[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627770":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":31,"responsibleParty":44,"collaborators":10,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":71,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"University Hospital, Angers","OTHER_GOV",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"ARDS (Acute respiratory distress syndrome)",null,"Patient with ARDS who are placed on mechanical ventilation",[13],"Other: Non-interventionnal study",[15],{"type":16,"name":17,"description":17,"armGroupLabels":18,"otherNames":10},"OTHER","Non-interventionnal study",[9],[20],{"name":21,"affiliation":22,"role":23},"Pierre ASFAR","University Hospital of Angers","STUDY_CHAIR",[25,30],{"name":21,"role":26,"phone":27,"phoneExt":28,"email":29},"CONTACT","241353637","+33","pierre.asfar@chu-angers.fr",{"name":21,"role":26,"phone":10,"phoneExt":10,"email":29},[32],{"facility":22,"status":10,"city":33,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Angers","France","FR",{"type":37,"coordinates":38},"Point",[39,40],-0.55202,47.47156,{"lat":40,"lon":39},[43],{"name":21,"role":26,"phone":27,"phoneExt":28,"email":29},{"type":45,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100627770","relationship-between-the-level-of-positive-end-expiratory-pressure-and-venous-congestion-during-acute-respiratory-distress-syndrome-100627770",false,"NCT07452952","Relationship Between the Level of Positive End-expiratory Pressure and Venous Congestion During Acute Respiratory Distress Syndrome.","SURVEX","Inclusion Criteria:\n\n* Patients hospitalized in the Medical Intensive Care and Hyperbaric Medicine Unit of Angers University Hospital, receiving mechanical ventilation in assist-control mode (A\u002FC ventilation), and presenting with ARDS as defined by the following criteria (1):\n* Hypoxemia with a PaO₂ (mmHg)\u002FFiO₂ (0.21 to 1.0) ratio \\\u003C300 mmHg with a positive end-expiratory pressure (PEEP) ≥5 cmH₂O;\n* Pulmonary edema not fully explained by cardiac failure or fluid overload;\n* Presence of bilateral pulmonary opacities on chest imaging not fully explained by pleural effusions, atelectasis, or pulmonary nodules.\n\nExclusion Criteria:\n\n* Minor patient (\\\u003C18 years old)\n* ECMO (Extracorporeal Membrane Oxygenation)\n* Hemodynamic instability (mean arterial pressure \\\u003C60 mmHg)\n* Respiratory instability (SpO₂ \\\u003C90% under FiO₂ \\>90%)\n* Severe organic tricuspid regurgitation\n* Congenital heart disease\n* Pneumothorax\n* Renal or hepatic transplant recipient\n* Liver cirrhosis Child-Pugh C\n* Portal vein thrombosis or Budd-Chiari syndrom\n* Abdominal compartment syndrome documented by intra-abdominal pressure ≥20 mmHg\n* Pregnant, breastfeeding, or peripartum women\n* Persons deprived of liberty by judicial or administrative decision\n* Persons subject to compulsory psychiatric care\n* Persons under legal protective measures","ALL","18 Years","99 Years",{"count":57,"type":58},30,"ESTIMATED","OBSERVATIONAL","The main objective is to assess the effect of increased PEEP on echo-Doppler venous congestion in ARDS patients at two PEEP levels, by grading congestion in each venous flow (suprahepatic, renal, portal) as \"absent,\" \"moderate,\" or \"severe,\" and also calculating the VExUS score.",[62,63],"Mechanical Ventilation","Acute Respiratory Distress Syndrome (ARDS)",[65,66,67,68,69,70],"ARDS","venous congestion","VEXUS","PEP","right heart failure","acute cor pulmonale","NOT_YET_RECRUITING","2026-02-27",{"date":74,"type":75},"2026-03-05","ACTUAL",{"date":77,"type":58},"2026-03-01",{"date":79,"type":58},"2027-11-01",{"name":5,"class":6},1]