[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642008":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":51,"collaborators":26,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":26,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":26,"enrollmentInfo":62,"targetDuration":26,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":75,"whyStopped":26,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Fatih Sultan Mehmet Training and Research Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"remifentanil group","EXPERIMENTAL","Participants will receive remifentanil 0.5-1 µg\u002Fkg intravenously over 90 seconds before endotracheal intubation during induction of general anesthesia for elective cerebral aneurysm coil embolization.",[13],"Drug: Remifentanil",{"label":15,"type":16,"description":17,"interventionNames":18},"Esmolol Group","ACTIVE_COMPARATOR","Participants will receive esmolol 0.5-1 mg\u002Fkg intravenously over 90 seconds before endotracheal intubation during induction of general anesthesia for elective cerebral aneurysm coil embolization.",[19],"Drug: Esmolol",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Remifentanil","Remifentanil 0.5-1 µg\u002Fkg IV administered over 90 seconds before endotracheal intubation.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Esmolol","Esmolol 0.5-1 mg\u002Fkg IV administered over 90 seconds before endotracheal intubation.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Arsen Güngör Ay, MD","CONTACT","+905534948426","arsen.gungor@hotmail.com",[38],{"facility":5,"status":26,"city":39,"state":39,"zip":40,"country":41,"countryCode":26,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Istanbul","34752","Turkey (Türkiye)",{"type":43,"coordinates":44},"Point",[45,46],28.94966,41.01384,{"lat":46,"lon":45},[49],{"name":33,"role":34,"phone":50,"phoneExt":26,"email":36},"0905534948426",{"type":52,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100642008","remifentanil-vs-esmolol-during-intubation-for-cerebral-aneurysm-coil-embolization-100642008",false,"NCT07660861","Remifentanil vs Esmolol During Intubation for Cerebral Aneurysm Coil Embolization","Effects of Remifentanil Versus Esmolol on Optic Nerve Sheath Diameter\u002FEyeball Transverse Diameter Ratio During Endotracheal Intubation in Patients Undergoing Cerebral Aneurysm Coil Embolization: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥18 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective cerebral aneurysm coil embolization under general anesthesia\n* Planned endotracheal intubation\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Emergency procedures\n* Hemodynamic instability before induction of anesthesia\n* Severe cardiac conduction abnormalities or clinically significant arrhythmias\n* Contraindication or allergy to remifentanil or esmolol\n* Chronic opioid use or opioid dependence\n* Known orbital disease, ocular trauma, or conditions interfering with optic nerve sheath diameter measurements\n* Anticipated difficult airway\n* Pregnancy\n* Refusal to participate in the study","ALL","18 Years",{"count":63,"type":64},84,"ESTIMATED","INTERVENTIONAL",[67],"NA","Endotracheal intubation may cause significant increases in blood pressure, heart rate, and intracranial pressure, particularly in patients undergoing cerebral aneurysm coil embolization. Remifentanil and esmolol are commonly used agents to attenuate these responses during anesthesia induction.\n\nThis randomized controlled trial aims to compare the effects of remifentanil and esmolol administered before endotracheal intubation on optic nerve sheath diameter\u002Feyeball transverse diameter ratio (ONSD\u002FETD), a noninvasive surrogate marker of intracranial pressure, as well as hemodynamic responses in patients undergoing elective cerebral aneurysm coil embolization.\n\nThe findings may help identify the most effective strategy for minimizing intubation-related intracranial pressure changes and hemodynamic fluctuations in neurointerventional anesthesia practice.",[70,71],"Cerebral Aneurysm Unruptured","Intracranial Pressure",[73,71,23,28,74],"Optic Nerve Sheath Diameter","Coil Embolization","NOT_YET_RECRUITING","2026-06-16",{"date":78,"type":79},"2026-06-22","ACTUAL",{"date":78,"type":64},{"date":82,"type":64},"2027-07-01",{"name":5,"class":6},1]