[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602763":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":21,"locations":27,"responsibleParty":45,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":62,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":73,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Recep Tayyip Erdogan University Training and Research Hospital","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with normal or minor malocclusion",null,"Patients with a Dental Aesthetic Index Score of ≤25",{"label":13,"type":10,"description":14,"interventionNames":10},"Moderate malocclusion","Patients with a Dental Aesthetic Index Score of 26-30",{"label":16,"type":10,"description":17,"interventionNames":10},"Severe malocclusion","Patients with a Dental Aesthetic Index Score of 31-35",{"label":19,"type":10,"description":20,"interventionNames":10},"Obstructive malocclusion","Patients with a Dental Aesthetic Index Score ≥ 36",[22],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"Oguz KOSE, Professor Dr.","CONTACT","+90 541 348 64 65","oguz.kose@erdogan.edu.tr",[28],{"facility":29,"status":10,"city":30,"state":31,"zip":32,"country":33,"countryCode":10,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Department of Periodontology of the Faculty of Dentistry of Recep Tayyip Erdogan University","Rize","Rize Province","53200","Turkey (Türkiye)",{"type":35,"coordinates":36},"Point",[37,38],40.52194,41.02083,{"lat":38,"lon":37},[41],{"name":42,"role":24,"phone":43,"phoneExt":10,"email":44},"RTEU Faculty of Dentistry, Department of Periodontology","+90 464 222 00 00","dis@erdogan.edu.tr",{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dilek KARADOĞAN","Assoc. Prof. Dr.","100602763","relationship-between-malocclusion-severity-and-periodontitis-risk-100602763",false,"NCT07127744","Relationship Between Malocclusion Severity and Periodontitis Risk","Determination of the Relationship Between Orthodontic Malocclusion Severity and Periodontitis Risk Using RANKL, OPG and Oxidative Stress Markers","Inclusion Criteria:\n\n* Patients between the ages of 12 and 18,\n* Patients with all permanent teeth,\n* Not having taken antibiotics, steroids, and\u002For nonsteroidal anti-inflammatory drugs in the last 3 weeks,\n* Not having an active infectious disease,\n* Not having chronic medication use that affects periodontal tissues (cyclosporine A, Phenytoin),\n* Not having taken antioxidant supplements in the last 6 months.\n\nExclusion Criteria:\n\n* Presence of any congenital craniofacial deformity (cleft lip and palate or any other craniofacial syndrome or deformity),\n* Patients who have previously started or completed orthodontic treatment,\n* Patients who have received periodontal treatment in the last 6 months,\n* Acute illness,\n* Systemic illness, mental illness, immunosuppressive medications, or immunodeficiency.","ALL","12 Years","18 Years",{"count":60,"type":61},70,"ESTIMATED","1 Day","OBSERVATIONAL","The goal of this observational study is to examine the potential relationship between the severity of orthodontic malocclusion and the risk of developing periodontitis in individuals by evaluating salivary and gingival crevicular levels of RANKL, osteoprotegerin (OPG), and oxidative stress biomarkers.\n\nThe main question it aims to answer is:\n\nDoes increasing severity of orthodontic malocclusion contribute to a higher risk of periodontitis through changes in RANKL\u002FOPG balance and oxidative stress levels?\n\nParticipants with different levels of tooth misalignment (malocclusion) will be examined to assess the condition of their teeth and gums. During this examination, information such as dental plaque, gum bleeding, and the depth of gum pockets will be recorded. In addition, fluid samples collected from the gums will be tested in the laboratory to measure certain biological substances and chemical markers related to the body's balance between harmful and protective effects. These measurements will be done using special laboratory tests.",[66],"Malocclusion",[68,69,70,71,72],"malocclusion","periodontitis","RANKL","Osteoprotegerin","oxidative stress","NOT_YET_RECRUITING","2025-08-16",{"date":76,"type":77},"2025-08-22","ACTUAL",{"date":79,"type":61},"2025-09-15",{"date":81,"type":61},"2026-01-19",{"name":5,"class":6},1]