[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100585670":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":32,"locations":42,"responsibleParty":64,"collaborators":24,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":24,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":24,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":90,"whyStopped":24,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Moringa Oleifera based varnish","EXPERIMENTAL","Moring Oleifera Varnish application Using a disposable bond brush, the varnish will be painted on the diagnosed surfaces, then the patient will be instructed to avoid brushing or flossing and to avoid hard and sticky food or any products that may contain alcohol (oral rinses, beverages, etc.) for the next 4 hours after application.",[13],"Other: Moringa Oleifera",{"label":15,"type":16,"description":17,"interventionNames":18},"MI varnish","ACTIVE_COMPARATOR","MI Varnish application\n\nThe varnish will be applied on the clean surfaces according to manufacturer instructions as follows:\n\n1. The foil cover of the MI Varnish unit dosage bottle will be peeled-off and MI Varnish will be stirred with the disposable brush before application.\n2. The surfaces will be covered with a thin uniform layer using a disposable bond brush to avoid clumping.\n3. The area will be allowed to become wet to ensure the setting of the varnish.",[19],"Other: Varnish",[21,25],{"type":6,"name":22,"description":11,"armGroupLabels":23,"otherNames":24},"Moringa Oleifera",[9],null,{"type":6,"name":26,"description":17,"armGroupLabels":27,"otherNames":24},"Varnish",[15],[29],{"name":30,"affiliation":5,"role":31},"Ahmed Zohair El-Hoshy, professor at Cairo University","PRINCIPAL_INVESTIGATOR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":24,"email":37},"Hend Taha Mahmoud, Phd candidate","CONTACT","+201028137519","hend.taha@dentistry.cu.edu.eg",{"name":39,"role":35,"phone":40,"phoneExt":24,"email":41},"Dina Mohamed Kamal, Lecturer at cairo university","01122551800","dina.kamal@dentistry.cu.edu.eg",[43],{"facility":44,"status":24,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Hend Taha Hanafi Mahmoud","Cairo","Cairo Governorate","02022","Egypt","EG",{"type":51,"coordinates":52},"Point",[53,54],31.24967,30.06263,{"lat":54,"lon":53},[57,60,63],{"name":58,"role":35,"phone":59,"phoneExt":24,"email":37},"Hend Taha Mahmoud, pdh cadidate","02201028137519",{"name":61,"role":35,"phone":62,"phoneExt":24,"email":41},"Dina Mohamed Kamal, lecturer at cairo university","0202201122551800",{"name":39,"role":35,"phone":24,"phoneExt":24,"email":24},{"type":31,"investigatorFullName":44,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Phd candidate","100585670","remineralization-efficacy-of-moringa-oleifera-varnish-vs-mi-varnish-in-initial-carious-lesions-over-6-months-follow-up-a-randomized-controlled-clinical-trial-100585670",false,"NCT06905379","Remineralization Efficacy of Moringa Oleifera Varnish Vs MI Varnish in Initial Carious Lesions Over 6 Months Follow Up: a Randomized Controlled Clinical Trial","Inclusion Criteria of participants:\n\n* Presentation with at least one active WSLs on the study teeth at the start of the study.\n* Good oral hygiene.\n* Co-operative patients approving to participate in the trial.\n* Have sufficient cognitive ability to understand consent procedures Inclusion criteria of teeth.\n* Active non-cavitated initial carious lesions (ICDAS 1\\&2)\n* DIAGNOdent score between (8-15)\n* Vital teeth with no signs or symptoms of irreversible pulpitis.\n* No signs of clinical mobility.\n* Teeth with healthy periodontium.\n\nExclusion Criteria of participants:\n\n* Participants with parafunctional habits or bruxism.\n* Participants with dry mouth.\n* Participants with systemic diseases or disabilities that may affect participation.\n* Heavy smoking.\n* Pregnancy.\n* Lack of compliance.\n* Severe or active periodontal disease.\n* Cognitive impairment\n\nExclusion criteria of teeth:\n\n* DIAGNOdent score less than 8 and more than 15\n* Untreated cavitated lesions or extensive restorations on the facial surfaces of the study teeth\n* Intrinsic or extremely heavy extrinsic staining\n* Periapical pathosis or signs of pulpal pathology.\n* Non-vital tooth.\n* Signs of pathological wear.\n* Endodontically treated tooth.\n* Severe periodontal affection or tooth indicated for extraction.",true,"ALL","25 Years","35 Years",{"count":77,"type":78},40,"ESTIMATED","INTERVENTIONAL",[81],"NA","This randomized clinical trial aimed to test the remineralization effect of laboratory prepared Moringa Oleifera based varnish compared to MI varnish (CPP-ACP) on incipient carious lesions. The study could include any of the following participants: age: 25-35 years, males or females, presentation with at least one active WSLs on the study teeth at the start of the study, good oral hygiene, co-operative patients approving to participate in the trial, have sufficient cognitive ability to understand consent procedures. The main question it aims to answer is in patients with initial caries lesions will Moringa Oleifera varnish have same remineralization efficacy as MI Varnish after 6 months follow up? MI varnish will be used as a comparator as it has been shown in many studies to be superior to fluoride varnish with NaF alone in arresting early caries lesions. The active ingredient, CPP-ACP can slowly release, localize and stabilize amorphous calcium, phosphate, and fluoride on the enamel surface which aids in deep mineralization of white spot lesions.",[84,22],"White Spot Lesions [Initial Caries] on Smooth Surface of Tooth",[22,15,86,87,88,89],"white spot lesions","remineralization","DIAGNOdent","Nyvad criteria","NOT_YET_RECRUITING","2025-03-25",{"date":93,"type":94},"2025-04-01","ACTUAL",{"date":96,"type":78},"2025-05-01",{"date":98,"type":78},"2026-01-01",{"name":5,"class":6},1]