"coordinates":49},"Point",[50,51],106.55771,29.56026,{"lat":51,"lon":50},[54],{"name":55,"role":34,"phone":56,"phoneExt":36,"email":57},"chun Y Su, MD","(+86)189 9613 7157","1501614339@qq.com",{"facility":59,"status":41,"city":42,"state":43,"zip":60,"country":45,"countryCode":46,"cosmosGeoPoint":61,"geoPoint":63,"contacts":64},"Chongqing First People's Hospital of Liangjiang New Area","401121",{"type":48,"coordinates":62},[50,51],{"lat":51,"lon":50},[65],{"name":66,"role":34,"phone":67,"phoneExt":36,"email":68},"Chao Li, MB","(+86)13896164470","695040138@qq.com",{"facility":70,"status":41,"city":42,"state":43,"zip":71,"country":45,"countryCode":46,"cosmosGeoPoint":72,"geoPoint":74,"contacts":75},"The Central Hospital of Jiangjin District of Chongqing City","402260",{"type":48,"coordinates":73},[50,51],{"lat":51,"lon":50},[76],{"name":77,"role":34,"phone":78,"phoneExt":36,"email":79},"Feng Li, Master","(+86)136 6801 9599","123495256@qq.com",{"facility":81,"status":82,"city":42,"state":43,"zip":83,"country":45,"countryCode":46,"cosmosGeoPoint":84,"geoPoint":86,"contacts":87},"Wanzhou Health Center for Women and Children","RECRUITING","404100",{"type":48,"coordinates":85},[50,51],{"lat":51,"lon":50},[88],{"name":89,"role":34,"phone":90,"phoneExt":36,"email":91},"zhi W Shen, Master","(+86)137 0945 8848","13709458848@126.com",{"facility":93,"status":41,"city":94,"state":95,"zip":96,"country":45,"countryCode":46,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"The Maternal and Child Health Hospital of Hainan Province","Haikou","Hainan","570000",{"type":48,"coordinates":98},[99,100],110.34651,20.03421,{"lat":100,"lon":99},[103],{"name":104,"role":34,"phone":105,"phoneExt":36,"email":106},"Ling Li, Master","(+86)186 8985 3985","liling53985@126.com",{"type":108,"investigatorFullName":109,"investigatorTitle":110,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Chen Li","Vice Director, Professor","100363828","relationship-about-pregnancy-health-and-offspring-developmental-behavioral-outcomes-100363828",false,"NCT04017286","Relationship About Pregnancy Health and Offspring Developmental &Behavioral Outcomes","A Prospective Cohort Study of the Association Between Pregnancy Health and Offspring Developmental & Behavioral Outcomes(Multi-Centered)","APCSAHAODBO","Inclusion Criteria:\n\n1. Inclusion criteria for pregnant women: Aged 20\\~49;\n2. no cognitive impairment, able to complete the scale test;\n3. Hamilton Depression Scale (HAMD questionnaire) is normal (HAMD score \\\u003C8 points) or mild to moderate positive (HAMD questionnaire score: 8\\~35 points);\n4. Participants are asked for their own written informed content for the study;\n\nExclusion Criteria:\n\n1. Patients receiving anti-depression therapy during the first 6 months of gestation or during pregnancy;\n2. Patients with severe depression with scores of no less than 35 points in the HAMD questionnaire;\n3. Patients with other mental disorders;\n4. Patients with neurological diseases;\n5. Patients with cognitive dysfunction.","ALL","3 Months","72 Months",{"count":123,"type":124},3000,"ESTIMATED","6 Years","OBSERVATIONAL","This topic puts forward a hypothesis: genetic and environmental factors such as major depressive disorder during pregnancy, nutritional status of vitamin A, D, E, and folic acid, intestinal microecology, and bisphenol A exposure, may affect the cognitive development level of the offspring through the genetic correlation with attention deficit hyperactivity disorder, developmental delay\u002Fintellectual disability, and major depressive disorder, allelic heterogeneity and pleiotropy of ITIH3 mediated by SNP and CACNB2, neurotransmitters like dopamine, and metabolic pathways, thereby increasing the risk of attention deficit hyperactivity disorder and developmental delay\u002Fintellectual disability prevalence on offspring.\n\nThis topic planning from allelic heterogeneity and pleiotropy of attention deficit hyperactivity disorder and major depressive disorder mediated by SNP, neurotransmitters like dopamine, and metabolic pathways, explores deeply the influences on children's development level and the risk of common neurological disorder caused by genetic and environmental factors during pregnancy, looking for reasonable prevention, early diagnosis of biomarkers and therapeutic targets, in order to provide data support for further improvement and revision of national mother and infant healthcare policy .",[129,130],"Children Behavior Problem","Pregnancy",[132,133,134,135],"Developmental assessment","Homocysteine","physique growth","nutrients","2021-01-29",{"date":138,"type":139},"2021-02-01","ACTUAL",{"date":141,"type":139},"2019-07-01",{"date":143,"type":124},"2028-12-31",{"name":109,"class":6},5]