[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591909":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":33,"locations":39,"responsibleParty":51,"collaborators":24,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":24,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":80,"whyStopped":24,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PRG Barrier coat","EXPERIMENTAL","Before the application of the varnish, teeth were cleaned using a prophylaxis polishing past with a low-speed cone brush in a contra-angle low-speed handpiece. It was then dried with air and isolated using cotton rolls According to the manufacturer's instructions, for the application of PRG barrier coat varnish, a drop of the active will be mixed with the base using the attached brush. After isolation with cotton rolls, the brush will be used to smear the WSLs with the mix. I will be undisturbed for at least three seconds, then cured for 10 seconds using the visible-light curing unit.\n\nAnd there will be no postoperative instruction to the patient after application (light-cured resin material).",[13],"Other: PRG Barrier coat",{"label":15,"type":16,"description":17,"interventionNames":18},"5% NaF fluoride varnish","ACTIVE_COMPARATOR","Before the application of the varnish, teeth were cleaned using a prophylaxis polishing past with a low-speed cone brush in a contra angle low-speed handpiece. It will be dried with air and isolated using cotton rolls.\n\nPackage will be unpacked, and the application guide will be used to display the contents and mix to avoid the separation of sodium fluoride components. After isolation, a thin layer of the varnish will coat . The participants will be asked to keep their mouths closed to allow the varnish to set in the presence of saliva. Rinsing or suction was not allowed immediately after the application of the varnish.\n\nThe participants will be asked to avoid consumption of rough and viscid food or hot drinks for two hours after application of the varnish. For the rest of that day, participants will be asked to eat soft food and stop tooth brushing (Ezzeldin et al., 2024",[19],"Other: 5% NaF fluoride varnish",[21,25],{"type":6,"name":15,"description":22,"armGroupLabels":23,"otherNames":24},"Before the application of the varnish, teeth were cleaned using a prophylaxis polishing past with a low-speed cone brush in a contra angle low-speed handpiece. It will be dried with air and isolated using cotton rolls.\n\nPackage will be unpacked, and the application guide will be used to display the contents and mix to avoid the separation of sodium fluoride components. After isolation, a thin layer of the varnish will coat . The participants will be asked to keep their mouths closed to allow the varnish to set in the presence of saliva. Rinsing or suction was not allowed immediately after the application of the varnish.\n\nThe participants will be asked to avoid consumption of rough and viscid food or hot drinks for two hours after application of the varnish. For the rest of that day, participants will be asked to eat soft food and stop tooth brushing (Ezzeldin et al., 2024).",[15],null,{"type":6,"name":9,"description":26,"armGroupLabels":27,"otherNames":24},"Before the application of the varnish, teeth were cleaned using a prophylaxis polishing past with a low-speed cone brush in a contra angle low-speed handpiece. It was then dried with air and isolated using cotton rolls.\n\n\\| P a g e 13 According to the manufacturer's instructions, the application of PRG barrier coat varnish a drop of the active will be mixed with the base using the attached brush. After isolation with cotton rolls, the brush will be used to smear the WSLs with the mix. I will be undisturbed for at least three seconds, then cured for 10 seconds using the visible-light curing unit (Ezzeldin etal.,2024).\n\nAnd there will be no post operative instruction to patient after application (light cured resin material).",[9],[29],{"name":30,"affiliation":31,"role":32},"Hala M. Abbas, PhD","Head of Department of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Cairo University","STUDY_DIRECTOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":24,"email":38},"Hanaa H.M.F.M. Rady, Master's student","CONTACT","+201006257884","Hanaa.hamdy@dentistry.cu.edu.eg",[40],{"facility":41,"status":24,"city":42,"state":24,"zip":24,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":24},"Faculty of Dentistry, Cairo University","Cairo","Egypt","EG",{"type":46,"coordinates":47},"Point",[48,49],31.24967,30.06263,{"lat":49,"lon":48},{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Hanaa Hamdy Mohamed Fathy Mahmoud Rady","dentist","100591909","remineralization-potential-of-prg-barrier-coat-versus-fluoride-varnish-in-white-spot-lesions-in-permanent-anterior-teeth-of-children-100591909",false,"NCT06986551","Remineralization Potential of PRG Barrier Coat Versus Fluoride Varnish in White Spot Lesions in Permanent Anterior Teeth of Children","Remineralization Potential of PRG Barrier Coat Versus Fluoride Varnish in White Spot Lesions in Permanent Anterior Teeth of Children (A Randomized Controlled Trial)","PRG Barrier","Inclusion Criteria:\n\n* Children aged 8-14 years with good health according to the American Society of Anesthesiologists (ASA-I).\n* Have at least one white spot lesion with International Caries Detection and Assessment System (ICDAS II) score one or two\n* Has not used any remineralizing agent in the former three months.\n* Parents who accept to sign informed consent.\n* Cooperative patients\n\nExclusion Criteria:\n\n* Patients have caries or restorations in the labial surface.\n* Extrinsic or intrinsic stains.\n* patients under active orthodontic treatment.\n* Uncooperative patient.\n* Parents refuse to sign informed consent.\n* Medically unfit (other than ASAI).","ALL","8 Years","14 Years",{"count":67,"type":68},78,"ESTIMATED","INTERVENTIONAL",[71],"NA","To evaluate the remineralization potential of PRG Barrier Coat versus fluoride varnish in white spot lesions in permanent anterior teeth of children.",[74,75],"White Spot Lesion of Tooth","Demineralization",[77,78,79],"PRG Barrier Coat","white spot lesion","Fluoride Varnish","NOT_YET_RECRUITING","2025-05-22",{"date":83,"type":84},"2025-05-28","ACTUAL",{"date":86,"type":68},"2025-09",{"date":88,"type":68},"2026-11",{"name":5,"class":6},1]