[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641451":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":23,"centralContacts":28,"locations":37,"responsibleParty":86,"collaborators":10,"id":88,"slug":89,"hasResults":90,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":10,"eligibilityCriteria":94,"healthyVolunteers":90,"sex":95,"minAge":96,"maxAge":97,"enrollmentInfo":98,"targetDuration":10,"studyType":101,"phases":10,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Medical University of Warsaw","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"40 patients with refractory chronic cough lasting more than 6 months.",null,"Patients were eligible for inclusion if they:\n\nwere 18-75 years old; had chronic cough lasting more than 12 months unresponsive to previous treatment presented with a normal or near normal chest radiograph or only abnormalities irrelevant to cough; and had clinical indications for bronchoscopy",[13],"Diagnostic Test: chest computed tomography and bronchoscopy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIAGNOSTIC_TEST","chest computed tomography and bronchoscopy","Assessment of airway remodeling features on chest CT in patients with chronic cough.\n\nEvaluation of airway injury and remodeling based on biological specimens obtained from the lower airways during bronchoscopy.Bronchoscopy is performed if clinically indicated.",[9],[21,22],"Assessment of airway remodeling features on chest computed tomography","Assessment of remodelling in bronchial biopsy or bronchoalveolar lavage fluid",[24],{"name":25,"affiliation":26,"role":27},"Rafał Krenke, MD, PhD, Prof","Department of Internal Medicine, Pulmonary Diseases and Allergy, Warsaw Medical University","STUDY_DIRECTOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Marta Dabrowska, MD, PhD","CONTACT","+48 501157765","mdabrowska@mp.pl",{"name":35,"role":31,"phone":36,"phoneExt":10,"email":33},"Karolina Klimowicz, MD","+48 507045417",[38,61,70,79],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw","RECRUITING","Warsaw","Masovian Voivodeship","02-097","Poland","PL",{"type":47,"coordinates":48},"Point",[49,50],21.01178,52.22977,{"lat":50,"lon":49},[53,55,57,59],{"name":54,"role":31,"phone":32,"phoneExt":10,"email":33},"Marta Dąbrowska, MD, PhD",{"name":35,"role":31,"phone":36,"phoneExt":10,"email":56},"karolinaakrakowiak@gmail.com",{"name":54,"role":58,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"name":35,"role":60,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"facility":39,"status":40,"city":41,"state":41,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":62,"geoPoint":64,"contacts":65},{"type":47,"coordinates":63},[49,50],{"lat":50,"lon":49},[66,68,69],{"name":67,"role":31,"phone":32,"phoneExt":10,"email":33},"Marta Dąbrowska",{"name":35,"role":31,"phone":36,"phoneExt":10,"email":33},{"name":54,"role":58,"phone":10,"phoneExt":10,"email":10},{"facility":5,"status":40,"city":41,"state":10,"zip":71,"country":44,"countryCode":45,"cosmosGeoPoint":72,"geoPoint":74,"contacts":75},"02-091",{"type":47,"coordinates":73},[49,50],{"lat":50,"lon":49},[76],{"name":77,"role":31,"phone":78,"phoneExt":10,"email":56},"Karolina Klimowicz, PhD candidate","+48507045417",{"facility":39,"status":40,"city":41,"state":10,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":80,"geoPoint":82,"contacts":83},{"type":47,"coordinates":81},[49,50],{"lat":50,"lon":49},[84],{"name":67,"role":31,"phone":85,"phoneExt":10,"email":33},"501157765",{"type":87,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100641451","remodelling-of-the-lower-airways-in-chronic-cough-100641451",false,"NCT07659860","Remodelling of the Lower Airways in Chronic Cough","Does Chronic Cough Lead to Injury and Remodelling of the Lower Airways?","Inclusion criteria for the study group:\n\n1. age between 18 and 75 years,\n2. chronic cough of at least one year duration, with no previous treatment (at least 2 previous unsuccessful attempts at pharmacological treatment of cough)\n3. negative history of smoking (at least 6 months of abstinence),\n4. negative history of treatment with angiotensin-converting enzyme inhibitors (ACEI),\n5. normal chest radiograph or with changes not relevant to cough formation,\n6. no respiratory tract infections in the past 6 weeks,\n7. written consent from the patient to participate in the study.\n\nExclusion Criteria:\n\n1. patients less than 18 and more than 75 years of age,\n2. cough lasting less than 12 months,\n3. active smoking or abstinence period of less than 6 months,\n4. respiratory tract infection 6 weeks prior to inclusion or at the time of study conduct - retry inclusion after 6 weeks,\n5. cancer or interstitial lung disease,\n6. contraindications to functional testing, sputum induction or bronchoscopy","ALL","18 Years","75 Years",{"count":99,"type":100},40,"ESTIMATED","OBSERVATIONAL","The aim of the study is to assess if chronic cough leads to injury and remodelling of the airways. We plan to analyse bronchial injury and remodelling in patients with refractory chronic cough lasting longer than 12 month . Assessment of injury mediators will be performed in blood and bronchoalveolar lavage fluid. Remodelling features will be analysed based on chest CT scan and pathologic specimens. Injury of epithelium will be assessed in bronchial biopsy specimens. The relationship between the duration, severity of chronic cough, and bronchial inflammation, damage, remodelling will be analysed.",[104],"Chronic Cough",[106,107],"remodelling","chronic cough","2026-06-15",{"date":110,"type":111},"2026-06-22","ACTUAL",{"date":113,"type":111},"2022-10-01",{"date":115,"type":100},"2026-08-30",{"name":5,"class":6},4]