[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100534809":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":26,"locations":31,"responsibleParty":44,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":10,"enrollmentInfo":57,"targetDuration":60,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Samsung Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"HFrEF",null,"Patients with heart failure with reduced ejection fraction (HFrEF) without significant coronary artery disease (non-ischemic cardiomyopathy)",[13],"Diagnostic Test: CMD test",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIAGNOSTIC_TEST","CMD test","Measured CFR and IMR",[9],[21],"Coronary microvascular dysfunction",[23],{"name":24,"affiliation":5,"role":25},"Ki Hong Choi, MD","PRINCIPAL_INVESTIGATOR",[27],{"name":24,"role":28,"phone":29,"phoneExt":10,"email":30},"CONTACT","82-2-3410-3419","cardiokh@gmail.com",[32],{"facility":5,"status":33,"city":34,"state":10,"zip":10,"country":35,"countryCode":10,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Seoul","South Korea",{"type":37,"coordinates":38},"Point",[39,40],126.9784,37.566,{"lat":40,"lon":39},[43],{"name":24,"role":28,"phone":29,"phoneExt":10,"email":30},{"type":25,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Ki Hong Choi","Professor","100534809","relationship-between-coronary-microvascular-dysfunction-and-improvement-of-left-ventricular-systolic-function-in-patients-with-heart-failure-with-reduced-ejection-fraction-caused-by-non-ischemic-etiology-100534809",false,"NCT06243653","Relationship Between Coronary Microvascular Dysfunction and Improvement of Left Ventricular Systolic Function in Patients With Heart Failure With Reduced Ejection Fraction Caused by Non-ischemic Etiology","The Role of Coronary Microvascular Dysfunction in Improving Left Ventricular Systolic Function Using Registry for Evaluation of Factors associatEd With Heart Failure With Reduced Ejection Fraction Caused by Non-ischemic Etiology (REFERENCE).","HFrEF-CMD","Inclusion Criteria:\n\n* a) Subject must be at least 19 years of age. b) Subject with symptoms or signs of HF (NYHA ≥2 dyspnea) and reduced ejection fraction (LVEF ≤ 40%) c) Subject who clinically need coronary angiography d) Subject who can voluntarily sign informed consent form\n\nExclusion Criteria:\n\n* a) Subject with significant coronary artery stenosis on coronary angiography (diameter stenosis ≥90% or 50-90% with fractional flow reserve \\[FFR\\] ≤0.80) b) Subject scheduled for cardiac replacement therapy (heart transplantation or left ventricular assisted device \\[LVAD\\] implantation) c) HF due to restrictive cardiomyopathy, active myocarditis, or constrictive pericarditis d) Significant valvular heart disease requiring surgery e) Subject who have non-cardiac co-morbid conditions with life expectancy \\\u003C1 year","ALL","19 Years",{"count":58,"type":59},200,"ESTIMATED","1 Year","OBSERVATIONAL","This study aims to evaluate the incidence of coronary microvascular dysfunction (CMD) and its prognostic implication for the improvement of left ventricular function in patients who have been diagnosed with heart failure with reduced ejection fraction (HFrEF) caused by non-ischemic etiology.",[64,65,66],"Heart Failure","Microvascular Angina","Non-ischemic Cardiomyopathy",[68,69],"coronary microvascular dysfunction","non-ischemic cardiomyopathy","2024-02-05",{"date":72,"type":73},"2024-02-06","ACTUAL",{"date":75,"type":73},"2023-08-09",{"date":77,"type":59},"2027-12-31",{"name":5,"class":6},1]